DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo28B1 and Myo9a

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:XP_006511271.1 Gene:Myo9a / 270163 MGIID:107735 Length:2633 Species:Mus musculus


Alignment Length:2550 Identity:616/2550 - (24%)
Similarity:965/2550 - (37%) Gaps:846/2550 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            |:|.:|:.:|.||.|.|:|.||:||:..:.||||.||:|:||||::.||||..:.:::|.|..|.
Mouse   145 QKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLG 209

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQIIE 193
            :|.|||:|::|.|:..:.:.|:|||:|||||||:|||:||..::.:|.|:|  |..|.:||.|:.
Mouse   210 KLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILG 274

  Fly   194 ANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFY 258
            |.|::||||||||..|:|||||||:|::.:...|.:.||.:::|||||||:|:|..:|||||:||
Mouse   275 AGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFY 339

  Fly   259 CMLAGLSTAERERLKLQEQSPSQYHYLAQ-------------------GGCFTLPGRGDAKDFAD 304
            .:|||.|  |.|||....:.|.:||:|.|                   ..|||:.|.....||..
Mouse   340 YLLAGAS--EEERLAFHLKQPEEYHFLNQITKKPLRQSWDDYCYDSEPQDCFTVEGEDLRHDFER 402

  Fly   305 IRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFT----ATEVANLATAEIDDTPNLQRVAQLLGI 365
            ::.||:::.|.|:....|.|||:|||||||:.:.    ..:..::...|:     |..|::||.:
Mouse   403 LQLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYRDDSIDICNPEV-----LPIVSELLEV 462

  Fly   366 PISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETI--NKQVDQ 428
            ....|..||..|.....||.:........|:..|::..||||..:|..||.|||..:  :|.::|
Mouse   463 KEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEQ 527

  Fly   429 PMN--SIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQD 491
            ...  |||||||||||:::||||||.|||:|||.||.:|..||||:||:||:.|.|:|.:|::.|
Mouse   528 DTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYID 592

  Fly   492 NQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAG 556
            |...::||..||..|:.|:||||.||:.|:||||:|...||...| |::........|.|:||||
Mouse   593 NTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENS-YIEFPAVMEPAFIIKHYAG 656

  Fly   557 VVMYNPLGFLEKNRDSFSGDLRTLVQRSTN----------------------------------- 586
            .|.|....|.|||.|....|:..|::.|.|                                   
Mouse   657 KVKYGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAVVAFREAGK 721

  Fly   587 ---------------------------------------------KY------------------ 588
                                                         ||                  
Mouse   722 RHIQRKSGHDDTTPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMN 786

  Fly   589 --------------------------------LVD---IFPHE---------------------- 596
                                            |:|   ||.|.                      
Mouse   787 TLNEKNQHDTFDIAWNVRTGIRQSRLPASNTSLLDKDGIFAHSASSKLLERAHGILTRNKNFRSK 851

  Fly   597 -----------------------------MPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIR 632
                                         :.:...||.|::..:|:.||..||.||.||.|||::
Mouse   852 PVLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVK 916

  Fly   633 CIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCD 697
            ||:.|..|.|..|...|.:|||||:||:||.|||::||..:::::.||..:.:|:|......:.:
Mouse   917 CIRSNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPQHIIPSKFN 981

  Fly   698 CRKLARQICEVALPADSDR-QYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYM 761
            .:...|:|     ..:||. |.|||.:||::.:...|:....|.:|:.||.:||..|.:|.|:..
Mouse   982 IQDFFRKI-----NINSDNYQVGKTMVFLKEHERQHLQDLLHQEVLRRIVLLQRWFRVLLSRQQF 1041

  Fly   762 KRYREAIITVQRY--------------------------------WRGRLQRRKYQVMRQGFHRL 794
            ...|:|.|.:||:                                ||..|:|::|..:|      
Mouse  1042 LHLRQASIIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQASWRAHLERQRYLELR------ 1100

  Fly   795 GACIAAQQLTTKFTMVRCR---TIKLQALSRGYLVRKDFQKK-----LLE--------RRKQNQL 843
            .|.:..||...:  :.|||   ...:|:..|||..||.::::     ||:        |::.|.|
Mouse  1101 AAAVIIQQRWRE--LYRCRHKAATCIQSRWRGYRQRKKYKEQRNKIILLQSIYRGFRARQRCNAL 1163

  Fly   844 KKEELLKLAKMK-----------------------------------------EAEELLRLQQLK 867
             |||.|:.||::                                         |:..:.|...:.
Mouse  1164 -KEEKLREAKLEHGLVHVKACGPLEIQGSDPSEWEDRSFDNRVKAIEECKYVIESNRISRESSMD 1227

