Protein Alignment Myo28B1 and Myo5b

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_008770307.1
• Gene: Myo5b / 25132
• RGDID: 621347
• Length: 1854
• Species: Rattus norvegicus
• Alignment Length: 1904
• Identity: 500/1904 - (26%)
• Similarity: 819/1904 - (43%)
• Gaps: 431/1904 - (22%)

  Fly    71 DMITLGDLQEYTILRNLQNRYAK-QLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPP 134
            |:..|..|.|..:|.||:.|:.: ..||||.|.:|||||||:.||||....|..|..:::.::.|
  Rat    81 DLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDP 145

  Fly   135 HIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHS--WIEQQIIEANPI 197
            ||||:::.|::::.|.::||.:::|||||||||.|.|..::|.|.:.|..|  .||::::.::||
  Rat   146 HIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLASSPI 210

  Fly   198 MEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLA 262
            |||.|||||.||||||||||||||.|..:..|.||.::.|||||||:|||:.|||||||||.:.|
  Rat   211 MEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCA 275

  Fly   263 GLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLA 327
            ..|..|.:.|.|  .....:.|.|.||..|:.|..||:||...|.|:.:|..:.....||..::|
  Rat   276 AASLPEFKELAL--TCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKIIA 338

  Fly   328 AILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSK 392
            :|||||::...|....:..:....| .:|....:||||..|.:...|..|.:....|....::|.
  Rat   339 SILHLGSVEIQAERDGDSCSISPQD-EHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTMSL 402

  Fly   393 EAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYA 457
            :..:..|:|..|.:|..:|..||..||:.:...:.| .:.||||||:|||.|:.|||||.|||||
  Rat   403 QQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQ-HSFIGVLDIYGFETFEINSFEQFCINYA 466

  Fly   458 NENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQ 522
            ||.|||.|..|:||:||:||..|.|.|..|:|.|||..:|||..| :.::.|:|||.|.||||||
  Rat   467 NEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAK-LGILDLLDEECKVPKGTDQ 530

  Fly   523 TLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNK 587
            ...:||:.:|.|...:.|.:.:.|: |.:.|:|..|.|...||||||||:...:...:::.|...
  Rat   531 NWAQKLYERHSNSQHFQKPRMSNTA-FIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFP 594

  Fly   588 YLVDIFPHE---MP-MDTAK----------------KQP------TLCVKFRNSLDMLMRTLSQA 626
            .:.|:|..:   :| .:|||                |.|      ::..:||.||::||.||:..
  Rat   595 LVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLMETLNAT 659

  Fly   627 HPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVG 691
            .|:::||||||:.|.|.:||.:..|:|||..|::||.||..||||.|..|..|..|||:|:....
  Rat   660 TPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRE 724

  Fly   692 PLEQCDCRKLARQICEVALPADSDR-QYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRV 755
            .....|.:.:.:.:.| :|..|.|: |:|:||:|.|....|.||..|:....::.:.||:.:|..
  Rat   725 LANTTDKKNICKSVLE-SLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKTVRGW 788

  Fly   756 LFRRYMKRYREAIITVQRYWRGRLQRR----------------KYQVM--RQGFHRLGACIAAQQ 802
            |.|...:|.|.|.:|:||:.||.|.||                :|:::  |:.:.|:.......|
  Rat   789 LQRVKYRRLRAATLTLQRFCRGYLARRLTEHLRRTRAAIVFQKQYRMLKARRAYCRVRRAAVIIQ 853

  Fly   803 LTTKFTMVRCRTIK----------LQALSRGYLVRKDFQKK----LLERRKQNQLKKEELLKLAK 853
            ..|:...|| |:.:          :|..:||::.|:.||::    ::.:....:||..:.||..|
  Rat   854 SYTRAMCVR-RSYRQVLTEHKATIIQKYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALK 917

  Fly   854 M--KEAEELLRL------QQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTK 910
            :  :.||.|.||      :.::.|::.:.:.::.|.|.|:.     :|..:..||...:.|:...
  Rat   918 IEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQL-----SAVTSTHAMEVEKLKKELA 977

  Fly   911 PVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRI--NTIPESPGTI-----DVESSK 968
            ..:|.....|:||.:..:....|.|        :.|.:..|:  :|.....|.:     |:|...
  Rat   978 RYQQNQEADPSLQLQEEVQSLRTEL--------QKAHSERRVLEDTHNRENGELRKRVADLEHEN 1034

  Fly   969 QMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYF---------- 1023
            .::.|....||::   .||:....||..::.....:...::.....|......|.
  Rat  1035 ALLKDEKEHLNNQ---ILRQSKAESSQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLR 1096

