Protein Alignment Myo28B1 and myh7

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001106204.1
• Gene: myh7 / 30616
• ZFINID: ZDB-GENE-991123-5
• Length: 1938
• Species: Danio rerio
• Alignment Length: 2018
• Identity: 526/2018 - (26%)
• Similarity: 864/2018 - (42%)
• Gaps: 420/2018 - (20%)

  Fly    16 KPQNTTSEFAVP------FGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVEDMIT 74
            :|.:...|..||      ..|.||..|..:..|..::.|...|...|: ...:....:.:|||..
Zfish    29 RPFDMKKECFVPDPDEEYVKASIVSREGDKVTVQTEKRKTVTVKEADI-HPQNPPKFDKIEDMAM 92

  Fly    75 LGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAI 139
            ...|.|..:|.||:.|||..:||||:|...|.:|||:.||:|....:..||.|..:|.|||||:|
Zfish    93 FTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVVAYRGKKRSEAPPHIFSI 157

  Fly   140 SDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISG----------KHSWIEQQIIEA 194
            ||||:|.:...:|||.::|:||||||||.:||.::||.|:|:.          |...:|.|||:|
Zfish   158 SDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAGGSAKKEGAEKKGTLEDQIIQA 222

  Fly   195 NPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYC 259
            ||.:||||||||:||||||||||:|.|.|...|.:..|.|:.|||||||:.||.:.||:|||||.
Zfish   223 NPALEAFGNAKTIRNDNSSRFGKFIRIHFGASGKLASADIETYLLEKSRVTFQLKAERDYHIFYQ 287

  Fly   260 MLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILS 324
            :|:.......|.| |...:|..|.|::||.. |:....|.::......|..||.|..||...|..
Zfish   288 ILSQRKPELLEML-LITNNPYDYAYISQGET-TVASINDGEELLATDEAFDVLGFTQEEKNGIYK 350

  Fly   325 LLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTS 389
            |:.||:|.||::|...:  ....||.|.|.:..:||.|:|:..:.|...|....:.|..|.||..
Zfish   351 LIGAIMHFGNMKFKQKQ--REEQAEADGTEDGDKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKG 413

  Fly   390 LSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMN-SIGVLDIFGFENFDNNSFEQLC 453
            .:.:.......|..||:|:.:|:.:|.|||::::.:  ||.. .||||||.|||.||.|:|||||
Zfish   414 QNVQQVYYAIGALAKSVYEKMFLWMVVRINQSLDTK--QPRQYFIGVLDIAGFEIFDFNTFEQLC 476

  Fly   454 INYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMKPMNLMSLIDEESKFP 517
            ||:.||.|||||..|:|.:||:||:.|.|.|:.|:| .|.|..:||| .|||.:||:::||..||
Zfish   477 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLI-EKPMGIMSILEEECMFP 540

  Fly   518 KGTDQTLLEKLHVQHGNRS------IYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGD 576
            |.:|.|...||:..|..:|      ..:|||  ..|.|.:.||||.|.||...:|.||:|..:..
Zfish   541 KASDSTFKAKLYDNHLGKSNNFQKPRAIKGK--PESHFSLVHYAGTVDYNINNWLVKNKDPLNET 603

  Fly   577 LRTLVQRSTNKYLVDIFPHEMPMDT----------AKKQ----PTLCVKFRNSLDMLMRTLSQAH 627
            :..|.|:||.|.|..:|.:....::          :||:    .|:....|.:|:.||..|...|
Zfish   604 VVGLFQKSTVKLLSMLFANYAGTESDNGKGGKGGGSKKKGSSFQTVSALHRENLNKLMTNLRSTH 668

  Fly   628 PYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP 692
            |:|:|||.|||.|.|...:..|.:.|||.:|::|..||.|.|:|.|..|..|.:|||:|.|...|
Zfish   669 PHFVRCIIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPAAIP 733