  Fly   868 EQKEREQREQQEKR------LQEE----QRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTL 922
            ..||...::|:..|      |||:    ||.|:...........|.::.||.:.::|.......|
Mouse  1228 FSKESPDKQQERGRRQSGTDLQEDVIVRQRPKSLEDLHQKKVGRAKRESRRMRELEQAIFSLELL 1292

  Fly   923 QARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPE---SP-GTIDVESSKQMVDDVFRFLN--DE 981
            :.|:          :....|:......|.:  :||   || ||.|.|||:..::.:....|  .:
Mouse  1293 KVRS----------LGGMSPSEERRWSTEL--MPEGLQSPHGTPDSESSQGSLELLTCDENQKSK 1345

  Fly   982 PDAALRKLN--NISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHE---RKPLKKSLL 1041
            |::.:....  .|||.:|...|||..|.:..|.    :.::|..|.||::..|   ....|:.|:
Mouse  1346 PESLILDEGELKISSPNTFTNPKSQDNALSASS----ETSSTLAGKGASSDSEHLKNGTAKEKLV 1406

  Fly  1042 KHEHPI-------DEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKP 1099
            ....||       |...|.:  |....::.....:.:|..|......|.:.:..::|.|:     
Mouse  1407 CSSEPITCKPQLRDSFVSSS--LPTFFYIPHQEALKTSSHLDTSIQRNKLPEREAILKTT----- 1464

  Fly  1100 RLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTS-----HLEKIHFIIGHGIIKNSLRD----- 1154
              ..:...|...|...||::...      ||..:|     .|||::       |:...|.     
Mouse  1465 --LTQDINREARKCQFSGDQMTP------LNTDSSCTVLKKLEKLN-------IEKEKRQKQLQQ 1514

  Fly  1155 ----EILAQICKQL-----------YLNPSRSSYSRGWLLLSLCLSCFPPSKEFEP----HLRSF 1200
                |::.||.:|.           .:..||:..|      .|..|.:.|.::.|.    ::::.
Mouse  1515 QNEKEMMEQIRQQTDILEKERKAFKTIEQSRTEAS------VLAPSFYQPRQKVERPCSLYIQNT 1573

  Fly  1201 MKQGTAQLQATPS-LQRLERTLVN--------GPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQR 1256
            ..:|.|.:..:|| :.:.:..|..        .|:.:|.:||                       
Mouse  1574 PSKGEAGVLGSPSAVTKRDAALATKDSPSIHLPPKDRPVTLF----------------------- 1615

  Fly  1257 RLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPL--GAGQEHVLDAISECEQRQLDA 1319
                      .|.....||              |...|.:|.  ..|.:|             ||
Mouse  1616 ----------FEKKGSPCQ--------------SRTVKELPKTERTGTQH-------------DA 1643

  Fly  1320 PWKL----YIRKEMFATWY-------DPSMDPKATQLIY---KQILNGLKCGEYRCRSEKDIAMV 1370
            .:||    ...::.|.:.:       |||.:..:..:.:   ..|...:..|..:...:.:.|..
Mouse  1644 AYKLSNNRSTERDHFKSTHFYSHRSDDPSREGSSRAIFFTPKDNITPLVHSGNPQAHKQDESAWK 1708

  Fly  1371 CALACFVEYGPGEILRL-----KPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQN 1430
            ..||     |||:..::     |.....|...||.|..|..|            |.....:|:..
Mouse  1709 PKLA-----GPGQQEQVARPAHKKKARMARTRSDFLTRGTFA------------EGEGDTEEDDY 1756

  Fly  1431 DLLLEAQKRAKEDICLFAHLSWPM------RHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDE 1489
            |.::|                 |:      .||.|       ||          ::|.|.....:
Mouse  1757 DDIIE-----------------PLLSLDQASHSEL-------GP----------VSSLGQASHSD 1787

  Fly  1490 TEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSY---- 1550
            :|  :.|..||.     |:...|||....|  ..:.:.:..|.|::     ||...||:..    
Mouse  1788 SE--MTSQRFSS-----VDEQAKLHKAMSQ--GEITKLAVRQKASD-----LDIRPQRAKMRFWA 1838

  Fly  1551 --------GVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLA 1607
                    ...:.|..:.::....   ||      ..||.|...:......:.            
Mouse  1839 KGKQGEKKTTRVKPASQSEISSFF---PG------PDVTPAHPFSDELTQYHP------------ 1882

