DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and hum-6

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_508420.1 Gene:hum-6 / 180539 WormBaseID:WBGene00002039 Length:2098 Species:Caenorhabditis elegans


Alignment Length:2233 Identity:875/2233 - (39%)
Similarity:1264/2233 - (56%) Gaps:269/2233 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVEDMI 73
            ||:::|::|..|  |.::|.|||::..:..:..|.||...:.|:.|...::.||.||.:.||||.
 Worm     6 KGDFIWIEPGKT--EGSIPIGARVIDQDHGRLKVIDDLGNEQWLSADRRVRLMHPTSVQGVEDMC 68

  Fly    74 TLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFA 138
            .|||..|..|||||..||.::|||.||||:|:|:|||..:.|||..||::|:.|.:.||||||||
 Worm    69 QLGDFHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGELPPHIFA 133

  Fly   139 ISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEAFGN 203
            |:|||:..::|.|:||.|:|||||||||||||||:||:||.|||:|||||||::||||::|||||
 Worm   134 IADNAYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISGQHSWIEQQVLEANPVLEAFGN 198

  Fly   204 AKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAE 268
            |||:||||||||||||::.|...|:|:||:|:||||||||||.||.:|||||||||:|||||..|
 Worm   199 AKTIRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIFYCLLAGLSREE 263

  Fly   269 RERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLG 333
            :..|:|  .:.:.|:||.||...|..||.||.|.|:||:||:||....:|:.||..|||::||:|
 Worm   264 KSELEL--GTAADYYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIFKLLASLLHIG 326

  Fly   334 NLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEG 398
            |:||......|:.:.::.|...|.|:|:||.:....|..|:|.:::....|.|.:.|:.:.|::.
 Worm   327 NIRFRQNTNDNMESVDVADPSTLVRIAKLLQLHEQNLLDAITTKSLVTREERVISRLNGQQAVDA 391

  Fly   399 RDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQ 463
            |||..|::|..:|:.||||:|:.|.|.......|||:|||||||||::|||||||||:|||.|||
 Worm   392 RDALAKAIYGKLFIHIVRRVNDAIYKPSQSRRTSIGILDIFGFENFESNSFEQLCINFANETLQQ 456

  Fly   464 FFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKL 528
            |||.|:|||||.||..|||||:||:|.|||..:|||..:|:|::|||||||.||||||:|:|.||
 Worm   457 FFVHHVFKMEQKEYDEEHINWRHIKFVDNQATVDLIAQRPLNILSLIDEESIFPKGTDKTMLLKL 521

  Fly   529 HVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIF 593
            |..||...:|::.|:.....||:.|:||.|.||..|||||||||||.||..|:..|...:|..:|
 Worm   522 HSTHGRNELYLQPKSELQRAFGVTHFAGNVFYNTRGFLEKNRDSFSADLSVLISSSKMPFLARLF 586

  Fly   594 PHEMPMDT-AKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYS 657
             .::..|| ::|:.|:..:||.||:.||..|:|.||:|||||||||.|.....|::|.:||||||
 Worm   587 -DDIEYDTSSRKKVTVGNQFRRSLEQLMSQLTQTHPFFIRCIKPNEMKRALVMDRDLVLRQLRYS 650

  Fly   658 GMMETARIRRAGYPIRHAYRAFVERYRLLVPPV-GPLEQCDCRKLARQICEVALPADSDRQYGKT 721
            |||||.:|||:||||||.|..||.|||:||..: ||:.:.|....|::||.:.|..::|.|.|||
 Worm   651 GMMETIKIRRSGYPIRHDYYPFVFRYRVLVSSIQGPVNRIDLHDAAKKICHMILGTNADYQLGKT 715

  Fly   722 KLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQV 786
            |:||:|:.|..||.:..:::....:.||:.:||.|.|:..::.|:|.:|:|..|||..||::|:.
 Worm   716 KVFLKDKHDLVLEQEYYRILKDKAIVIQKNVRRWLVRKDFEKQRQAAVTIQTAWRGFDQRKRYRQ 780

  Fly   787 MRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKL 851
            :..||.||.|.:.::||.:.:..:|...|:.||:.||.|||                        
 Worm   781 IISGFSRLQAVLRSRQLVSHYQTLRKTIIQFQAVCRGSLVR------------------------ 821

  Fly   852 AKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEA 916
                                   |:..|||.:.|                               
 Worm   822 -----------------------RQVGEKRKRGE------------------------------- 832

  Fly   917 PKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFL--- 978
             |||..:..::                  ||.::              :|.:::|..:|.||   
 Worm   833 -KAPLTEVSST------------------ASVIS--------------DSHEELVGHLFDFLPSD 864

