Protein Alignment Myo28B1 and Myo7a

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_006229804.1
• Gene: Myo7a / 266714
• RGDID: 628830
• Length: 2276
• Species: Rattus norvegicus
• Alignment Length: 2283
• Identity: 934/2283 - (40%)
• Similarity: 1323/2283 - (57%)
• Gaps: 260/2283 - (11%)

  Fly     6 SPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV--LKAMHITSQED 68
            |..||:|||: ...:..||.||.||.:...|..|..|.||...:.|:...:.  :|.||.||...
  Rat    64 SSYKGDYVWM-DLKSGQEFDVPIGAMVKLCESGQIQVVDDEGNEHWISPQNATHIKPMHPTSVHG 127

  Fly    69 VEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELP 133
            |||||.||||.|..|||||..||...||||||||:|||:||||:|.||::..|:.|.||.:.|:|
  Rat   128 VEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSSEHIRQYTNKKIGEMP 192

  Fly   134 PHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIM 198
            ||||||:||.:..::|...:||.:||||||||||||||||||:||||||:|||||||::||.||:
  Rat   193 PHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPIL 257

  Fly   199 EAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAG 263
            ||||||||:||||||||||||:|.|..:|||:||:|:||||||||:..|:.||||||:|||||.|
  Rat   258 EAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFYCMLEG 322

  Fly   264 LSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAA 328
            ::..|:::|.|.:  .:.|:|||.|.|.|..||.|::::|:||:|||||.|...|.|.||.||||
  Rat   323 MNEEEKKKLGLGQ--AADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEILKLLAA 385

  Fly   329 ILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKE 393
            |||:|||::.|....||...|:..:|:|...|..|.:....|.:.||.||:...||.|:|.||:|
  Rat   386 ILHMGNLQYEARTFENLDACEVLFSPSLATAASHLEVNPPDLMSCLTSRTLITRGETVSTPLSRE 450

  Fly   394 AAIEGRDAFVKSLYDGIFVRIVRRINETINK----QVDQPMNSIGVLDIFGFENFDNNSFEQLCI 454
            .|::.||||||.:|..:||.||.:||..|.|    :|.....|||:|||||||||..||||||||
  Rat   451 QALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRSIGLLDIFGFENFTVNSFEQLCI 515

  Fly   455 NYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKG 519
            |:|||:||||||.|:||:||:||..|.|:|.||||.|||:.||:|..:|||::||||||||||||
  Rat   516 NFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKG 580

  Fly   520 TDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRS 584
            ||.|:|.||:.||...:.||..|.:..:.|||.|:||:|.|...||||||||:..||:..||..|
  Rat   581 TDATMLHKLNSQHRLNANYVPPKNSHETQFGINHFAGIVYYESQGFLEKNRDTLHGDIIQLVHSS 645

  Fly   585 TNKYLVDIFPHEMPM--DTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDK 647
            .||::..||..::.|  :|.|:.|||..:|:.||::|||||....|:|:|||||||:|:|..||:
  Rat   646 RNKFVKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDR 710

  Fly   648 ELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP-LEQCDCRKLARQICEVALP 711
            .||||||||||||||.|||.||||||:::..||||||:|:|.|.| .:|.|.:...:::.|..|.
  Rat   711 HLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQDDLQGTCQRMAEAVLG 775

  Fly   712 ADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWR 776
            ...|.|.||||:||:|..|..||::|.:.:...::.:|:.||....|....|.:.|...:||:||
  Rat   776 THDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWR 840

  Fly   777 GRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKL------- 834
            |...|:.|:::|.||.||.|...:::|..::.:.|.|.||.||..|.||||:.|:.:|
  Rat   841 GHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIKFQARCRAYLVRRAFRHRLWAVITVQ 905

  Fly   835 ------LERRKQNQLKKE-------ELLKLAKMKEAEELLRLQQLKEQKEREQREQQEK-----R 881
                  :.||...:|:.|       |.::||   |.|:|.:....|:.||..:|:.||:     |
  Rat   906 AYARGMIARRLHRRLRVEYWRRLEAERMRLA---EEEKLRKEMSAKKAKEEAERKHQERLAQLAR 967

