Protein Alignment Myo28B1 and Myo9b

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_063131141.1
• Gene: Myo9b / 25486
• RGDID: 3146
• Length: 2151
• Species: Rattus norvegicus
• Alignment Length: 2172
• Identity: 532/2172 - (24%)
• Similarity: 798/2172 - (36%)
• Gaps: 737/2172 - (33%)

  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            |.|.:|:..|.:|.|..:|::|:.|:.:|.||||.||:||||||::.||||..:.:::|.|:.|.
  Rat   145 QADFDDLCNLPELNEANLLQSLKLRFVQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLG 209

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQIIE 193
            :|.||:||::|.|:..:.|...|||:|||||||:|||:||..::..|.|:|  |..|.:|:.|:.
  Rat   210 KLEPHVFALADVAYYTMLRKHVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILG 274

  Fly   194 ANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFY 258
            |.|::||||||||..|:|||||||:|::.:...|.::||.:::|||||||:|.|.:||||||:||
  Rat   275 AGPVLEAFGNAKTAHNNNSSRFGKFIQVNYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFY 339

  Fly   259 CMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSIL 323
            .:|.|:|..||:..:|::  |..|.||.|.......|.....||..::.||:::.|.|.....|.
  Rat   340 YLLLGVSEEERQEFQLKQ--PQDYFYLNQHNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQIF 402

  Fly   324 SLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTT 388
            |:|:|||:|||:.:...........|:.....|..::|||.:....|...||:|......:.:..
  Rat   403 SVLSAILYLGNVTYKKRATGRDEGLEVGPPEVLDTLSQLLKVKRETLVEVLTKRKTITVNDKLIL 467

  Fly   389 SLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETI--NKQVDQPMN--SIGVLDIFGFENFDNNSF 449
            ..|...||..||:..||||..:|..||.|||..:  .|.:::.::  |||||||||||:|:.|||
  Rat   468 PYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSF 532

  Fly   450 EQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEES 514
            ||.|||||||.||.:|..||||:||:|||.|.|:|.:|::.||...:.||..||..|..|:||||
  Rat   533 EQFCINYANEQLQYYFTQHIFKLEQEEYQGEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEES 597

  Fly   515 KFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRT 579
            .||..|..|||.|...||.:.. |..|.......|.|:|:||.|.|....|.|||.|....|:..
  Rat   598 NFPHATSHTLLAKFKQQHEDNK-YFLGTPVLEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVA 661

  Fly   580 LVQRSTNKY---LVDIFP----------------------------------------------H 595
            |::.|.:.|   |:.:.|                                              .
  Rat   662 LLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAEAGVSSPVTRSHVE 726

  Fly   596 EMP-------------------------------------------------------------- 598
            |:|
  Rat   727 ELPRGANTPSEKLYRCAGLDFSFERSEELDVNAFEDIMAFYESRNDLHNQIIKSLKGLPWQGEDP 791

  Fly   599 ---------------------------------------------------------MDTAKKQP 606
                                                                     :...||.|
  Rat   792 RRLLQSLSRLQKPRTFFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKKKPP 856

  Fly   607 TLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYP 671
            ::..:|:.||:.|:..|.:|.|:|||||:.|..|:...||.||.::||||:||:||.||||:||.
  Rat   857 SISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYS 921

  Fly   672 IRHAYRAFVERYRLLVP-PVGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLEL 735
            .::.::.|.|::::|:| .|.|     ||:....:.|.......:.|.||||:||::.:..:|:.
  Rat   922 AKYTFQDFTEQFQVLLPKDVQP-----CREAIAALLEKLQVDRQNYQIGKTKVFLKETERQALQE 981

  Fly   736 QRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQ--------------- 785
            :....:|:.|:.:|...|.||.||:..:.:.|.:|:|..||....||..:
  Rat   982 RLHGEVLRRILLLQSWFRMVLERRHFVQMKHAALTIQACWRSYRVRRTLERTRAAVYLQAAWRGY 1046

  Fly   786 VMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLK------ 844
            :.||.:|.                .|...|:||:|.||:|.|:.|.:.:||::|..|.:
  Rat  1047 LQRQAYHH----------------QRHSIIRLQSLCRGHLQRRSFSQMMLEKQKAEQARETAGAE 1095

  Fly   845 --------------------------------------------KEEL------LKLAKMKEAEE 859
                                                        |:|:      ....|...||.
  Rat  1096 MSEGEPSPVAAGEQPSEHPVEDPESLGVETETWMNSKSPNGLSPKKEIPSPEMETPAQKTVPAES 1160

  Fly   860 LLRLQQLKEQKE-REQR-----EQQEKRLQ--EEQRLKAEAAARNALAMAAVQQKRRTKPVKQEA 916
            ..::...:|::| |.||     |:|.|.:|  .|:.......:|.|...........||..:::.
  Rat  1161 HEKVPSSREKRESRRQRGLEHVERQNKHIQSCREENSTLREPSRKASLETGESFPEDTKEPREDG 1225

  Fly   917 PKAPTLQARNSLP--------PP--PTTLIVAAPL-------PTRPASAV------------TRI 952
            .:..|..|..|.|        ||  |:.|...|.|       |..|:|::            |::
  Rat  1226 LETWTETAAPSCPKQVPIVGDPPRSPSPLQRPASLDLDSRVSPVLPSSSLESPQDEDKGENSTKV 1290

  Fly   953 NTIPESPG------------------TIDVESSKQMVDDVFR---FLNDEPDAALRKLN------ 990
            ...||||.                  .:::...|::...:..   .|:::|..|...|.
  Rat  1291 QDKPESPSGSTQIQRYQHPDTERLATAVEIWRGKKLASAMLSQSLDLSEKPRTAGAALTPTEERR 1355

