Protein Alignment Myo28B1 and myo-2

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 2102
• Identity: 529/2102 - (25%)
• Similarity: 848/2102 - (40%)
• Gaps: 521/2102 - (24%)

  Fly    45 DRNKQFWVP--------------AG-----------------DVLKAMHITSQEDVEDMITLGDL 78
            |..|..|:|              ||                 ||::.|:....|..|||..|..|
 Worm    28 DSKKNVWIPDSEDGYIEGVITKTAGDNVTVSIGQGAEKTVKKDVVQEMNPPKFEKTEDMSNLTFL 92

  Fly    79 QEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNA 143
            .:.::|.||:.|||..|||||:|...|.||||:.|||||:...:::..|...|:|||:||:||.|
 Worm    93 NDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEMPPHLFAVSDEA 157

  Fly   144 FQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISG-------------------KHSWIEQ 189
            ::.:.:..|||.::|:|||||||||:||.::.|.||:..                   |...:|.
 Worm   158 YRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAKKAATEEDKNKKKVTLED 222

  Fly   190 QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNY 254
            ||::.||::|||||||||||:|||||||:|.|.|:.||.:....|:.|||||||::.|:..||.|
 Worm   223 QIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGERCY 287

  Fly   255 HIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEV 319
            ||||.:.:......::.| |..:....|.::||.. ..:.|..|.::......|..:|.|.|.|.
 Worm   288 HIFYQVFSDYLPNLKKDL-LLNKPVKDYWFIAQAE-LIIDGINDKEEHQLTDEAFDILKFTPTEK 350

  Fly   320 WSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGE 384
            .....|:||::|:||::|  .:......||.|.|.:.:|.|:..||.......|||:..:.|..|
 Worm   351 MECYRLVAAMMHMGNMKF--KQRPREEQAEPDGTDDAERAAKCFGIDSEEFLKALTRPRVKVGNE 413

  Fly   385 HVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSF 449
            .|....:.|.......|..|.||..||..:|::.|:|::::.....:.||||||.|||.||.|||
 Worm   414 WVNKGQNIEQVNWAVGAMAKGLYSRIFNWLVKKCNQTLDQKGISRDHFIGVLDIAGFEIFDFNSF 478

  Fly   450 EQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMKPMNLMSLIDEE 513
            |||.||:.||.|||||..|:|.:||:||..|.|.|..|:| .|.|..::|| .||:.:::::|||
 Worm   479 EQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELI-EKPLGIIAMLDEE 542

  Fly   514 SKFPKGTDQTLLEKLHVQH-GNRSIY-----VKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDS 572
            ...||.||.||.:||..|| |....:     .|||..:.. |.:|||||.|.||.|.:||||:|.
 Worm   543 CIVPKATDLTLAQKLIDQHLGKHPNFEKPKPPKGKQAEAH-FAMRHYAGTVRYNCLNWLEKNKDP 606

  Fly   573 FSGDLRTLVQRSTNKYLV-----DIFPHEMPMDTAKKQP-------------TLCVKFRNSLDML 619
            .:..:.|:::.|....|:     |....|.....|.|..             |:.:.:|.||:.|
 Worm   607 LNDTVVTVMKASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFMTVSMLYRESLNKL 671

  Fly   620 MRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYR 684
            |..|...||:|||||.|||.|.....|..|.:.||..:|::|..||.|.|:|.|..:..||:||.
 Worm   672 MTMLHSTHPHFIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYA 736

  Fly   685 LLVPPVGPLEQCDCRK-----LARQICEVALPADSDRQYGKTKLF-----------LRDEDDASL 733
            ||......:.:.|.:|     |||.:.|..|..::.| .|.||:|           |||:..|.|
 Worm   737 LLAADESIIGKTDAKKGSALMLARLVKEKKLEEENFR-VGLTKVFFKAGIVAHLEDLRDQSLAQL 800