  Fly   882 LQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPA 946
            ...|:.||.:..||....:....::.|.:|:...          :.:......|..::.||.:..
  Rat   968 EDAERELKEKEEARRKKELLQQMERARHEPINHS----------DMVDKMFGFLGTSSGLPGQEG 1022

  Fly   947 SAVTRINTIPESPGTIDVE-SSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDT 1010
            .|.:         |..|:| ..::||:       ::.|||              ||....:..|.
  Rat  1023 QAPS---------GFEDLERGRREMVE-------EDVDAA--------------LPLPDEDEEDL 1057

  Fly  1011 SDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTL 1075
            |::.:.|:|||||.|..|..:.|:|||:.||.|:...|::|:.|:|:||||||||||:    |..
  Rat  1058 SEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPE----PKY 1118

  Fly  1076 H--VFDNENLMSDLASLLNT--SDSYKPRLFVRQSQ----------------------------- 1107
            |  :.|....:..:..:..|  ..:||..|...|.:
  Rat  1119 HTAMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEAQLSEGQKKTSVKHKLVHLTLKKKSKL 1183

  Fly  1108 -RRIPKPLASGEKEAQ-----EFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYL 1166
             ..:.|.|..||...|     |      :.|||:|||:|||||:||::.:|||||..||.|||..
  Rat  1184 TEEVTKRLHDGESMVQGNSMLE------DRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTH 1242

  Fly  1167 NPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPS 1231
            |||:|||:|||:|:|||:.||.||::|..:||:|:..|... .|....:||.||.|||.|.||||
  Rat  1243 NPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPG-YAPYCEERLRRTFVNGTRTQPPS 1306

  Fly  1232 LFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLM 1296
            ..||.|.:.:.|:.|.:..|||..:.|..|:|:||:|..|.|...:.|.|.|||.|.::|..|:.
  Rat  1307 WLELQATKSKKPIMLPVTFMDGTTKTLLADSATTAKELCNALADKISLKDRFGFSLYIALFDKVS 1371

  Fly  1297 PLGAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGL 1354
            .||:|.:||:||||:|||       ::.:|||:|:.|||:|..|::||.|..||.|||:|::.|:
  Rat  1372 SLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHNPSEDNVATNLIYQQVVRGV 1436

  Fly  1355 KCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATY 1419
            |.|||||..|.|:|.:.:...||:||...||....|.:..::|...:.| .:.:|.|::|..|.:
  Rat  1437 KFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLSLVPTYIPDREITP-LKNLEKWAQLAIAAH 1500

  Fly  1420 EKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGL 1484
            :|..|.:..     .:||| .|:|:..:|...||:..||.:|..:..||.|...::::.:|..|:
  Rat  1501 KKGIYAQRR-----TDAQK-VKQDVVNYARFKWPLLFSRFYEAYKFSGPPLPKSDVIVAVNWTGV 1559

  Fly  1485 FLIDETEQVLASCCFSEVLKVHVESDDKL--------------H--------------------- 1514
            :.:||.||||....|.|::.|....:.::              |
  Rat  1560 YFVDEQEQVLLELSFPEIMAVSSSRECRVLLSLGCSDLGCASCHSGRAGLTPAGPCSPCWSCRGA 1624

  Fly  1515 --------VMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVAL--DPVVEGDLEDCLVLN 1569
                    :.|.:...:....|:|:|..:::...|:.||:||.|.|||  :|...|:....|...
  Rat  1625 KLMAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSFA 1689

  Fly  1570 PGDLIEFEAGVTGAQLMAGNAQDCYRGCVNG------QWGQFLAGNVRVLATLTKPSEKL----- 1623
            .||||..:.. ||.|:|..       |..||      |.|.|....|.|:.|:|.|..::
  Rat  1690 KGDLIILDHD-TGEQVMNS-------GWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVT 1746

  Fly  1624 ------QDILR--EGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAPLSK------- 1673
                  ||::|  :.|..||.        .|.:.:.:.:.:..:||.|   .|..||:
  Rat  1747 MTPDQRQDVVRLLQLRTAEPE--------VRTKPYTLEEFSYDYFRSP---PKHTLSRVMVSKAR 1800