  Fly   991 -NISSGDTIRLPKSVPNNIDTS-----DFSYLKYAA----------------------------- 1020
             :.|:.|..:|.   |..:.||     |.|..|.|.
  Rat  1356 ISFSTSDVSKLS---PVKVQTSTEVDGDLSAKKPAGHKKKSEDPSAGPDAGLPTGSQGDSKSAFK 1417

  Fly  1021 -------------------TYFGGGATAQHE-------------------RKPLK---------- 1037
                               |...||..||..                   .||||
  Rat  1418 RLFLHKAKDKKPSLEGVEETEGSGGQAAQEAPARKTLDVPSSQQHRHTTGEKPLKGKKNRNRKVG 1482

  Fly  1038 ---------------------------------KSLLKHEHPIDEMASKAIWLTILRFMGDLPDV 1069
                                             ..|...:.||:.:..:|    ..||..::..:
  Rat  1483 QITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEA----TERFRSNIKTM 1543

  Fly  1070 VSSPT--LHV-----FDN-ENLMSDLA----------------SLLNT-SDSYKPRLFVRQSQRR 1109
            .|.|.  :||     .:| :.::|:||                |||:. :.||....|....|.:
  Rat  1544 YSVPNGKIHVGYKDLMENYQIVVSNLAAERGEKDTNLVLNVFQSLLDEFTRSYNKTDFEPVKQGK 1608

  Fly  1110 IPKPLASGEKEAQE-----FYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDE-ILAQICKQL---- 1164
            ..|.....|:..||     |..:.:|:|.|..:.:.:|        .|.|: :|..:||..
  Rat  1609 AQKKKRKQERAVQEHNGHVFASYQVNIPQSCEQCLSYI--------WLMDKALLCSVCKMTCHKK 1665

  Fly  1165 ----------YLNPSRSSYSRGWLLLSLCLSCFPPSKEFEP--------HLRS--------FMKQ 1203
                      |....:|..........:|:......|...|        |:..        :.|.
  Rat  1666 CVHKIQSYCSYTGRRKSELGAEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKS 1730

  Fly  1204 GTAQ--------LQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQV 1260
            |.|.        ||..|:..:||.             |.:|||.|
  Rat  1731 GAANRTRELRQALQTDPATVKLED-------------FPIHAITG-------------------- 1762

  Fly  1261 DAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEH------VLDAISECEQRQLDA 1319
                ..::.:.:|.:.:.....:|..|      :.:.|...||.      |||.:.|.....|:
  Rat  1763 ----VLKQWLRELPEPLMTFAQYGDFL------RAVELPEKQEQLAAIYAVLDHLPEANHTSLE- 1816

  Fly  1320 PWKLYIRKEMFATWYDPS-MDPKATQLIYKQILNGLKCGEYR--CRSEKDIAMVCALACFVEYGP 1381
              :|.......|...|.: |.|.|..:|:...|  |:|.:..  ..|.||:.
  Rat  1817 --RLIFHLVKVALLEDVNRMSPGALAIIFAPCL--LRCPDNSDPLTSMKDVL------------- 1864

  Fly  1382 GEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICL 1446
                     :||..|               ..||.....|.....||.|.|      .|.|.|.
  Rat  1865 ---------KITTCV---------------EMLIKEQMRKYKVKMEEINHL------EAAESIA- 1898

  Fly  1447 FAHLS-------WPMR--HSRLFEVVRKEGPKL----QSDEL-MLGINSAGLFLIDETEQVLASC 1497
            |..||       ||::  .|..:|.||.:.|:.    ..:|| .|...:||   .||..:
  Rat  1899 FRRLSLLRQNAPWPLKLGFSSPYEGVRTKSPRTPVVQDLEELGALPEEAAG---GDEDRE----- 1955

  Fly  1498 CFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEGDL 1562
              .|:|...::                    |.::..:.|.|.|..|..|.|....||.......
  Rat  1956 --KEILMERIQ--------------------SIKEEKQDITYRLPELDPRGSDEENLDSETSAST 1998

  Fly  1563 EDCLVLNPGDLIEFEAGVTGA------------------QLMAGNAQDCYRGCVNGQWGQFLAGN 1609
            |        .|:| |..|.||                  .|.|..|..      .|:...|:  .
  Rat  1999 E--------SLLE-ERAVRGAAEGPPAPALPCPISPTPNPLPAATAPP------RGRPTSFV--T 2046

  Fly  1610 VRVLATLTKPSEKLQDI-LREG----------RFQEPPKPTPRANYSRRRQ---HNI-----SQL 1655
            |||......|...:.:| |..|          ..||...|..|.....|||   |::     :.|
  Rat  2047 VRVKTPRRTPIMPMANIKLPPGLPLHLTSWAPALQEAAVPVKRREPPARRQDQVHSVYIAPGADL 2111

  Fly  1656 AESHFREPLDSDKAPL----SKFSPEP 1678
            .......|||...|.|    .::|..|
  Rat  2112 PSQGTLGPLDHHDAILPGAKRRYSDPP 2138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	277/819 (34%)
		IQ	765..785	CDD:197470	7/19 (37%)
		Atrophin-1	<820..>946	CDD:460830	40/206 (19%)
		MyTH4	1031..1239	CDD:470587	56/338 (17%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	13/96 (14%)
		B41	1248..1429	CDD:214604	31/189 (16%)
		PH-like	1454..1547	CDD:473070	19/99 (19%)
		MyTH4	1674..1819	CDD:214535	2/5 (40%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myo9b	XP_063131141.1	None