DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and MYO16

DIOPT Version :10

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_001185879.1 Gene:MYO16 / 23026 HGNCID:29822 Length:1880 Species:Homo sapiens


Alignment Length:1369 Identity:361/1369 - (26%)
Similarity:548/1369 - (40%) Gaps:408/1369 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 EDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLY---RNKSLAE 131
            :|:.||.:|.:.::|..:|.|:....|||:.|.:|:.:|||:.||||::...|||   ..|..:.
Human   426 DDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSS 490

  Fly   132 LPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISG-KHSWIEQQIIEAN 195
            ||||:|:..:.||.:|.|.:..||.::|||.|:||:|::|.|:::|...:| ..:.::.:.....
Human   491 LPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVV 555

  Fly   196 PIMEAFGNAKTVRNDNSSRFGKYIEIRFTP-QGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYC 259
            .|:||||:|||..||.||.|.||.|::|.. :..:.||||..|||||||:|.|...:.|:.|||.
Human   556 CILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYL 620

  Fly   260 MLAGLSTAERERLKLQEQSPSQY-HYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSIL 323
            ::.|||..|:..|.|......:| :...|....|.....:.:..|.::.|:.|:.|...||.::.
Human   621 LMDGLSAEEKYGLHLNNLCAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVENLF 685

  Fly   324 SLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTT 388
            .:||||||||::||||....|  :|.:.|...|::||.:|.:....|.:|||....:..|:.:..
Human   686 VILAAILHLGDIRFTALNEGN--SAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIR 748

  Fly   389 SLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMN---SIGVLDIFGFENFDNNSFE 450
            ..:.:.|...||...||||..:|..:|..:|..::.|.:|...   .||:|||||||.|..|.||
Human   749 RHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFE 813

  Fly   451 QLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQ-ILDLIGMKPMNLMSLIDEES 514
            |||:|..||.:..:....:|..||.|...|.:..:......||. :||....||...::|:||||
Human   814 QLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEES 878

  Fly   515 K--------FPKGTDQTLLEKLH-------VQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLG 564
            :        |||.. |:|||..:       ::.||.::.:|...|   .|.|.||||.|||:.:|
Human   879 QMIWSVESNFPKKL-QSLLESSNTNAVYSPMKDGNGNVALKDHGT---AFTIMHYAGRVMYDVVG 939

  Fly   565 FLEKNRDSFSGDLRTLVQRSTNKY--------------LVDIFP------HEMPMDTAKKQP--- 606
            .:|||:||.|.:|..:::.|.|..              ||..:|      |:..: .:||..   
Human   940 AIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSAL-LSKKMTASS 1003

  Fly   607 ---------------------------------TLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNE 638
                                             |:..:.|.||..::..|.:..|:||.||:||.
Human  1004 IIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNN 1068

  Fly   639 YKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPV-------GPLEQC 696
            .|.|..||......||:|.|::|..:|.|.|||:|.::..|:.||:.|....       ...|:|
Human  1069 SKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERC 1133

  Fly   697 DCRKLARQICEVALPADSDRQYGKTKLFLR----DE-DDASLELQRSQLMLKSIVTIQRGIRRVL 756
               :|..|.|::     ...|.|..|:||:    |: :|..|:|||      .|:|.|:.||..|
Human  1134 ---RLVLQQCKL-----QGWQMGVRKVFLKYWHADQLNDLCLQLQR------KIITCQKVIRGFL 1184

  Fly   757 FRRY--------------------------MKRYREAII----TVQR------------YWRGRL 779
            .|::                          :|.|...:|    .:.|            |.:.:|
Human  1185 ARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKL 1249

  Fly   780 QRRKYQVMRQG------------FH-----------RLGACIA-----AQQLTTKFTMVRCRTIK 816
            :.|..|  .:|            ||           .||.|:.     :..|.:.|:|       
Human  1250 EVRNMQ--EEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSM------- 1305

  Fly   817 LQALSRGYLVRKDFQKKLLERRKQ--NQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQE 879
                        |....|...|||  .:.|::...:|:...||....    |...:|        
Human  1306 ------------DDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSAC----LSAARE-------- 1346

  Fly   880 KRLQEEQRLKAEAAARNALAMAAVQQKRRTKP-------VKQEAPKAPTLQARNSLPPPPTTLIV 937
                         ||..|||        |.:|       :|:..|:.|.......|......:..
Human  1347 -------------AANEALA--------RPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISG 1390

  Fly   938 AAPLPTRPA---SAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIR 999
            :.|...|||   .|..|:.|    |||                    |..||.            
Human  1391 SRPGDARPAGAPGAAARVLT----PGT--------------------PQCALP------------ 1419

  Fly  1000 LPKSVPNNIDTSDFSYLK---YAA----------TYF------------GGGATAQHERKPLKKS 1039
             |.:.|.:.|.|:..|::   :||          .|.            |.|:...|...|    
Human  1420 -PAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASP---- 1479

  Fly  1040 LLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVR 1104
            .|.|..|.||.|...         ||..|:  .|..     .||:           .::|.|.|.
Human  1480 PLLHRAPEDEAAGPP---------GDACDI--PPPF-----PNLL-----------PHRPPLLVF 1517

  Fly  1105 QSQRRIPKPL----ASGEKEAQEFYQHWLNVPTSHLE--KIHFIIGHGIIKNSLRDEILAQICKQ 1163
            .     |.|:    ||.|.            |.:.||  |:      .:::.:|:..:       
Human  1518 P-----PTPVTCSPASDES------------PLTPLEVKKL------PVLETNLKYPV------- 1552

  Fly  1164 LYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGP-RC 1227
               .|..||               |.|.::     |..::|.....|:|.|     .|.||. |.
Human  1553 ---QPEGSS---------------PLSPQY-----SKSQKGDGDRPASPGL-----ALFNGSGRA 1589

  Fly  1228 QPPS 1231
            .|||
Human  1590 SPPS 1593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc_Myo7 81..726 CDD:276832 237/732 (32%)
IQ 765..785 CDD:197470 5/35 (14%)
Atrophin-1 <820..>946 CDD:460830 24/134 (18%)
MyTH4 1031..1239 CDD:470587 44/208 (21%)
FERM1_F1_Myosin-VII 1243..1334 CDD:340612
B41 1248..1429 CDD:214604
PH-like 1454..1547 CDD:473070
MyTH4 1674..1819 CDD:214535
FERM2_F1_Myosin-VII 1825..1919 CDD:340613
B41 1827..2032 CDD:214604
FERM_C2_MyoVII 2028..2121 CDD:270020
MYO16NP_001185879.1 ANKYR 67..347 CDD:440430
ANK repeat 86..112 CDD:293786
ANK repeat 114..145 CDD:293786
ANK repeat 147..178 CDD:293786
ANK repeat 180..210 CDD:293786
ANK repeat 243..274 CDD:293786
ANK repeat 276..307 CDD:293786
ANK repeat 309..335 CDD:293786
MYSc_Myo16 437..1155 CDD:276844 237/732 (32%)
NYAP_N 1243..1590 CDD:464717 99/526 (19%)
NYAP_C 1652..1880 CDD:464724
Blue background indicates that the domain is not in the aligned region.

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