Protein Alignment Myo28B1 and myo7aa

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_073784889.1
• Gene: myo7aa / 252846
• ZFINID: ZDB-GENE-020709-1
• Length: 2232
• Species: Danio rerio
• Alignment Length: 2268
• Identity: 932/2268 - (41%)
• Similarity: 1312/2268 - (57%)
• Gaps: 252/2268 - (11%)

  Fly    10 GEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV--LKAMHITSQEDVEDM 72
            |:|||: ...|..||.||.||.:...:..|..|.||...:.|:...:.  :|.||.||...||||
Zfish    36 GDYVWL-DLKTGHEFEVPIGAVVKLCDSGQIQVLDDEGNEHWISPQNATNIKPMHPTSIHGVEDM 99

  Fly    73 ITLGDLQEYTILRNLQNRYAKQLIY------TYTGSMLVAINPYQILPIYTNREIQLYRNKSLAE 131
            |.||||.|..|||||..||.:.|||      |||||:|||:||||:|||||..:|:||.||.:.|
Zfish   100 IRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTNKKIGE 164

  Fly   132 LPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANP 196
            :|||||||:||.:..:||..::||.:||||||||||||||||||:||||||:|||||||::||||
Zfish   165 MPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEANP 229

  Fly   197 IMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCML 261
            |:||||||||:||||||||||||:|.|..:|||:||:|:||||||||:..|:|||||||||||||
Zfish   230 ILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQARDERNYHIFYCML 294

  Fly   262 AGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLL 326
            .|::..::::|.|.:  .:.|.||..|.|....||.|.|::::||:|||||.|..:|.|.|..||
Zfish   295 KGMTPDQKKQLGLSK--ATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTDKENWEISKLL 357

  Fly   327 AAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLS 391
            |||||:||||:.|....||...|:.....|...|.||.:.:..|...||.|||...||.|:|.||
Zfish   358 AAILHMGNLRYEARTYDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLTSRTIITRGETVSTPLS 422

  Fly   392 KEAAIEGRDAFVKSLYDGIFVRIVRRINETINK----QVDQPMNSIGVLDIFGFENFDNNSFEQL 452
            .|.|::.||||||.:|..:||.||.:||..|.|    ::.....|||:|||||||||..||||||
Zfish   423 IEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRSIGLLDIFGFENFMVNSFEQL 487

  Fly   453 CINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFP 517
            |||:||||||||||.|:||:||:||..|:||||||||.|||..||:|.:||||::||||||||||
Zfish   488 CINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFP 552

  Fly   518 KGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQ 582
            ||||.|:|.||:.||...:.|:..|.|..:.|||:|:||||.|...||||||||:..||:..||.
Zfish   553 KGTDTTMLNKLNSQHKLNTNYIPPKNTYETQFGIQHFAGVVYYETRGFLEKNRDTLHGDIIQLVH 617

  Fly   583 RSTNKYLVDIFPHEMPM--------------------DTAKKQPTLCVKFRNSLDMLMRTLSQAH 627
            .|.||::..||..::.|                    :|.|:.|||..:|:.||::||||||...
Zfish   618 SSKNKFIKQIFQADVAMFLCGYWSDSLGKAGSLHKGAETRKRSPTLSSQFKRSLELLMRTLSVCQ 682

  Fly   628 PYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP 692
            |:|:|||||||||:|..||:|||||||||||||||.||||||||||:.:..||:|||:|:|.|.|
Zfish   683 PFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKP 747

  Fly   693 -LEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVL 756
             .:|.|.|...::|.|..|..|.|.|.||||:||:|..|..||::|.:.:...::.||:.:|...
Zfish   748 AYKQEDLRGTCQRIAEAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFK 812

  Fly   757 FRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALS 821
            .|....:.:::.:.:|:.|||...|:.|..||.||.||.|...:::|...:.:.|.|.:..|...
Zfish   813 DRSNFLKMKKSAMLIQKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQTYHVARQRIMLFQGRC 877

