Protein Alignment Myo28B1 and Myh3

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001093105.1
• Gene: Myh3 / 17883
• MGIID: 1339709
• Length: 1940
• Species: Mus musculus
• Alignment Length: 2100
• Identity: 541/2100 - (25%)
• Similarity: 855/2100 - (40%)
• Gaps: 515/2100 - (24%)

  Fly     9 KGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVEDMI 73
            |.|||..|.:::..      |...|.||.::|||         |...||. ||:....:.:|||.
Mouse    44 KEEYVKGKIKSSQD------GKVTVETEDSRTLV---------VKPEDVY-AMNPPKFDKIEDMA 92

  Fly    74 TLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFA 138
            .|..|.|..:|.||::||...:||||:|...|.:|||:.||:|....:..||.|...|.|||||:
Mouse    93 MLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEAPPHIFS 157

  Fly   139 ISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAI-----------SGKHSWIEQQII 192
            |||||:|.:...:|||.::|:||||||||.:||.::||.|.|           |.....:|.|||
Mouse   158 ISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQII 222

  Fly   193 EANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIF 257
            .|||::|||||||||||||||||||:|.|.|...|.:..|.|:.|||||||:.||.:.||:||||
Mouse   223 SANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIF 287

  Fly   258 YCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSI 322
            |.:|:. ...|...|.|...:|..|.:::||. ..:....||::.....:|:.:|.|.|||...:
Mouse   288 YQILSN-KKPELIELLLITTNPYDYPFISQGE-ILVASIDDAEELLATDSAIDILGFTPEEKSGL 350

  Fly   323 LSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVT 387
            ..|..|::|.||::|...:  ....||.|.|....:.|.|:|:..|.|..||....:.|..|:||
Mouse   351 YKLTGAVMHYGNMKFKQKQ--REEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVT 413

  Fly   388 TSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQL 452
            ...:.:......:|..||:|:.:|:.:|.|||:.::.::.: .:.||||||.|||.|:.||.|||
Mouse   414 KGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPR-QHFIGVLDIAGFEIFEYNSLEQL 477

  Fly   453 CINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMKPMNLMSLIDEESKF 516
            |||:.||.|||||..|:|.:||:||:.|.|.|..|:| .|....::|| .|||.:.|:::||..|
Mouse   478 CINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELI-EKPMGIFSILEEECMF 541

  Fly   517 PKGTDQTLLEKLHVQHGNRS------IYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSG 575
            ||.||.:...||:.||..:|      ..||||.  .:.|.:.||||.|.|:..|:||||:|..:.
Mouse   542 PKATDTSFKNKLYDQHLGKSNNFQKPKVVKGKA--EAHFSLVHYAGTVDYSVSGWLEKNKDPLNE 604

  Fly   576 DLRTLVQRSTNKYLVDIFPHEMPMD-------TAKKQ----PTLCVKFRNSLDMLMRTLSQAHPY 629
            .:..|.|:|:|:.|..::......|       .|||:    .|:...||.:|:.||..|...||:
Mouse   605 TVVGLYQKSSNRLLAHLYATFATTDADGGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPH 669

  Fly   630 FIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLE 694
            |:|||.|||.|.|...:..|.:.|||.:|::|..||.|.|:|.|..|..|.:|||:|.....|..
Mouse   670 FVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEG 734

  Fly   695 Q-CDCRKLARQICEVALPA-DSDR---QYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQ---RG 751
            | .|.:|    .||..|.: |.|.   ::|.||:|.:.....:||..|.:.:.|.|...|   ||
Mouse   735 QFIDSKK----ACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRG 795

  Fly   752 -IRRVLFRRYMKRYREAIITVQ---------RYW-------------RGRLQRRKYQVMRQGFHR 793
             :.||.|::.|:| ||:|..:|         ::|             :.....::...|::.|.:
Mouse   796 FLMRVEFQKMMQR-RESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQK 859

  Fly   794 LGACIAAQQLTTK------FTMVRCRT---IKLQALSRG---------YLVRKDFQ-----KKLL 835
            ....:|..:...|      .|:|:.:.   :::||.|..         .|::..||     |::.
Mouse   860 TKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVT 924

  Fly   836 ERRKQ-------------------NQLKKE------ELLKLAKMKEA---------EELLRLQQL 866
            ||.:.                   ::|||:      .|.|:.|.|.|         |||..|.:.
Mouse   925 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELAGLDET 989

  Fly   867 KEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPP 931
            ..:..||::..||...|....|:||....|:|:      |.::|..:|......:|:....|
Mouse   990 IAKLTREKKALQEAHQQTLDDLQAEEDKVNSLS------KLKSKLEQQVDDLESSLEQEKKL--- 1045

  Fly   932 PTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDD-----VFRF------LNDEPDAA 985
                  ...|..........:....||  .:|:|:.||.:|:     .|.:      :.||...:
Mouse  1046 ------RVDLERNKRKLEGDLKLAQES--ILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLS 1102

  Fly   986 L---RKLNNISS-----GDTIRLPKSVPNNIDTSDFSY------LKYAATYFGGGATAQHE---- 1032
            |   :|:..:.:     .:.|...::.....:.....|      |.......||..:.|.|
Mouse  1103 LQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKK 1167

