DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and Myh9

DIOPT Version :10

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_071855.2 Gene:Myh9 / 17886 MGIID:107717 Length:1960 Species:Mus musculus


Alignment Length:2125 Identity:532/2125 - (25%)
Similarity:875/2125 - (41%) Gaps:507/2125 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 AGYSPRKGEYVWV-------KPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKA 60
            |.::.:|  .|||       :|.:...|         |..|....||  :..|:..|...|:.| 
Mouse    24 ADWAAKK--LVWVPSSKNGFEPASLKEE---------VGEEAIVELV--ENGKKVKVNKDDIQK- 74

  Fly    61 MHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYR 125
            |:......||||..|..|.|.::|.||:.||...|||||:|...|.||||:.||||:...:::|:
Mouse    75 MNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYK 139

  Fly   126 NKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKH------ 184
            .|...|:||||:||:|.|::.:.:.:|:|.::.:|||||||||:||.::||||.::..|      
Mouse   140 GKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQ 204

  Fly   185 SWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSR 249
            ..:|:|:::||||:|||||||||:|||||||||:|.|.|...|.|.||.|:.|||||||.:.|::
Mouse   205 GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAK 269

  Fly   250 DERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSF 314
            :||.:||||.:|:|  ..|..:..|..:..::|.:|:.|. .|:||:.|...|.:...||:::..
Mouse   270 EERTFHIFYYLLSG--AGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGI 331

  Fly   315 KPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTI 379
            ..:|...:|.:::.:|.|||:.|  .:..|...|.:.|....|:|:.||||.::.....:....|
Mouse   332 PEDEQMGLLRVISGVLQLGNIAF--KKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRI 394

  Fly   380 FVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENF 444
            .|..::|..:.:||.|....:|..|:.|:.:|..:|.|||:.::|...|..:.||:|||.|||.|
Mouse   395 KVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIF 459

  Fly   445 DNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMK--PMNL 506
            |.||||||||||.||.|||.|...:|.:||:|||.|.|.|..|:| .|.|..:|||...  |..:
Mouse   460 DLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGI 524

  Fly   507 MSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSL-FGIRHYAGVVMYNPLGFLEKNR 570
            ::|:|||..|||.||::.:||:..:.|....:.|.|..:... |.|.||||.|.|....:|.||.
Mouse   525 LALLDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNM 589

  Fly   571 DSFSGDLRTLVQRSTNKYLVDIFP--------------HEMPMDTAKKQ-----PTLCVKFRNSL 616
            |..:.::.||:.:|::|::.:::.              .|..:..|.|.     .|:...::..|
Mouse   590 DPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQL 654

  Fly   617 DMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVE 681
            ..||.||...:|.|:|||.||..|:....|..|.:.|||.:|::|..||.|.|:|.|..::.|.:
Mouse   655 AKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQ 719

  Fly   682 RYRLLVP---PVGPLEQCDCRKLARQICEV---ALPADSD-RQYGKTKLFLRDEDDASLELQRSQ 739
            ||.:|.|   |.|.::       .:|.|.:   ||..||: .:.|::|:|.|....|.||.:|..
Mouse   720 RYEILTPNSIPKGFMD-------GKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDL 777

  Fly   740 LMLKSIVTIQRGIRRVLFRR-YMKRYRE--AIITVQR------------YWR------------- 776
            .:...|:..|...|..|.|: :.||.::  |:..:||            :||             
Mouse   778 KITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLRLRNWQWWRLFTKVKPLLNSIR 842

  Fly   777 ---------------------------------GRLQRRKYQVMRQGFHRLGACIAAQQLTTKFT 808
                                             .:|...|.|:..|.......|..|::|..:.|
Mouse   843 HEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLT 907

  Fly   809 M--------------------VRCRTI-------------------------------------K 816
            .                    .||:.:                                     |
Mouse   908 AKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAK 972

  Fly   817 LQALSRGYLVRKD------FQKKLLERR----KQNQLKKEELLK-LAKMKEAEELLRLQQLKEQK 870
            |:.|....::.:|      .:|||||.|    ..|.:::||..| |||:|...|.: :..|:|:.
Mouse   973 LKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAM-ITDLEERL 1036

  Fly   871 EREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTL 935
            .||::::||   .|:.|.|.|..:.:.....|..|.:..:...|.|.|...|||           
Mouse  1037 RREEKQRQE---LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA----------- 1087

  Fly   936 IVAAPLPTRPASAVTRINTIPESPGTI-----DVES---SKQMVDDVFRFLNDEPDAALRK---- 988
             ..|.:....|.....:..|.|....|     |:||   |:...:...|.|.:|.:|...:    
Mouse  1088 -ALARVEEEAAQKNMALKKIRELETQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151

  Fly   989 LNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERK----PLKKSLLKHEHPIDE 1049
            |::.::...:|..:.       .:.|.||         .|.:.|.|    .:::...||...::|
Mouse  1152 LDSTAAQQELRSKRE-------QEVSILK---------KTLEDEAKTHEAQIQEMRQKHSQAVEE 1200

  Fly  1050 MA-----SKAIWLTILRFMGDLPDVVSSPTLHVFDNE--NLMSDLASLL-NTSDSYKPRLFVRQS 1106
            :|     :|.:..|:.:         :..||   :||  .|.:::.:|| ...||...|..|...
Mouse  1201 LADQLEQTKRVKATLEK---------AKQTL---ENERGELANEVKALLQGKGDSEHKRKKVEAQ 1253

