DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and myo7aa

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	XP_021323248.1	Gene:	myo7aa / 252846	ZFINID:	ZDB-GENE-020709-1	Length:	2185	Species:	Danio rerio

Alignment Length:	2252	Identity:	932/2252 - (41%)
Similarity:	1314/2252 - (58%)	Gaps:	234/2252 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV--LKAMHITSQEDVE 70
            ::|:|||: ...|..||.||.||.:...:..|..|.||...:.|:...:.  :|.||.||...||
Zfish     5 QQGDYVWL-DLKTGHEFEVPIGAVVKLCDSGQIQVLDDEGNEHWISPQNATNIKPMHPTSIHGVE 68

  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIY------TYTGSMLVAINPYQILPIYTNREIQLYRNKSL 129
            |||.||||.|..|||||..||.:.|||      |||||:|||:||||:|||||..:|:||.||.:
Zfish    69 DMIRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTNKKI 133

  Fly   130 AELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEA 194
            .|:|||||||:||.:..:||..::||.:||||||||||||||||||:||||||:|||||||::||
Zfish   134 GEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEA 198

  Fly   195 NPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYC 259
            |||:||||||||:||||||||||||:|.|..:|||:||:|:||||||||:..|:|||||||||||
Zfish   199 NPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQARDERNYHIFYC 263

  Fly   260 MLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILS 324
            ||.|::..::::|.|.:  .:.|.||..|.|....||.|.|::::||:|||||.|..:|.|.|..
Zfish   264 MLKGMTPDQKKQLGLSK--ATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTDKENWEISK 326

  Fly   325 LLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTS 389
            |||||||:||||:.|....||...|:.....|...|.||.:.:..|...||.|||...||.|:|.
Zfish   327 LLAAILHMGNLRYEARTYDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLTSRTIITRGETVSTP 391

  Fly   390 LSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINK----QVDQPMNSIGVLDIFGFENFDNNSFE 450
            ||.|.|::.||||||.:|..:||.||.:||..|.|    ::.....|||:|||||||||..||||
Zfish   392 LSIEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRSIGLLDIFGFENFMVNSFE 456

  Fly   451 QLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESK 515
            |||||:||||||||||.|:||:||:||..|:||||||||.|||..||:|.:||||::||||||||
Zfish   457 QLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESK 521

  Fly   516 FPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTL 580
            ||||||.|:|.||:.||...:.|:..|.|..:.|||:|:||||.|...||||||||:..||:..|
Zfish   522 FPKGTDTTMLNKLNSQHKLNTNYIPPKNTYETQFGIQHFAGVVYYETRGFLEKNRDTLHGDIIQL 586

  Fly   581 VQRSTNKYLVDIFPHEMPM--DTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPK 643
            |..|.||::..||..::.|  :|.|:.|||..:|:.||::||||||...|:|:|||||||||:|.
Zfish   587 VHSSKNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPM 651

  Fly   644 NFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP-LEQCDCRKLARQICE 707
            .||:|||||||||||||||.||||||||||:.:..||:|||:|:|.|.| .:|.|.|...::|.|
Zfish   652 LFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIAE 716

  Fly   708 VALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQ 772
            ..|..|.|.|.||||:||:|..|..||::|.:.:...::.||:.:|....|....:.:::.:.:|
Zfish   717 AVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKMKKSAMLIQ 781

  Fly   773 RYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKL--- 834
            :.|||...|:.|..||.||.||.|...:::|...:.:.|.|.:..|...||:|||:.|:.:|
Zfish   782 KTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQTYHVARQRIMLFQGRCRGFLVRRAFRHRLWAV 846

  Fly   835 ----------LERRKQNQLKKE--ELLKLAKMKEAEELLRLQQLKEQ-KEREQREQQEKRLQEEQ 886
                      :.||...:||.|  ..|:..|::.|||    |:|:.| ..|:.:|:.||..||.
Zfish   847 ITIQAYTRGMIARRLYKRLKGEYRRRLEAEKLRLAEE----QKLRNQMSARKAKEEAEKMHQER- 906

  Fly   887 RLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTR 951
                       ||..|.:...|.|..:|||                          .|....:.:
Zfish   907 -----------LAQLAREDAEREKKERQEA--------------------------RRKMEMLDQ 934