  Fly   979 -------NDEPDAALRKLNNISSGDTIRL---PKSVPNNI---------DTSDFSYLKYAATYFG 1024
                   ||..|::.|       |...||   |...|.||         |.|.:.:.|||||:|.
 Worm   865 GKDSGNENDSADSSRR-------GSYSRLHTSPVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQ 922

  Fly  1025 GGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPT--LHVFDNENLMSDL 1087
            ..|||.|.:||||.:||.|..|..::|:...|.|||||||||.||....|  ..|:|...:|..|
 Worm   923 AQATATHVKKPLKTALLTHTEPSAQLAALTAWTTILRFMGDLADVKPGSTNGSEVYDKTPVMIKL 987

  Fly  1088 ASLLN------------TSDSY---------KPRLFVRQSQRRIPK------PLASGEKEAQEFY 1125
            .:.|.            .|..|         ..|..:..:.:|..|      ...|.:.....|.
 Worm   988 YATLGKKFSAHDLEEAMLSSEYGGAKTLKKGMGRKLISMTLKRKGKINGSDTSSISSDSVYSSFN 1052

  Fly  1126 QHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPS 1190
            ....|.|.:.|:|:|:|||.||::..|||||..|:||||..|||:.|.:|||:|||||:.||.||
 Worm  1053 AMLENKPMTSLDKLHYIIGLGILREDLRDEIYCQLCKQLSNNPSKLSAARGWILLSLCVGCFAPS 1117

  Fly  1191 KEFEPHLRSFMKQ-GTAQLQATPSLQ-RLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDG 1253
            :.|..:|..|::: |.|....:..:: ||.||.|||.|.||||..||.|.:.:.|:.|.:..|||
 Worm  1118 ERFIKYLFCFIRERGPAGTGYSKYIEDRLRRTQVNGTRHQPPSYVELQANKSQKPVVLAVTFMDG 1182

  Fly  1254 QQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQ---- 1314
            ..:.|..|:|:||.|...||.:.:|||::|||.|.::|..|:..||:|.:||:||||:|||    
 Worm  1183 SVKTLCADSATTAAELCKQLAEKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMDAISQCEQYAKE 1247

  Fly  1315 ---RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACF 1376
               ::.:|||:|:.|||:|:.|:||..||.:|.|||:|::.|:|.|||||..::::|.:||...:
 Worm  1248 QGRQERNAPWRLFFRKEIFSPWHDPRDDPVSTNLIYQQVIRGIKYGEYRCDKDEELAAICAQQYY 1312

  Fly  1377 VEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAK 1441
            ::.|..::.:|: :.:.:::|...::..|.|:|.|::.|...|.|....:       |.:|...|
 Worm  1313 IDEGTMDVNKLE-NNLPSYLPDFEMSGKEMALEKWTQTIMHQYRKKFTGR-------LPSQIEVK 1369

  Fly  1442 EDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKVH 1506
            |::...|...||:..||.:|.::..||.|..:|:::.:|..|::::|:.|.|:....|.|:...:
 Worm  1370 ENVVSVAKTKWPLLFSRFYEALKFAGPPLPKNEVIIAVNWTGVYVVDDREHVMLEFSFPEISTAY 1434

  Fly  1507 V-----ESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCL 1566
            .     .:.|...|.|.....:..|..:|.|...:|...|:.|::||.|.||:......:..:.|
 Worm  1435 YGKGKRSTTDTCTVRTVVGDEYTFQSPNADDITNLIVMFLEGLKKRSRYLVAIKSQKGDEKNNFL 1499

  Fly  1567 VLNPGDLIEFEAGVTGAQLM------AGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQD 1625
            ....|||:......||..|:      ..|::.|..|.:.       |.||.||.||.|||:....
 Worm  1500 EFEKGDLLILVNEFTGNTLLTESVVKGENSRTCLFGLIR-------AENVYVLPTLVKPSKNTLQ 1557

  Fly  1626 ILREGRFQEPPKPTPRA--NYSRRRQ----------HNISQLAESHFREPLDSDKAPLS------ 1672
            |.        ||....:  .::..:|          :.:...||.:|...:....:.:|      
 Worm  1558 IF--------PKDMDLSLDLFNNNKQVTVVDYNAEPYTLENFAEDNFNSQVKRVGSQISLMTLRK 1614

  Fly  1673 --------KFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGD--IARSNLPVN-TDLIFQP 1726
                    :||.|.:..||||.:.......:.|:.:...|:|||||  ..||.|..: ||.||:.
 Worm  1615 KESQIECWRFSREHIDQPLLKKLNGREDACRGAIEIFAAIMKYMGDEPSKRSRLGTHLTDHIFKL 1679