  Fly  1024 GGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLA 1088
            ....|..|.:.|..:|.|:.:.....:::..|        ||..|.:..  :.....|....|:.
  Rat  1097 DEQQTPGHRKNPSNQSSLESDSNYPSISTSEI--------GDTEDALQQ--VEEIGIEKAAMDMT 1151

  Fly  1089 SLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFI-IGHGIIK--- 1149
            ..|      |.:..||:.::...|.....|||.|:..:..:....:.|:..... |.:..:|
  Rat  1152 VFL------KLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDVDQDADIAYNSLKRQE 1210

  Fly  1150 ------------NSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMK 1202
                        |.||..:..|..:....:.|..|||   |||:.                  :|
  Rat  1211 LESENKKLKNDLNELRKAVADQAMQDNSTHSSPDSYS---LLLNQ------------------LK 1254

  Fly  1203 QGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRL-------QV 1260
            ....:|:.     |.|..|:                       |...:|:..||||       .:
  Rat  1255 LANEELEV-----RKEEVLI-----------------------LRTQIMNADQRRLSGKNMEPNI 1291

  Fly  1261 DAAST------------AREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECE 1313
            :|.::            |.||.:.:||....|:.:|:   ::.:|:|.....|.:.|
  Rat  1292 NARTSWPNSEKHVDQEDAIEAYHGVCQTNSQTEDWGY---LNEDGELGLAYQGLKQV-------- 1345

  Fly  1314 QRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKD-------IAMVC 1371
            .|.|:|                   ..:|..|.:::.:..||......:.|.|       ..::.
  Rat  1346 ARLLEA-------------------QLQAQNLKHEEEVEHLKAQVEAMKEEMDKQQQTFCQTLLL 1391

  Fly  1372 ALACFVEYG-PGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLE 1435
            :....||:| ..||.||....:......:.|...|:.::...::         |:|:.|:  |..
  Rat  1392 SPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKI---------YMKKVQD--LEA 1445

  Fly  1436 AQKRAKEDICLFAHLSWPMRH---SRLFEVVRKEG------PKLQSDELMLGINSAGLFLIDETE 1491
            ||..|:.|          .||   :|...|.|||.      ...:.||.:|..|    .:.|...
  Rat  1446 AQALAQSD----------RRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRN----LVTDLKP 1496

  Fly  1492 QVLAS---CCFSEVLKV------HVESDDKLHVMTFQHVNFVLQCSSAQDAN-EVINYMLDNLRQ 1546
            |:|:.   |..:.:|.:      :...|.|:|.:....:|.:.:.....:.: |:.::.|.|..:
  Rat  1497 QMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHNEDFEMTSFWLSNTCR 1561

  Fly  1547 RSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVR 1611
                           |..||....||
  Rat  1562 ---------------LLHCLKQYSGD--------------------------------------- 1572

  Fly  1612 VLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAPLSKFSP 1676
                             ||...:        |.:::.:|.:.....:.:|:.| ||
  Rat  1573 -----------------EGFMTQ--------NTAKQNEHCLKNFDLTEYRQVL-SD--------- 1602

  Fly  1677 EPLKAPLLKAVVKV-----PPLFQQALVMHHHI-----LKYMGDIARSNLPVNTD-------LIF 1724
              |...:.:.::|:     .|:...|::.:..|     ::..|...||:..|:.:       :|.
  Rat  1603 --LSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAIIR 1665

  Fly  1725 QPALQHPLLCD-----ELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRM 1784
            |....|.:|||     |:..|:.||               |.|:...:...::|          :
  Rat  1666 QMNFFHTVLCDQGLDPEIILQVFKQ---------------LFYMINAVTLNNLL----------L 1705

  Fly  1785 RADALADACLKRLKRSLAQ 1803
            |.||.:.:...:|:.:::|
  Rat  1706 RKDACSWSTGMQLRYNISQ 1724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	276/674 (41%)
		IQ	765..785	CDD:197470	10/35 (29%)
		Atrophin-1	<820..>946	CDD:460830	29/137 (21%)
		MyTH4	1031..1239	CDD:470587	38/223 (17%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	21/109 (19%)
		B41	1248..1429	CDD:214604	37/207 (18%)
		PH-like	1454..1547	CDD:473070	23/111 (21%)
		MyTH4	1674..1819	CDD:214535	27/152 (18%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myo5b	XP_008770307.1	MYSc_Myo5	91..759	CDD:276831	276/674 (41%)
		IQ	773..795	CDD:197470	5/21 (24%)
		IQ	821..842	CDD:197470	2/20 (10%)
		IQ	871..891	CDD:197470	4/19 (21%)
		SMC_prok_B	906..>1268	CDD:274008	77/419 (18%)
		Myo5b_CBD	1480..1851	CDD:271261	56/365 (15%)