  Fly   822 RGYLVRKDFQKKL-------------LERRKQNQLKKE--ELLKLAKMKEAEELLRLQQLKEQ-K 870
            ||:|||:.|:.:|             :.||...:||.|  ..|:..|::.|||    |:|:.| .
Zfish   878 RGFLVRRAFRHRLWAVITIQAYTRGMIARRLYKRLKGEYRRRLEAEKLRLAEE----QKLRNQMS 938

  Fly   871 EREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTL 935
            .|:.:|:.||..||.            ||..|.:...|.|..:|||
Zfish   939 ARKAKEEAEKMHQER------------LAQLAREDAEREKKERQEA------------------- 972

  Fly   936 IVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLN----------------DEPDA 984
                   .|....:.::....:.|     .:...|||.:|.||.                ::.:.
Zfish   973 -------RRKMEMLDQMEKARQEP-----VNDSDMVDKMFGFLGTTNSFPGQEGQAPAGFEDLER 1025

  Fly   985 ALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDE 1049
            ..|:|......:::.||:.  :..|.|::.:.|::||||.|.:|..:.|:|||:.||.||...|:
Zfish  1026 THRELEVEDLDESLPLPED--DLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQ 1088

  Fly  1050 MASKAIWLTILRFMGDLPDVVSSPTLH--VFDNENLMSDLASLLNT--SDSYKPRLFVRQSQ--- 1107
            :|:.|:|:|:||||||||:    |..|  :.|....:..:..:..|  ..:||..|...|.:
Zfish  1089 LAALAVWITVLRFMGDLPE----PKYHTAISDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEN 1149

  Fly  1108 ---------------------------RRIPKPLASGEKEAQEFYQHWLNV----PTSHLEKIHF 1141
                                       ..:.|.|..|     |:..|..::    |||:|||:||
Zfish  1150 THIESHKKSSVRHKLVSLTLKKKSKITEEVTKRLNDG-----EYTVHGNSMLEDRPTSNLEKLHF 1209

  Fly  1142 IIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTA 1206
            |||:||::..|||||..||||||..|||:||::|||:|:|||:.||.||::|..:||:|:.:|..
Zfish  1210 IIGNGILRPGLRDEIYCQICKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISEGPP 1274

  Fly  1207 QLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVN 1271
            . .|....:||.||.|||.|.||||..||.|.:.:.|:.|.:..|||..:.|..|:|:||:|..|
Zfish  1275 G-YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCN 1338

  Fly  1272 QLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEM 1329
            .|...:.|.|.|||.|.::|..|:..||:|.:||:||:|:|||       ::.:|||:|:.|||:
Zfish  1339 ALSDKISLQDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEI 1403

  Fly  1330 FATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITA 1394
            |..|:||:.|..||.|||:||:.|:|.|||||..| |:|.:.:...:|:||...::....|.|.:
Zfish  1404 FTPWHDPAEDAVATNLIYQQIVRGVKFGEYRCDRE-DLAELASQQYYVDYGSEILVERLLSLIPS 1467

  Fly  1395 FVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRL 1459
            ::| |......:.:|.|::.|.|.::|..|.::.     ::.|| .||::..||...||:..||.
Zfish  1468 YIP-DREISSAKTVERWAQFIMAAHKKGVYTQKR-----VDPQK-VKEEVVDFARYKWPLLFSRF 1525

  Fly  1460 FEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKLHVMTF-----Q 1519
            :|..:..||.|..:::::.:|..|::.:||.||||....|.|:..|......||...:|     :
Zfish  1526 YEAFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSSKGGKLQAQSFTLATIK 1590

  Fly  1520 HVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVAL--DPVVEGDLEDCLVLNPGDLIEFEAGVTG 1582
            ...|....::|:|..:::...|:.||:||.:.|||  :|....|....|....||||..:.. ||
Zfish  1591 ADEFTFTSNNAEDIRDLVVTFLEGLRKRSKFVVALQDNPSPAADDSTFLSFLKGDLIVLDQD-TG 1654