  Fly  1727 ALQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALAD 1791
            .:....|.|||||||:|||:.|||..||:|||:||::||||.|||..:.:|:...|:.|...:|.
 Worm  1680 PISMEALRDELYCQLVKQLTLNPSIMSEERGWELLWMATGLFAPSAALAKEISHFLKSRPHPIAL 1744

  Fly  1792 ACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQ 1856
            .|..|:::....|.||..|||:|||.||.:...|:||::|||:|.||.|::|.||..:....|..
 Worm  1745 DCQNRMQKLAKGGSRKYPPHLVEVEAIQHKTTQIFHKVFFPDNTDEAIEVDSATRARDFCHKIGY 1809

  Fly  1857 RLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWL------RQQRTIRSISDGQYQLHFM 1915
            ||.|||..|:|:|:|..|:|.|:||.||.||::..|..|:      ::..|:..|:   ||::||
 Worm  1810 RLGLKSSDGFSLFVKIKDKVLAVPESEFFFDYVRSLSDWVHTNHATQKDATMIPIN---YQVYFM 1871

  Fly  1916 RKLWLNNHPGEDLNGDMIFSYPQELHKYLKGYYPIDCEQASRLAILVYSA----DHDVSLQRLPE 1976
            ||||.|...|.|...|:||.|.||..|||.||:.........||.|:..:    ..:..|.::|:
 Worm  1872 RKLWYNFVAGADPQADIIFHYHQESQKYLLGYHKTTKNDVIELAALILRSMTKDGKNAPLAQIPQ 1936

  Fly  1977 VLTRLIPEDLIPLQTVAEWRQQILPKVHR-DHLTEDHAKILFLQELSHFACFGSTFFVVKQQNDD 2040
            :|..:||:|.:.:.:.:|||:.|.....| :||..|.|||.||..:..:..|||.||.|.|.:|.
 Worm  1937 LLDEIIPKDSLKMYSASEWRKTISNAYARIEHLKSDQAKIEFLNYICRWPTFGSAFFPVSQYSDL 2001

  Fly  2041 ALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIWSSGKNHFHIRFGNMIGAS---KLLCSTT 2102
            .||:.||:|||.||.::....||.:|..|.::.:..|:||..:|::..|||:..:   |||..||
 Worm  2002 NLPDRLLLAINQTGVNIYHLDTKNLLVQYPFNVICNWTSGNTYFNMTVGNMLKGNEGKKLLLDTT 2066

  Fly  2103 QGYKMDDLLASYVKYF----NEH 2121
            .||||||||.||:...    |.|
 Worm  2067 VGYKMDDLLTSYISLLISNQNNH 2089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 373/676 (55%)
MYSc_Myo7 81..726 CDD:276832 357/646 (55%)
IQ 765..785 CDD:197470 9/19 (47%)
DUF4355 827..>887 CDD:290964 6/59 (10%)
MyTH4 1031..1239 CDD:295320 91/238 (38%)
B41 1248..1429 CDD:214604 70/187 (37%)
FERM_N 1248..>1288 CDD:286467 17/39 (44%)
FERM_B-lobe 1342..1429 CDD:271216 25/86 (29%)
PH-like 1454..1547 CDD:302622 23/97 (24%)
MyTH4 1674..1819 CDD:214535 64/147 (44%)
B41 1827..2032 CDD:214604 82/215 (38%)
FERM_N 1829..>1877 CDD:286467 21/47 (45%)
FERM_M 1936..2032 CDD:278785 33/100 (33%)
FERM_C2_MyoVII 2028..2121 CDD:270020 43/99 (43%)
hum-6NP_508420.1 MYSc 57..731 CDD:214580 373/676 (55%)
MYSc_Myo7 76..720 CDD:276832 357/646 (55%)
IQ 757..779 CDD:197470 9/21 (43%)
MyTH4 929..1168 CDD:214535 91/238 (38%)
B41 1174..1388 CDD:214604 80/221 (36%)
FERM_B-lobe 1278..1378 CDD:271216 30/107 (28%)
FERM_C1_MyoVII 1382..1480 CDD:270019 23/97 (24%)
SH3 1481..1544 CDD:302595 17/69 (25%)
MyTH4 1624..1772 CDD:214535 64/147 (44%)
B41 1779..1993 CDD:214604 82/216 (38%)
FERM_B-lobe 1890..1985 CDD:271216 31/94 (33%)
FERM_C2_MyoVII 1989..2087 CDD:270020 42/97 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160165728
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1958
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D21221at33208
OrthoFinder 1 1.000 - - FOG0001409
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.660

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