  Fly  1674 -------FSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDI-ARSNLPVN--TDLIFQPAL 1728
                   .:.||||..|||.:|....|.|:|.:....:||||||. ::....||  ||.||:.|:
  Rat  1801 GKDRLWSHTREPLKQALLKKIVGSEELSQEACMSFIAVLKYMGDYPSKRTRSVNELTDQIFEWAV 1865

  Fly  1729 QHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADA-LADA 1792
            :...|.||.|.|::|||:||....||::||:||:|.|||..||.:::..:...|:.|... ||..
  Rat  1866 KAEPLKDEAYVQILKQLTDNHIRYSEEKGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAID 1930

  Fly  1793 CLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQR 1857
            ||:||:::|..|.||..|||:|||.||.:...|:||:||||||.||||:||.|:..:...:||.|
  Rat  1931 CLQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIASR 1995

  Fly  1858 LELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSISDG-----QYQLHFMRK 1917
            |.|||..|:|:|:|..|:|.::||.:|.|||:..|..|:::.|.|:   ||     .||:.||:|
  Rat  1996 LLLKSSEGFSLFVKIADKVISVPENDFFFDFVRHLTDWIKKARPIK---DGIVPSLTYQVFFMKK 2057

  Fly  1918 LWLNNHPGEDLNGDMIFSYPQELHKYLKGYYPIDCEQASRLAILVYSA--DHDVS-LQRLPEVLT 1979
            ||....||:|...|.||.|.|||.|||:||:....|:..:|..|:|..  :.|.| ...:|::|.
  Rat  2058 LWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLLR 2122

  Fly  1980 RLIPEDLIPLQTVAEWRQQILPKVHRDHL--TEDHAKILFLQELSHFACFGSTFFVVKQQNDDAL 2042
            .|:|:|||...:..:|::.|:...:: |.  :::.||:.||:.:..:..|||.||.|||..:...
  Rat  2123 ELVPQDLIRQVSPDDWKRSIVAYFNK-HAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTEPNF 2186

  Fly  2043 PETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIWSSGKNHFHIRFGNMIGASKLLCSTTQGYKM 2107
            ||.||||||..|..::||.||:||.::.::::..||||..:|||..||::..|||||.|:.||||
  Rat  2187 PEILLIAINKYGISLIDPRTKDILTTHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLGYKM 2251

  Fly  2108 DDLLASYV 2115
            ||||.||:
  Rat  2252 DDLLTSYI 2259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	371/651 (57%)
		IQ	765..785	CDD:197470	7/19 (37%)
		Atrophin-1	<820..>946	CDD:460830	34/150 (23%)
		MyTH4	1031..1239	CDD:470587	96/246 (39%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	41/97 (42%)
		B41	1248..1429	CDD:214604	74/187 (40%)
		PH-like	1454..1547	CDD:473070	25/135 (19%)
		MyTH4	1674..1819	CDD:214535	64/148 (43%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	46/98 (47%)
		B41	1827..2032	CDD:214604	85/214 (40%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	47/88 (53%)
Myo7a	XP_006229804.1	MYSc_Myo7	140..790	CDD:276832	371/651 (57%)
		DUF5401	<835..>991	CDD:375164	49/158 (31%)
		MAP7	<918..>996	CDD:461709	21/80 (26%)
		MyTH4	1078..1314	CDD:214535	96/246 (39%)
		FERM1_F1_Myosin-VII	1318..1416	CDD:340612	41/97 (42%)
		B41	1320..1535	CDD:214604	85/221 (38%)
		FERM_C1_MyoVII	1529..1665	CDD:270019	25/135 (19%)
		SH3_MYO7A	1666..1730	CDD:212814	23/71 (32%)
		MyTH4	1808..1957	CDD:214535	64/148 (43%)
		FERM2_F1_Myosin-VII	1962..2059	CDD:340613	46/99 (46%)
		B41	1964..2176	CDD:214604	85/215 (40%)
		FERM_C2_MyoVII	2172..2267	CDD:270020	47/88 (53%)