  Fly   693 LEQ-CDCRKLARQICEVALPADSDR-QYGKTKLFLRDEDDASLELQRS---QLMLKSIVTIQRG- 751
            ..| .|.||.|.::.. :|..|.:: ::|.||:|.:......||..|.   .|::..|....||
Zfish   734 EGQFIDSRKGAEKLLG-SLDIDHNQYKFGHTKVFFKAGLLGQLEEMRDDRLSLIISGIQARSRGL 797

  Fly   752 IRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIK 816
            :.||.|::.::| |:|::.:|...|..:..:.:..|:. |.::...:.:.:...:...::....|
Zfish   798 LARVEFQKIVER-RDALLVIQWNVRAFMGVKNWPWMKL-FFKIKPLLKSAEAEKEMANMKDEFAK 860

  Fly   817 L-QALSRGYLVRKDFQKKLLE-RRKQNQLKKEELLKLAKMKEAEELLRLQQL---KEQKEREQRE 876
            | :|.::....||:.::|::. .:::|.|:.:...:...:.:|||  |..||   |.|.|.:.:|
Zfish   861 LKEAYAKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLCDAEE--RCDQLIKNKIQLEAKAKE 923

  Fly   877 QQEKRLQEEQRLKAEAAARN-----------------ALAMAAVQQKRRT--KPVKQEAPKAPTL 922
            ..| ||::|:.:.||..|:.                 .|.:|.|::::..  ..||....:...|
Zfish   924 LTE-RLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAL 987

  Fly   923 QARNSLPPPPTTLIVAAPLPTRPA-------------SAVTRINTIPESPGTIDVESSKQMVDDV 974
            ..           |:|.....:.|             |...::||:.::...::     |.|||:
Zfish   988 DD-----------IIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLE-----QQVDDL 1036

  Fly   975 FRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKS 1039
            ...|..|     :||..    |..|..:.:..::..:..|.:           ..:::::.|::.
Zfish  1037 EGSLEQE-----KKLRM----DLERAKRKLEGDLKLTQESLM-----------DLENDKQQLEER 1081

  Fly  1040 LLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVR 1104
            |.|.:..|.::..|               :....|:.:    .|...|..|....:..:..|...
Zfish  1082 LKKKDFEISQLNGK---------------IEDEQTICI----QLQKKLKELQARIEELEEELEAE 1127

  Fly  1105 QSQR-RIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNP 1168
            ::.| ::.|..|...:|.:|.        :..||                 |.......|:.:|.
Zfish  1128 RAARAKVEKQRADLARELEEI--------SERLE-----------------EAGGATAAQIEMNK 1167

  Fly  1169 SRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLF 1233
            .|.:                   ||: .||..:::.|.|.:||.:..|         :.|..|:.
Zfish  1168 KREA-------------------EFQ-KLRRDLEEATLQHEATAATLR---------KKQADSVA 1203

  Fly  1234 EL------------HAIRGRHPLRLDI--------HL------MDGQQRRL--QVDAASTAREAV 1270
            ||            ...:.:..|||::        |:      ::...|.|  |::...|..|.
Zfish  1204 ELGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEHVVKTKANLEKMTRSLEDQMNEYKTKYEE- 1267

  Fly  1271 NQLCQGMGLTD-TFGFGLVMSLNGKLMPLGAGQEHVLDAISECE----------QRQLDAPWKL- 1323
            .|.|    :.| |.....:.|.||:|......::.::..::..:          :|||:...|.
Zfish  1268 GQRC----INDFTMQKSKLQSENGELSRQLEEKDSLVSQLTRSKMSYTQQIEDLKRQLEEETKAK 1328

  Fly  1324 ---------------YIRKEMFATWYDPSMDPKATQLIYKQILNGL-----KCGEYRCRSEKDIA 1368
                           .:|::     |:...:.||      ::..|:     :..::|.:.|.|
Zfish  1329 SALAHAVQSARHDTDLLREQ-----YEEEQEAKA------ELQRGMSKANSEVAQWRTKYETD-- 1380