  Fly  1583 AQLMAGNAQDCYRGCVNG------QWGQFLAGNVRVLATLTKP-----------SEKLQDILREG 1630
            .|:|..       |..:|      |.|.|.|..|.||.|:.:|           .::.|:.||..
Zfish  1655 EQVMTS-------GWAHGTNDRTKQRGDFPADCVYVLPTVVRPPHDVVAFVTMTPDQRQESLRIS 1712

  Fly  1631 RFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAPLSKF--------------SPEPLKA 1681
            ..     |.......|.:.:.:.:.:..:||.|   .|..||:.              :.||:|.
Zfish  1713 HV-----PALTETEERVKPYTLEEFSYDYFRPP---PKHTLSRVMITKNRGKDKLWCCTREPIKQ 1769

  Fly  1682 PLLKAVVKVPPLFQQALVMHHHILKYMGDI-ARSNLPVN--TDLIFQPALQHPLLCDELYCQLMK 1743
            .|||.......|.|:|.:....::|||||. ::....||  ||.||:.||:...|.||:|||::|
Zfish  1770 ALLKKCGGHEELSQEACMAFIAVMKYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQILK 1834

  Fly  1744 QLSDNPSSESEKRGWDLLYLATGLVAPS-VLVMRELIILLRMRADALADACLKRLKRSLAQGQRK 1807
            ||::|....||::||:||:|..||..|| ||:......|...:...||..|::||:::|..|.||
Zfish  1835 QLTENHIKYSEEKGWELLWLCVGLFPPSNVLLPHVQRFLQSKKHHPLALDCMQRLQKALRNGSRK 1899

  Fly  1808 KAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIFLKT 1872
            ..|||:|||.||.:...|:||:||||||.||||:||.|:..:...:|:.||.||:|.|:|:|:|.
Zfish  1900 YPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCLNISSRLLLKTPEGFSLFVKI 1964

  Fly  1873 GDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSISDG-----QYQLHFMRKLWLNNHPGEDLNGDM 1932
            .|:|.::||.:|.|||:..|..|:::.|..:   ||     .||:.||:|||....||:|...|.
Zfish  1965 SDKVISVPEGDFFFDFVRHLTDWIKKARPAK---DGIVPSLTYQVFFMKKLWTTTVPGKDSFADS 2026

  Fly  1933 IFSYPQELHKYLKGYYPIDCEQASRLAILVYSA---DHDVSLQRLPEVLTRLIPEDLIPLQTVAE 1994
            ||.|.|||.|||:||:....|:..:|..|:|..   |.......:|::|..:||:|||...:..:
Zfish  2027 IFHYYQELPKYLRGYHKCSREEVFQLGALIYRVKFEDDKSHFPSIPKMLKEMIPQDLIRQLSPDD 2091

  Fly  1995 WRQQILPKVHRDHL--TEDHAKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHM 2057
            |::.|:...:| |.  :.:.||::||:.:..:..|||.||.|||..:...||.||||||..|..:
Zfish  2092 WKRSIVAYFNR-HAGKSREEAKLMFLKIIFKWPTFGSAFFEVKQTTEPHFPEILLIAINKYGVSL 2155

  Fly  2058 LDPTTKEILRSYEYSQLGIWSSGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYV 2115
            :||..|:||.:|.::::..||||..:|||..||::..|||||.|:.||||||||.||:
Zfish  2156 IDPKNKDILTTYPFTKISNWSSGNTYFHITIGNLVQGSKLLCETSLGYKMDDLLTSYI 2213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	386/675 (57%)
		IQ	765..785	CDD:197470	5/19 (26%)
		Atrophin-1	<820..>946	CDD:460830	35/141 (25%)
		MyTH4	1031..1239	CDD:470587	95/245 (39%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	40/97 (41%)
		B41	1248..1429	CDD:214604	72/187 (39%)
		PH-like	1454..1547	CDD:473070	26/97 (27%)
		MyTH4	1674..1819	CDD:214535	61/162 (38%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	44/98 (45%)
		B41	1827..2032	CDD:214604	83/214 (39%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	47/88 (53%)
myo7aa	XP_073784889.1	None