  Fly  1107 QRRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNS--LRD----EILAQICKQLY 1165
            .:.:....:.||:...|.......:.. .|:.:..::.....|:|  .:|    |...|..::|.
Mouse  1254 LQELQVKFSEGERVRTELADKVTKLQV-ELDSVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL 1317

  Fly  1166 LNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQR-----------LER 1219
            ...:|...|     ||..|      |:.|....||.:|...:.:|..:|::           :::
Mouse  1318 QEENRQKLS-----LSTKL------KQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKK 1371

  Fly  1220 TLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFG 1284
            .:.:|..|                    :...:..:||||.|....::....::.....|..| .
Mouse  1372 KMEDGVGC--------------------LETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKT-K 1415

  Fly  1285 FGLVMSLNGKLMPLGAGQEHVLDAISECEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQ 1349
            ..|...|:..|:.|    :|...::|..|::|                       .|..||:.::
Mouse  1416 TRLQQELDDLLVDL----DHQRQSVSNLEKKQ-----------------------KKFDQLLAEE 1453

  Fly  1350 ILNGLKCGEYRCRSE--------KDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGER 1406
            .....|..|.|.|:|        |.:::..||...:|. ..|:.||.....|..  .||::..:.
Mouse  1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ-KAELERLNKQFRTEM--EDLMSSKDD 1515

  Fly  1407 AIENWSRLIAATYEKSSYVKEEQNDLL------LEAQKRAKEDICLFAHLSWPMRHSRLFEVVRK 1465
            ..::...|     |||....|:|.:.:      ||.:.:|.||             ::|...|..
Mouse  1516 VGKSVHEL-----EKSKRALEQQVEEMKTQLEELEDELQATED-------------AKLRLEVNL 1562

  Fly  1466 EGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSA 1530
            :..|.|.:..:.|        .||..:........:|.::..|.:|:                  
Mouse  1563 QAMKAQFERDLQG--------RDEQSEEKKKQLVRQVREMEAELEDE------------------ 1601

  Fly  1531 QDANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGA---------QLM 1586
                          |::.|..:|....:|.||:|           .||.:..|         ||.
Mouse  1602 --------------RKQRSMAMAARKKLEMDLKD-----------LEAHIDTANKNREEAIKQLR 1641

  Fly  1587 AGNAQ--DCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDILREG-RFQEPPKPTPRANYSRRR 1648
            ...||  ||.|     :.....|....:||...:..:||:.:..|. :.||......||  .|:.
Mouse  1642 KLQAQMKDCMR-----ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA--KRQA 1699

  Fly  1649 QHNISQLAESHFREPLDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGD-IA 1712
            |....:||:....   .|.|..|:......|:|.:.:        .::.|.......:.:.| :.
Mouse  1700 QQERDELADEIAN---SSGKGALALEEKRRLEARIAQ--------LEEELEEEQGNTELINDRLK 1753

  Fly  1713 RSNL---PVNTDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLV 1774
            ::||   .:||||..:.:  |            .|.::|...:.|::..:|         .:.|.
Mouse  1754 KANLQIDQINTDLNLERS--H------------AQKNENARQQLERQNKEL---------KAKLQ 1795

  Fly  1775 MRELIILLRMRAD-ALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEA 1838
            ..|..:..:.:|. |..:|.:.:|:..|....:::.....:|...:::...:            .
Mouse  1796 EMESAVKSKYKASIAALEAKIAQLEEQLDNETKERQAASKQVRRTEKKLKDV------------L 1848

  Fly  1839 FEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMPEEE 1883
            .::|...|.||...|.|.:...:        ||...|.....|||
Mouse  1849 LQVEDERRNAEQFKDQADKASTR--------LKQLKRQLEEAEEE 1885

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc_Myo7 81..726 CDD:276832 260/680 (38%)
IQ 765..785 CDD:197470 7/79 (9%)
Atrophin-1 <820..>946 CDD:460830 36/136 (26%)
MyTH4 1031..1239 CDD:470587 43/236 (18%)
FERM1_F1_Myosin-VII 1243..1334 CDD:340612 15/90 (17%)
B41 1248..1429 CDD:214604 38/188 (20%)
PH-like 1454..1547 CDD:473070 11/92 (12%)
MyTH4 1674..1819 CDD:214535 23/149 (15%)
FERM2_F1_Myosin-VII 1825..1919 CDD:340613 12/59 (20%)
B41 1827..2032 CDD:214604 12/57 (21%)
FERM_C2_MyoVII 2028..2121 CDD:270020
Myh9NP_071855.2 Mediates interaction with LIMCH1. /evidence=ECO:0000250|UniProtKB:P35579 2..838 300/839 (36%)
Myosin_N 27..72 CDD:460670 12/57 (21%)
Motor_domain 95..764 CDD:473979 260/680 (38%)
Actin-binding 654..676 11/21 (52%)
Myosin_tail_1 842..1921 CDD:460256 232/1281 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1167 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1352 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1768..1788 4/33 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1908 4/9 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1939..1960
Blue background indicates that the domain is not in the aligned region.

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