  Fly  1369 MVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLL 1433
                          .|.|.:..|......:..|...|.|:|..:...::..:....::.|..||:
Zfish  1381 --------------AIQRTEELEEAKKKLAQRLQETEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431

  Fly  1434 LEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKE-GPKLQSDELMLGINSAGLFLIDETEQVLASC 1497
            ::.::.......|       .:..|.|:.|..| ..|.:..:..|           |:.|..|.|
Zfish  1432 VDLERSNAAAAAL-------DKKQRNFDKVLSEWKQKFEESQAEL-----------ESSQKEARC 1478

  Fly  1498 CFSEVLKVHVESDDKL-HVMTFQHVNFVLQCSSAQDANEVIN------YMLDNLR-----QRSSY 1550
            ..:|:.|:....::.| |:.|.:..|..|| ....|..|.:.      :.|:.:|     ::|..
Zfish  1479 LSTELFKLKNSYEEALDHLETMKRENKNLQ-EEISDLTEQLGEGGKSIHELEKMRKQLEQEKSEI 1542

  Fly  1551 GVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLAT 1615
            ..||:. .|..||           ..|..:..|||               ::.|..|...|.||
Zfish  1543 QSALEE-AEASLE-----------HEEGKILRAQL---------------EFSQIKADIERKLA- 1579

  Fly  1616 LTKPSEKLQDILREGRFQEPPKPTPRANY-SRRRQHNISQLAESHFREPLDSDKAPLSKFSPEPL 1679
                 ||.:::.:..|..:....|.:::. |..|..|.:...:......|:..:..||:.:.:..
Zfish  1580 -----EKDEEMEQSKRNLQRTIDTLQSSLESETRSRNEALRIKKKMEGDLNEMEIQLSQANRQAA 1639

  Fly  1680 KAPLLKAVVKVPPLFQQALVMHHHILK---YMGDIARSN--LPVNTDLIFQPALQHPLLCDELYC 1739
            :|.            :|...:|.|:..   .:.|..|:|  |..||.::.:   ::.||..||
Zfish  1640 EAQ------------KQLKSVHAHMKDAQLQLDDSLRTNEDLKENTAIVER---RNNLLQAEL-- 1687

  Fly  1740 QLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALADACLKRLKRSLAQG 1804
               ::|  ..:.|..:||       ..|....:|...|.:.||..:..:|.:. .|:|:..::|.
Zfish  1688 ---EEL--RAALEQTERG-------RKLAEQELLDTSERVQLLHSQNTSLLNQ-KKKLETDISQL 1739

  Fly  1805 QRKKAPHLIEVEGIQQRCLHIYHKI--YFPDDTVEAFEI--ESHTRG---------AELIADIAQ 1856
            |       .|||...|.|.:...|.  ...|..:.|.|:  |..|..         .:.|.|:..
Zfish  1740 Q-------TEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH 1797

  Fly  1857 RLE 1859
            ||:
Zfish  1798 RLD 1800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	280/678 (41%)
		IQ	765..785	CDD:197470	4/19 (21%)
		Atrophin-1	<820..>946	CDD:460830	30/148 (20%)
		MyTH4	1031..1239	CDD:470587	34/220 (15%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	22/133 (17%)
		B41	1248..1429	CDD:214604	33/228 (14%)
		PH-like	1454..1547	CDD:473070	22/105 (21%)
		MyTH4	1674..1819	CDD:214535	31/149 (21%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	10/48 (21%)
		B41	1827..2032	CDD:214604	10/46 (22%)
		FERM_C2_MyoVII	2028..2121	CDD:270020
myh7	NP_001106204.1	COG5022	36..1438	CDD:227355	434/1558 (28%)
		MYSc_class_II	99..768	CDD:276951	280/678 (41%)
		SMC_prok_B	1146..>1938	CDD:274008	150/830 (18%)