  Fly   734 ---------------ELQRSQLMLKSIVTIQRGIRR-------VLFRRYMK-------------- 762
                           |.:|....:.::..|||.||.       |.|:.|.|
 Worm   801 ITGLQAQIRWYYQTIERKRRVEKITALKIIQRNIRSWAELRTWVWFKLYGKVKPLVNSGKIEAQY 865

  Fly   763 -RYREAIIT-----VQRYWRGRLQRRKYQVMRQGFHRLG---ACIAAQ---------QLTTKFTM 809
             :.:|.:.|     ||       :..|.:.:::|..||.   |.:.||         ::..:.|.
 Worm   866 EKLQETVATLKDTVVQ-------EEEKKRQLQEGAERLNKETADLLAQLEASKGSTREVEERMTA 923

  Fly   810 VRCRTIKLQA----------LSRGYLVRKDFQKKLLERR----KQN------QLKKEELLKLAK- 853
            :..:.:.|:.          :.....|..:.||||:|..    |:|      .|:|.|..|.||
 Worm   924 MNEQKVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDLSLRKVEAEKNAKE 988

  Fly   854 --MKEAEELLRLQQ---LKEQKEREQREQQEKRLQEE-QRLKAEAAARNALAMAAVQ-------- 904
              ::..::.:|.|.   .|..|||:.:|:|.|:|.|: |..:.:..|.|.|....:|
 Worm   989 HQIRALQDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKAKLMQSLEDSEQT 1053

  Fly   905 ---QKRRTKPVKQEAPKA--------PTLQ--------ARNSLPPPPTTLIVAAPLPTRPASAVT 950
               :||....:.:...||        .||:        |.|:|....|.|...........:||.
 Worm  1054 MEREKRNRADMDKNKRKAEGELKIAQETLEELNKSKSDAENALRRKETELHTLGMKLEDEQAAVA 1118

  Fly   951 RINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGD------------------- 996
            ::..        .::..:..|.|:...|.||.||  |:..:.|..|
 Worm  1119 KLQK--------GIQQDEARVKDLHDQLADEKDA--RQRADRSRADQQAEYDELTEQLEDQARAT 1173

  Fly   997 --TIRLPK-------SVPNNIDTSDFSYLKYAATYFGGGATA-----------QHERKPLKKSLL 1041
              .|.|.|       .:..:::.|...:.:........|:.|           |.::..::|...
 Worm  1174 AAQIELGKKKDAELTKLRRDLEESGLKFGEQLTVLKKKGSDAIQELSDQIEQLQKQKGRIEKEKG 1238

  Fly  1042 KHEHPIDEMASK------------------AIWLTILRFMGD-----LPDVVSSPTLHVFDNENL 1083
            ..:...||.::.                  .:.|..||...|     |.|.|||......:|.:|
 Worm  1239 HMQREFDESSAALDQEAKLRADQERIAKGYEVRLLELRLKADEQSRQLQDFVSSKGRLNSENSDL 1303

  Fly  1084 ---MSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTS---HLEKIHFI 1142
               :.:|.:.:..::..|     .|....:.......|:|::| .|:..|:..:   .||:
 Worm  1304 ARQVEELEAKIQAANRLK-----LQFSNELDHAKRQAEEESRE-RQNLSNLSKNLARELEQ---- 1358

  Fly  1143 IGHGIIKNSLRDEILA------QICK-QLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSF 1200
                 :|.|:.||:..      |:.| .:.|:..|:.:....|:         .:.||: .::..
 Worm  1359 -----LKESIEDEVAGKNEASRQLSKASVELDQWRTKFETEGLI---------GADEFD-EVKKR 1408

  Fly  1201 MKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRL------------------- 1246
            ..|.|:::|........:...:...|.:..:..:.:.:...|..:.
 Worm  1409 QNQKTSEIQDALDACNAKIVALENARSRLTAEADANRLEAEHHAQAVSSLEKKQKAFDKVIDEWK 1473

