DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo28B1 and Myo7b

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_115770.2 Gene:Myo7b / 17922 MGIID:107709 Length:2113 Species:Mus musculus


Alignment Length:2235 Identity:851/2235 - (38%)
Similarity:1245/2235 - (55%) Gaps:272/2235 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV--LKAMHITSQEDVE 70
            |.|::||:.|. ::|:..|..|..:..|:..:||:.||..|:.||.|.|:  |:.||..|.:.|:
Mouse     5 RLGDHVWLDPP-SSSKTGVAIGGIVKETKLGKTLIEDDEGKEHWVHAEDLSTLRPMHPNSAQGVD 68

  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPH 135
            |||.||||.|..::.||..||.:..|||||||:|||:||:|:||:||..::|:|.::.:.|||||
Mouse    69 DMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPH 133

  Fly   136 IFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEA 200
            ||||:::.:..:::.|.:||.:|||||||||||:||||||:||.:||:|||||||::|||||:||
Mouse   134 IFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSGQHSWIEQQVLEANPILEA 198

  Fly   201 FGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLS 265
            ||||||:||||||||||||:|.|...|.|:||.|:.:||||||:..|:.:|||||||||||.|:|
Mouse   199 FGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLMGMS 263

  Fly   266 TAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAIL 330
            ..|::.|.|  ..||:||||..|.|.:..|..||||:|.:|:|||:|.|...|.|.|..||||||
Mouse   264 PEEKQMLSL--GMPSEYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAIL 326

  Fly   331 HLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAA 395
            ||||:.|.|....||.::::.:||......:||.:...||...|.:.||.|.||.|:..::...|
Mouse   327 HLGNVGFMAAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQA 391

  Fly   396 IEGRDAFVKSLYDGIFVRIVRRINETI-NKQVDQPMN---SIGVLDIFGFENFDNNSFEQLCINY 456
            .:.||||||.:|..:|..||::||..| ..|...|.|   :||:|||||||||.||||||||||:
Mouse   392 TDRRDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCINF 456

  Fly   457 ANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTD 521
            |||:||||||.|:|.|||:||.:|:|.|.:|.:.|||.|||::.:|||:::||:||||:||:|||
Mouse   457 ANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEESRFPQGTD 521

  Fly   522 QTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTN 586
            .|:|:||:..|.|...::..::...:.|||.|:||.|.|...||||||||..|.|:..|:..|.|
Mouse   522 VTMLQKLNSIHANNKSFLSPRSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSKN 586

  Fly   587 KYLVDIFPHEMPM---------------------DTAKKQPTLCVKFRNSLDMLMRTLSQAHPYF 630
            |:|.:||..:...                     |:.|:..||..:|:.|||.|||.|:...|||
Mouse   587 KFLKEIFNVDSSQTKLGHGTICQVKAGSQLFKSSDSIKRPVTLASQFKQSLDQLMRILTNCQPYF 651

  Fly   631 IRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLE- 694
            :|||||||||:|..||:|||::||||||||||..||::|:|||:.:..|.:|:|:|:|....:: 
Mouse   652 VRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERMQF 716

  Fly   695 QCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRR 759
            |...|::...|.::.|..|.|.:.||||:||:|..|..||::|||.:..:.:.|||.:|...:|:
Mouse   717 QNKPRQMTLHIADLCLGTDKDWKVGKTKIFLKDHQDTVLEIRRSQALDGAAIRIQRVLRGHKYRK 781

  Fly   760 YMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGY 824
            ...|.|.|.:|:|..|||..||:.::::..||.||.|...:..|..:|..:|.|.::|||..|||
Mouse   782 EFLRQRRAAVTLQAGWRGYSQRKNFKLILVGFERLQAIARSHLLMRQFQAMRQRIVQLQARCRGY 846

  Fly   825 LVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLK 889
            |||:..|.|                     :.|..::                            
Mouse   847 LVRQQVQAK---------------------RRAVVII---------------------------- 862

  Fly   890 AEAAARNALAMAAVQQKRRTKP--VKQEAPKAPTL---QARNSLPPPPTTLIVAAPLPTRPASAV 949
             :|.||..:...:..|::.|.|  :..:.|||...   :.|.|:                     
Mouse   863 -QAHARGMVVRKSYWQQKSTGPQVILAKEPKAQVAVHERKRKSI--------------------- 905

  Fly   950 TRINTIPESPGTIDVESSKQMVDDVFRFLN--------------DEPDAALRKLNNISSGDTIRL 1000
                        .|..:...||:.||.||.              ::.:...:||:.:.. ||:.:
Mouse   906 ------------YDTVTDTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQKLHEVDL-DTVPM 957