  Fly  1033 --------RKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLAS 1089
                    |:.|:::.|:||..:..:..|                          :.:..::||.
Mouse  1168 REAEFLKLRRDLEEATLQHEATVATLRKK--------------------------HADSAAELAE 1206

  Fly  1090 LLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTS---------HLEKIHFIIGH 1145
            .::.....|.:|                |||..||.....::.:|         :||||...:..
Mouse  1207 QIDNLQRVKQKL----------------EKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLED 1255

  Fly  1146 GIIKNSLRDEILAQICKQLYLNPSRSSYSRGWL------------LLSLCLSCFPPSKEFEPHLR 1198
            .:.:...::|.:.:...:|....||.....|.|            .||.....|  :::.|...|
Mouse  1256 QLSEARGKNEEMQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAF--TQQIEELKR 1318

  Fly  1199 SFMKQGTAQLQATPSLQ---------------------RLERTL--VNGPRCQPPSLFELHAIRG 1240
            ...::..|:.....:||                     .|:|.|  .|....|..:.:|..||:.
Mouse  1319 QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR 1383

  Fly  1241 RHPL-----RLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGA 1300
            ...|     :|...|.|.::   ||       ||||..|..:..|.       ..|.|::..|..
Mouse  1384 TEELEEAKKKLAQRLQDSEE---QV-------EAVNAKCASLEKTK-------QRLQGEVEDLMV 1431

  Fly  1301 GQEHV--LDAISECEQRQLD---APWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYR 1360
            ..|..  |.|..:.:||..|   |.||                               .||.|.:
Mouse  1432 DVERANSLAAALDKKQRNFDKVLAEWK-------------------------------TKCEESQ 1465

  Fly  1361 CRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYV 1425
            ...|..:....:|:.       |:.:||.:...|.   |.|...:|..:|..:.||...|:.:
Mouse  1466 AELEAALKESRSLST-------ELFKLKNAYEEAL---DQLETVKRENKNLEQEIADLTEQIA-- 1518

  Fly  1426 KEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDET 1490
              |....:.|.:|..|:                         .:|:..::.:.:..|...|..|.
Mouse  1519 --ENGKSIHELEKSRKQ-------------------------MELEKADIQMALEEAEAALEHEE 1556

  Fly  1491 EQVL-----ASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSY 1550
            .::|     .:...||:.:...|.|:::..:...:...|.....|.||         .:|.|:.
Mouse  1557 AKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDA---------EVRSRNE- 1611

  Fly  1551 GVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLAT 1615
            .:.|...:||||.           |.|..::.|...|.......|. |.||
Mouse  1612 AIRLKKKMEGDLN-----------EIEIQLSHANRQAAETIKHLRS-VQGQ-------------- 1650

  Fly  1616 LTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAPLSKFSPEPLK 1680
            |......|.|.||.   ||..|               .|||       :...:|.|.:...|.|:
Mouse  1651 LKDTQLHLDDALRG---QEDLK---------------EQLA-------IVERRANLLQAEVEELR 1690

  Fly  1681 APLLKAVVKVPPLFQQALVMHHHILKYM----GDIARSNLPVNTDLIFQPALQHPLLCDELYCQL 1741
            | .|:...:...|.:|.|:..:..::.:    ..:..:...:.|||                .||
Mouse  1691 A-TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDL----------------TQL 1738

  Fly  1742 MKQLSD--NPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALADACLKRLKRSLAQ- 1803
            ..::.|  ..:..:|::       |...:..:.::..||      :.:....|.|:|:|::|.|
Mouse  1739 QSEVEDACRDARNAEEK-------AKKAITDAAMMAEEL------KKEQDTSAHLERMKKNLEQT 1790

  Fly  1804 -----------------GQRKKAPHL--------IEVEGIQQRCLHIYHKIYFPDDTVE--AFEI 1841
                             |.:|:...|        .|:||.|:|.......:...:..|:  .::.
Mouse  1791 VKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQS 1855

  Fly  1842 ESHTRGAELIADIAQRLELK 1861
            |...:....:.|:..:|::|
Mouse  1856 EEDRKNVLRLQDLVDKLQVK 1875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	275/678 (41%)
		IQ	765..785	CDD:197470	5/41 (12%)
		Atrophin-1	<820..>946	CDD:460830	35/173 (20%)
		MyTH4	1031..1239	CDD:470587	42/263 (16%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	24/100 (24%)
		B41	1248..1429	CDD:214604	38/185 (21%)
		PH-like	1454..1547	CDD:473070	14/97 (14%)
		MyTH4	1674..1819	CDD:214535	29/176 (16%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	4/38 (11%)
		B41	1827..2032	CDD:214604	4/36 (11%)
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myh3	NP_001093105.1	Myosin_N	33..77	CDD:460670	13/47 (28%)
		MYSc_Myh3	100..767	CDD:276878	275/678 (41%)
		Actin-binding. /evidence=ECO:0000250	656..678		11/21 (52%)
		Actin-binding. /evidence=ECO:0000250	758..772		4/13 (31%)
		Myosin_tail_1	847..1924	CDD:460256	224/1267 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1289		5/28 (18%)