  Fly   952 INTIPESPGTIDVESSKQMVDDVFRFLN----------------DEPDAALRKLNNISSGDTIRL 1000
            :....:.|     .:...|||.:|.||.                ::.:...|:|......:::.|
Zfish   935 MEKARQEP-----VNDSDMVDKMFGFLGTTNSFPGQEGQAPAGFEDLERTHRELEVEDLDESLPL 994

  Fly  1001 PKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGD 1065
            |:.  :..|.|::.:.|::||||.|.:|..:.|:|||:.||.||...|::|:.|:|:|:||||||
Zfish   995 PED--DLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQLAALAVWITVLRFMGD 1057

  Fly  1066 LPDVVSSPTLH--VFDNENLMSDLASLLNT--SDSYKPRLFVRQSQ------------------- 1107
            ||:    |..|  :.|....:..:..:..|  ..:||..|...|.:
Zfish  1058 LPE----PKYHTAISDGSEKIPVMTKIYETLGKKTYKRELQALQGEGENTNIESHKKSSVRHKLV 1118

  Fly  1108 -----------RRIPKPLASGEKEAQEFYQHWLNV----PTSHLEKIHFIIGHGIIKNSLRDEIL 1157
                       ..:.|.|..|     |:..|..::    |||:|||:|||||:||::..|||||.
Zfish  1119 SLTLKKKSKITEEVTKRLNDG-----EYTVHGNSMLEDRPTSNLEKLHFIIGNGILRPGLRDEIY 1178

  Fly  1158 AQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLV 1222
            .||||||..|||:||::|||:|:|||:.||.||::|..:||:|:.:|... .|....:||.||.|
Zfish  1179 CQICKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISEGPPG-YAPYCEERLRRTFV 1242

  Fly  1223 NGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGL 1287
            ||.|.||||..||.|.:.:.|:.|.:..|||..:.|..|:|:||:|..|.|...:.|.|.|||.|
Zfish  1243 NGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALSDKISLQDRFGFSL 1307

  Fly  1288 VMSLNGKLMPLGAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQL 1345
            .::|..|:..||:|.:||:||:|:|||       ::.:|||:|:.|||:|..|:||:.|..||.|
Zfish  1308 YIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEIFTPWHDPAEDAVATNL 1372

  Fly  1346 IYKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIEN 1410
            ||:||:.|:|.|||||..| |:|.:.:...:|:||...::....|.|.:::| |......:.:|.
Zfish  1373 IYQQIVRGVKFGEYRCDRE-DLAELASQQYYVDYGSEILVERLLSLIPSYIP-DREISSAKTVER 1435

  Fly  1411 WSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDEL 1475
            |::.|.|.::|..|.::.     ::.|| .||::..||...||:..||.:|..:..||.|..:::
Zfish  1436 WAQFIMAAHKKGVYTQKR-----VDPQK-VKEEVVDFARYKWPLLFSRFYEAFKFSGPSLPKNDV 1494

  Fly  1476 MLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKLHVMTF-----QHVNFVLQCSSAQDANE 1535
            ::.:|..|::.:||.||||....|.|:..|......||...:|     :...|....::|:|..:
Zfish  1495 IVAVNWTGVYFVDEQEQVLLELSFPEITAVSSSKGGKLQAQSFTLATIKADEFTFTSNNAEDIRD 1559

  Fly  1536 VINYMLDNLRQRSSYGVAL--DPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCV 1598
            ::...|:.||:||.:.|||  :|....|....|....||||..:.. ||.|:|..       |..
Zfish  1560 LVVTFLEGLRKRSKFVVALQDNPSPAADDSTFLSFLKGDLIVLDQD-TGEQVMTS-------GWA 1616

  Fly  1599 NG------QWGQFLAGNVRVLATLTKP-----------SEKLQDILREGRFQEPPKPTPRANYSR 1646
            :|      |.|.|.|..|.||.|:.:|           .::.|:.||....     |.......|
Zfish  1617 HGTNDRTKQRGDFPADCVYVLPTVVRPPHDVVAFVTMTPDQRQESLRISHV-----PALTETEER 1676

  Fly  1647 RRQHNISQLAESHFREPLDSDKAPLSKF--------------SPEPLKAPLLKAVVKVPPLFQQA 1697
            .:.:.:.:.:..:||.|   .|..||:.              :.||:|..|||.......|.|:|
Zfish  1677 VKPYTLEEFSYDYFRPP---PKHTLSRVMITKNRGKDKLWCCTREPIKQALLKKCGGHEELSQEA 1738