  Fly  1001 PKSVPNNIDT-SDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMG 1064
            .......:|: :::::.|:|.|||...|:..|.:|||:..||.||:..|..|:..:|:.||||||
Mouse   958 MAMPEEEVDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALDVWIIILRFMG 1022

  Fly  1065 DLPDVV---------SSPTLHVFD--------NENLMSDLASLLNTSDSYKPRLFVRQSQRRIPK 1112
            |||:.|         ||....:.|        ..|..|.:||.||..:                 
Mouse  1023 DLPEPVVYGRNSLTGSSVMRQIHDKLGKDSVTQHNRSSQVASQLNFGE----------------- 1070

  Fly  1113 PLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGW 1177
                   ||.:|.....:.|.|:|||:|||:|:.|::..|||||..||||||..|...||.:|||
Mouse  1071 -------EAFKFDGPISDRPMSNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGW 1128

  Fly  1178 LLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPS-----LQRLERTLVNGPRCQPPSLFELHA 1237
            :||||||.|||||:.|..:|.:|:.||      .||     .:||:||..||.|.:||:..||.|
Mouse  1129 ILLSLCLGCFPPSERFMKYLLNFISQG------PPSYGPFCAERLQRTFANGVRAEPPTWLELQA 1187

  Fly  1238 IRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQ 1302
            ::.:..:.:.:.|..|:...:.||:|||:||....:.|..||.|..||.|.:::..|...||:|.
Mouse  1188 VKSKKHIPIQVILATGRSLTISVDSASTSREICQHVAQKQGLRDNLGFSLQVAVYDKFWSLGSGC 1252

  Fly  1303 EHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYR 1360
            :|::||:::|||       .|..|||::|.|||.|..|:|...||.:|:|||.|:|.|:..|||.
Mouse  1253 DHLMDAVAQCEQLARERGESQRQAPWRIYFRKEFFTPWHDSQEDPVSTELIYHQVLRGVWSGEYN 1317

  Fly  1361 CRSEKDIAMVCALACFVEYG----PGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEK 1421
            ...|:::..:.|..|:|:.|    ...:..|.||    .|||.|..  .::.|.|:.|:.|.:.|
Mouse  1318 FEKEEELVELLARHCYVQLGATVKSNAVQELLPS----CVPSKLYR--TKSPEKWASLVTAAHAK 1376

  Fly  1422 SSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFL 1486
            :.|.:.:...|.:      :|.....|.|.||:..||||||....||:|...:|:|.||..|::.
Mouse  1377 AQYTQSKATPLAV------REQTVEAARLLWPLLFSRLFEVTTLSGPRLPKTQLVLAINWKGMYF 1435

  Fly  1487 IDETEQVLASCCFSEVLKVHVESD----DKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQR 1547
            :|:.|:.|....|:||:.:....|    .||.:.|.|.....:..||...| |::...|..|::|
Mouse  1436 LDQKERTLLGLSFAEVMGLVANRDAPGGKKLLLATLQEEYEFVSPSSVAIA-EMVALFLGGLKER 1499

  Fly  1548 SSYGVALDPVVEGDLEDCLVLNPGDLIEF--EAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNV 1610
            |.:.:||......|....|....|||:..  :.|:..::..|....|     ..|:.|......:
Mouse  1500 SVFAMALQDRRATDDITLLPFKKGDLLILTKKQGLLASENWALGQND-----RTGKTGLVPTACL 1559

  Fly  1611 RVLATLTKPSEKLQDIL-----------REGRFQEPP-------KPTPRANYSRR-----RQHNI 1652
            ..:.::||||.:|..:|           :|.|..|||       .|.....:|.:     .:..|
Mouse  1560 YTIPSVTKPSTQLLSLLAMSPEKRKLAAQEVRALEPPLEDQLTESPYTLEEFSYQFFRAPEKETI 1624

  Fly  1653 SQLAESHFREPLDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDI----AR 1713
            |:.|     .|:...:..|..:|||||:.||||:|.....|...|..:...||||.||.    :.
Mouse  1625 SRAA-----MPMARSRGHLWAYSPEPLRQPLLKSVHDKAKLRDAACQIFLAILKYTGDYPSRQSW 1684

  Fly  1714 SNLPVNTDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAP--SVLVMR 1776
            .:|.: ||.:|..|||.|.|.||||||::|||:.|....||:|.|.||:|.|||..|  ::|...
Mouse  1685 HSLEL-TDQMFSLALQDPALQDELYCQILKQLTHNSIRFSEERAWQLLWLCTGLFPPGKTLLPHA 1748