  Fly  1247 ----DIHL-MDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVL 1306
                |::| :||.||    ||...:.||.....|...|.|.     |..|..:...|......:.
 Worm  1474 KKVDDLYLELDGAQR----DARQLSGEAHKLRGQHDTLADQ-----VEGLRRENKSLSDETRDLT 1529

  Fly  1307 DAISECEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVC 1371
            :::|| ..|...|..|...|.||..                :::..||...|....||:..|:.|
 Worm  1530 ESLSE-GGRATHALSKNLRRLEMEK----------------EELQRGLDEAEAALESEESKALRC 1577

  Fly  1372 ALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRL-------IAATYEKSSYVKEEQ 1429
                          :::.|:|.|.: ...:|..|...||..::       |.||.:..:..|.|
 Worm  1578 --------------QIEVSQIRAEI-EKRIAEKEEEFENHRKVHQQTIDSIQATLDSETKAKSE- 1626

  Fly  1430 NDLLLEAQKRAKEDICLFAHLSWPMRHS------------RLFEVVRKEGPKLQSDELMLGINSA 1482
               |...:|:.:.||   ..|...:.|:            |..:.:|    :||.
 Worm  1627 ---LFRVKKKLEADI---NELEIALDHANKANEDAQKNIRRYLDQIR----ELQQ---------- 1671

  Fly  1483 GLFLIDETEQVLASCCFSEVLKVH-VESDDKLHVMTFQHVNFVLQCSSAQDANEVINYML----D 1542
               .:||.::      ..|..:.| :.::.||.|...:....:::..:.:.|..|:...:    :
 Worm  1672 ---TVDEEQK------RREEFREHLLAAERKLAVAKQEQEELIVKLEALERARRVVESSVKEHQE 1727

  Fly  1543 NLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLA 1607
            :..:.:|..||| ...:..|::.:.|...|:.|....::.::                ..|:..|
 Worm  1728 HNNELNSQNVAL-AAAKSQLDNEIALLNSDIAEAHTELSASE----------------DRGRRAA 1775

  Fly  1608 GNVRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAPLS 1672
            .:...||         :|:                   |..|....||  ..|::.|:|....|.
 Worm  1776 SDAAKLA---------EDL-------------------RHEQEQSQQL--ERFKKQLESAVKDLQ 1810

  Fly  1673 KFSPEPLKAPLLKAVVKVPPLFQQALVMHHHIL----KYMGD----IARSNLPVNTDLIFQPA-- 1727
            : ..:..:|.::|...|.....:|.|......|    :..|:    :||::..|. :..||.|
 Worm  1811 E-RADAAEAAVMKGGAKAIQKAEQRLKAFQSDLETESRRAGEASKTLARADRKVR-EFEFQVAED 1873

  Fly  1728 ------LQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRA 1786
                  ||.  |.::|..:|..|......:|.:.......|....|   |:....|       ||
 Worm  1874 KKNYDKLQE--LVEKLTAKLKLQKKQLEEAEEQANSHLSKYRTVQL---SLETAEE-------RA 1926

  Fly  1787 DALADACLKRLK-RSLAQGQRK 1807
            |: |:.||.|:: |:.|..::|
 Worm  1927 DS-AEQCLVRIRSRTRANAEQK 1947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	268/704 (38%)
		IQ	765..785	CDD:197470	5/24 (21%)
		Atrophin-1	<820..>946	CDD:460830	41/169 (24%)
		MyTH4	1031..1239	CDD:470587	39/243 (16%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	24/114 (21%)
		B41	1248..1429	CDD:214604	41/188 (22%)
		PH-like	1454..1547	CDD:473070	14/109 (13%)
		MyTH4	1674..1819	CDD:214535	34/151 (23%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
myo-2	NP_510092.2	COG5022	27..1478	CDD:227355	412/1498 (28%)
		MYSc_class_II	95..782	CDD:276951	268/693 (39%)
		SMC_prok_B	1097..1936	CDD:274008	174/1006 (17%)