  Fly  1698 LVMHHHILKYMGDI-ARSNLPVN--TDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESEKRGWD 1759
            .:....::|||||. ::....||  ||.||:.||:...|.||:|||::|||::|....||::||:
Zfish  1739 CMAFIAVMKYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQILKQLTENHIKYSEEKGWE 1803

  Fly  1760 LLYLATGLVAPS-VLVMRELIILLRMRADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCL 1823
            ||:|..||..|| ||:......|...:...||..|::||:::|..|.||..|||:|||.||.:..
Zfish  1804 LLWLCVGLFPPSNVLLPHVQRFLQSKKHHPLALDCMQRLQKALRNGSRKYPPHLVEVEAIQHKTT 1868

  Fly  1824 HIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDF 1888
            .|:||:||||||.||||:||.|:..:...:|:.||.||:|.|:|:|:|..|:|.::||.:|.|||
Zfish  1869 QIFHKVYFPDDTDEAFEVESSTKAKDFCLNISSRLLLKTPEGFSLFVKISDKVISVPEGDFFFDF 1933

  Fly  1889 ITQLIYWLRQQRTIRSISDG-----QYQLHFMRKLWLNNHPGEDLNGDMIFSYPQELHKYLKGYY 1948
            :..|..|:::.|..:   ||     .||:.||:|||....||:|...|.||.|.|||.|||:||:
Zfish  1934 VRHLTDWIKKARPAK---DGIVPSLTYQVFFMKKLWTTTVPGKDSFADSIFHYYQELPKYLRGYH 1995

  Fly  1949 PIDCEQASRLAILVYSA---DHDVSLQRLPEVLTRLIPEDLIPLQTVAEWRQQILPKVHRDHL-- 2008
            ....|:..:|..|:|..   |.......:|::|..:||:|||...:..:|::.|:...:| |.
Zfish  1996 KCSREEVFQLGALIYRVKFEDDKSHFPSIPKMLKEMIPQDLIRQLSPDDWKRSIVAYFNR-HAGK 2059

  Fly  2009 TEDHAKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQ 2073
            :.:.||::||:.:..:..|||.||.|||..:...||.||||||..|..::||..|:||.:|.:::
Zfish  2060 SREEAKLMFLKIIFKWPTFGSAFFEVKQTTEPHFPEILLIAINKYGVSLIDPKNKDILTTYPFTK 2124

  Fly  2074 LGIWSSGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYV 2115
            :..||||..:|||..||::..|||||.|:.||||||||.||:
Zfish  2125 ISNWSSGNTYFHITIGNLVQGSKLLCETSLGYKMDDLLTSYI 2166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	404/687 (59%)
		MYSc_Myo7	81..726	CDD:276832	386/657 (59%)
		IQ	765..785	CDD:197470	5/19 (26%)
		DUF4355	827..>887	CDD:290964	22/75 (29%)
		MyTH4	1031..1239	CDD:295320	95/245 (39%)
		B41	1248..1429	CDD:214604	72/187 (39%)
		FERM_N	1248..>1288	CDD:286467	16/39 (41%)
		FERM_B-lobe	1342..1429	CDD:271216	30/86 (35%)
		PH-like	1454..1547	CDD:302622	26/97 (27%)
		MyTH4	1674..1819	CDD:214535	61/162 (38%)
		B41	1827..2032	CDD:214604	83/214 (39%)
		FERM_N	1829..>1877	CDD:286467	24/47 (51%)
		FERM_M	1936..2032	CDD:278785	32/100 (32%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	47/88 (53%)
myo7aa	XP_021323248.1	MYSc_Myo7	79..735	CDD:276832	386/657 (59%)
		IQ	772..793	CDD:197470	5/20 (25%)
		MAP7	<863..941	CDD:310345	26/119 (22%)
		UFD1	893..>1160	CDD:332114	74/320 (23%)
		MyTH4	1023..1259	CDD:214535	95/245 (39%)
		B41	1265..1479	CDD:214604	83/221 (38%)
		FERM_C1_MyoVII	1473..1571	CDD:270019	26/97 (27%)
		SH3	1572..1636	CDD:327375	22/71 (31%)
		MyTH4	1716..1864	CDD:214535	61/147 (41%)
		B41	1871..2083	CDD:214604	83/215 (39%)
		FERM_C2_MyoVII	2079..2174	CDD:270020	47/88 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D21221at33208
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920