  Fly  1777 ELIILLRMRADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEI 1841
            :..|..|.:.....| |.:||.|.|..|.||:.||.:||:..:|....::|::|.|:||.::.|:
Mouse  1749 QKFIDSRKKKPLALD-CSRRLHRVLRVGPRKQPPHDVEVKAAEQNVSKLHHEVYLPNDTSKSMEV 1812

  Fly  1842 ESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSIS 1906
            .|.:|..:|...|..||:|.|..|.|:|:|..|:|.::.|.:|.||.:.|:..|:::.|..:   
Mouse  1813 GSSSRVRDLCEGIGTRLQLASWDGCSLFIKITDKVISLKEGDFFFDSLRQVSDWVKKNRPQK--- 1874

  Fly  1907 DG-----QYQLHFMRKLWLNNHPGEDLNGDMIFSYPQELHKYLKGYYPIDCEQASRLAILV---- 1962
            :|     .||:.||||||||..||:|:|.|.|..|.|||.|||:|::....|.|..|..|:    
Mouse  1875 EGASVTLPYQVFFMRKLWLNVTPGKDVNADTILHYHQELPKYLRGFHKCSREDAIHLGGLICKIQ 1939

  Fly  1963 YSADHDVSLQRLPEVLTRLIPEDLIPLQTVAEWRQQILPKVHRD-HLTEDHAKILFLQELSHFAC 2026
            :.:|.. .|..:.:||..|:|::|..|.:..||::.:|.:..:: ..|...||:.||:.:..:..
Mouse  1940 FGSDSS-QLASVSKVLKELVPQNLTRLMSSEEWKKSLLLECDKNKRKTVAEAKVEFLKYMYRWPT 2003

  Fly  2027 FGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIWSSGKNHFHIRFGNM 2091
            |||.||.|||.::.:.|:.||||||..|..::.|.|||:|.:|.::::..||||..:||:..|::
Mouse  2004 FGSAFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTKELLNTYPFTKISSWSSGNTYFHMALGSL 2068

  Fly  2092 IGASKLLCSTTQGYKMDDLLASYVK 2116
            ...|:|||.|:.||||||||.|||:
Mouse  2069 GQGSRLLCETSLGYKMDDLLTSYVQ 2093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 355/700 (51%)
MYSc_Myo7 81..726 CDD:276832 339/670 (51%)
IQ 765..785 CDD:197470 9/19 (47%)
DUF4355 827..>887 CDD:290964 4/59 (7%)
MyTH4 1031..1239 CDD:295320 90/229 (39%)
B41 1248..1429 CDD:214604 67/191 (35%)
FERM_N 1248..>1288 CDD:286467 15/39 (38%)
FERM_B-lobe 1342..1429 CDD:271216 28/90 (31%)
PH-like 1454..1547 CDD:302622 31/96 (32%)
MyTH4 1674..1819 CDD:214535 64/150 (43%)
B41 1827..2032 CDD:214604 75/214 (35%)
FERM_N 1829..>1877 CDD:286467 18/47 (38%)
FERM_M 1936..2032 CDD:278785 31/100 (31%)
FERM_C2_MyoVII 2028..2121 CDD:270020 44/89 (49%)
Myo7bNP_115770.2 MYSc 60..759 CDD:214580 355/700 (51%)
MYSc_Myo7 79..748 CDD:276832 339/670 (51%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 637..659 14/21 (67%)
IQ 785..807 CDD:197470 10/21 (48%)
Mediates interaction with ANKS4B. /evidence=ECO:0000269|PubMed:26812017 962..1578 221/663 (33%)
MyTH4 989..1189 CDD:214535 90/229 (39%)
B41 1196..1409 CDD:214604 75/224 (33%)
FERM_B-lobe 1299..1400 CDD:271216 31/112 (28%)
FERM_C1_MyoVII 1403..1499 CDD:270019 31/96 (32%)
Mediates interaction with CDHR2, CDHR5 and USH1C. /evidence=ECO:0000250|UniProtKB:Q6PIF6 1497..2113 214/613 (35%)
SH3 1500..1560 CDD:302595 13/64 (20%)
MyTH4 1641..1788 CDD:214535 64/148 (43%)
B41 1797..2009 CDD:214604 75/215 (35%)
FERM_M 1907..2009 CDD:278785 31/102 (30%)
FERM_C2_MyoVII 2005..2100 CDD:270020 44/89 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848172
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1958
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D21221at33208
OrthoFinder 1 1.000 - - FOG0001409
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.660

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