  Fly  1608 GNVRVLATLTKP-SEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDS----- 1666
                     |.| |.:|....|: .|:|..:|:|:|  .|:|...||.:|       |||     
Mouse  1883 ---------TPPLSPELPGSCRK-EFKENKEPSPKA--KRKRGVKISSVA-------LDSMHWQN 1928

  Fly  1667 DKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNT--DLIFQPALQ 1729
            |...:.. |...||:                  |...:||.|.|:...:...:|  |::|:.||:
Mouse  1929 DSVQIIA-SASDLKS------------------MDEFLLKKMNDLDNEDSKKDTLVDVVFKKALK 1974

  Fly  1730 H-----------PLLCD--------ELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLV- 1774
            .           .|..|        :||. |.:|:.:. :...|:|.|:...:...:....|.: 
Mouse  1975 EFRQNIFSSYSSALAMDDGKSIRYKDLYA-LFEQILEK-TMRLEQRDWNESPVRVWVNTFKVFLD 2037

  Fly  1775 --MRELIILLRMRADALADACLK--RLKRSLAQGQRKKAPHLIEVEG------------------ 1817
              |.|...|     |:.|...||  |.||      |||...|:|...                  
Mouse  2038 EYMNEFKTL-----DSTAPKVLKTERKKR------RKKETDLVEEHNGHIFKATQYSIPTYCEYC 2091

  Fly  1818 -----IQQR------CLHIYH------------KIYFPDDTVEAFEIE-----SHTRGAELIAD- 1853
                 |..|      |.:..|            |.|.|:.:...|.:|     |..|...|:.: 
Mouse  2092 SSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRAVPLVVEK 2156

  Fly  1854 IAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQ--QRTIRSISDGQYQLHFMR 1916
            :...:|:.......|:.|:|.               |..|..|||  .....|::...|.:|.:.
Mouse  2157 LINYIEMHGLYTEGIYRKSGS---------------TNKIKELRQGLDTDAESVNLDDYNIHVIA 2206

  Fly  1917 ---KLWLNNHPGEDLNGDMIFSY-----PQELHKYLKGYYPIDCEQASRLAILVYSADHDVSLQR 1973
               |.||.:.|...:..::...:     .||..:.::|.|.: .:|.||        .|..:|:|
Mouse  2207 SVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSV-IDQLSR--------THLNTLER 2262

  Fly  1974 LPEVLTRL------------------------IPEDLIPLQTVAEWRQQILPKVHRDHLTEDHAK 2014
            |...|.|:                        .|:...|||:|                 :|.:|
Mouse  2263 LIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSV-----------------QDISK 2310

  Fly  2015 ILFLQELSHFACFGSTFFVVKQQN------DDALPETLLIAIN--STGFHMLDPTTKEILRSYEY 2071
            .....||          .||:|.|      .|.  .:|..|.|  .|...::..:.|.:|.:..:
Mouse  2311 TTTCVEL----------IVVEQMNKYKARLKDI--SSLEFAENKAKTRLSLIRRSMKPVLIAVRF 2363

  Fly  2072 SQLGIWS-SGKNHFH 2085
            ..:...| |||...|
Mouse  2364 MSITRSSVSGKGRIH 2378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 296/884 (33%)
MYSc_Myo7 81..726 CDD:276832 287/858 (33%)
IQ 765..785 CDD:197470 9/51 (18%)
DUF4355 827..>887 CDD:290964 22/123 (18%)
MyTH4 1031..1239 CDD:295320 45/255 (18%)
B41 1248..1429 CDD:214604 33/201 (16%)
FERM_N 1248..>1288 CDD:286467 3/39 (8%)
FERM_B-lobe 1342..1429 CDD:271216 17/94 (18%)
PH-like 1454..1547 CDD:302622 20/98 (20%)
MyTH4 1674..1819 CDD:214535 38/193 (20%)
B41 1827..2032 CDD:214604 47/256 (18%)
FERM_N 1829..>1877 CDD:286467 11/53 (21%)
FERM_M 1936..2032 CDD:278785 22/124 (18%)
FERM_C2_MyoVII 2028..2121 CDD:270020 15/66 (23%)
Myo9aXP_006511271.1 RA_Myosin-IXa 15..110 CDD:340736
MYSc_Myo9 160..1006 CDD:276836 287/858 (33%)
DUF5401 <968..>1283 CDD:375164 71/328 (22%)
IQ 1117..1138 CDD:197470 7/20 (35%)
PEHE <1827..1891 CDD:373705 11/93 (12%)
C1 2075..2123 CDD:237996 4/47 (9%)
RhoGAP_myosin_IX 2136..2321 CDD:239842 44/235 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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