Protein Alignment Myo28B1 and hum-1

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_492393.1
• Gene: hum-1 / 172698
• WormBaseID: WBGene00002035
• Length: 1100
• Species: Caenorhabditis elegans
• Alignment Length: 823
• Identity: 287/823 - (34%)
• Similarity: 447/823 - (54%)
• Gaps: 37/823 - (4%)

  Fly    69 VEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELP 133
            |:||:.|..|.|.:|:.||:.|.....|:||.|.:|:::||::.:|.:|.:|:.||:..:..|..
 Worm    16 VDDMVLLPKLTEQSIVENLKKRLQANSIFTYIGPVLISVNPFKQMPYFTEKEMLLYQGAAQYENA 80

  Fly   134 PHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISG---KHSWIEQQIIEAN 195
            |||:|::||.::.:....|:|||:||||||||||.:.|.|:.|::.|||   |...|:..|:::|
 Worm    81 PHIYALADNMYRNMLIDNESQCVIISGESGAGKTVNAKFIMNYISRISGGGQKVQHIKDVILQSN 145

  Fly   196 PIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCM 260
            |::|||||:.||||.||||||||:||.|:..|...|.::..:||||||:|.|:..:||:|:||.:
 Worm   146 PLLEAFGNSATVRNWNSSRFGKYVEIVFSRGGEPIGGKLSNFLLEKSRVVHQNEGDRNFHVFYQL 210

  Fly   261 LAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSL 325
            .||.....|....:.|.  ..|:||...|.|......|.|:|.....||||:....::...:|.:
 Worm   211 CAGADKNLRSTFGIGEL--QYYNYLNMSGVFKADDTDDGKEFESTLHAMKVVGVNDQDQLEVLRI 273

  Fly   326 LAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTI----FVHGEHV 386
            :|.:||:||:.|  ||..|.|.....|  .|:..|.|||:..:.:.|.||.|.:    ....|.:
 Worm   274 VATVLHIGNITF--TEENNFAAVSGKD--YLEYPAFLLGLTSADIEAKLTGRKMESKWGTQKEEI 334

  Fly   387 TTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETIN--KQVDQPMNSIGVLDIFGFENFDNNSF 449
            ...|:.|.|...|||:||::|..:|..:|:::|:.:|  .|......|:|:|||:|||.|:||.|
 Worm   335 DMKLNVEQASYTRDAWVKAIYARLFDYLVKKVNDAMNITSQSTSDNFSVGILDIYGFEIFNNNGF 399

  Fly   450 EQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMK-PMNLMSLID-- 511
            ||.|||:.||.|||.|:....|.||:||..|.|.|..|::.||:.:.|||..| |..:|||:|
 Worm   400 EQFCINFVNEKLQQIFIELTLKAEQEEYVREGIKWTEIDYFDNKIVCDLIETKRPPGIMSLLDDT 464

  Fly   512 --EESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFS 574
              :.....:|.|:.||..|.........:..|..:    |.|:||||.|.||..||.::|||...
 Worm   465 CAQNHGQREGVDRQLLTTLSKSFAGHPHFGPGSDS----FVIKHYAGDVTYNVDGFCDRNRDVLY 525

  Fly   575 GDLRTLVQRSTNKYLVDIFPHEMPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEY 639
            .||..|:|:|:..::..:||..:.....|:..|...|.|...:.|:.:|.:..|:::|||||||.
 Worm   526 PDLILLMQKSSRPFIQALFPENVAASAGKRPTTFSTKIRTQANTLVESLMKCSPHYVRCIKPNET 590

  Fly   640 KEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQ 704
            |.|.::::.....|:.|.|:.|..|:||||:..|.|:..|.:||.::.|...|..|.|.::....
 Worm   591 KRPNDWEESRVKHQVEYLGLRENIRVRRAGFAYRRAFDKFAQRYAIVSPQTWPCFQGDQQRACEI 655

  Fly   705 ICEVALPADSDRQYGKTKLFLRDEDDA-SLELQRSQLMLKSIVTIQRGIRRVLFRR-YMKRYREA 767
            ||:......:..|.||||:|:::.:.. .||..|.:........||:..|:...|: ::|:..:|
 Worm   656 ICDSVHMEKNQYQMGKTKIFVKNPESLFLLEETRERKFDGYARVIQKAWRQFSARKQHIKQKEQA 720

  Fly   768 IITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQK 832
            ...:.    |:.:||:|.:.|   :.:|..|..:...|..::|..|...|.|.:.....||....
 Worm   721 ADLMY----GKKERRRYSLNR---NFVGDYIGLEHHPTLQSLVGKRQRVLFACTANKYDRKFRVT 778

  Fly   833 KLLERRKQNQLKKEELLKLAKMKEAEELLRL-QQLKEQKEREQ 874
            ||......|.|   .|:...|:|...|..:: :.:|.|.:..|
 Worm   779 KLDLLLTVNHL---TLIGKEKVKNGPEKGKIVEVIKRQFDLPQ 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	247/658 (38%)
		IQ	765..785	CDD:197470	4/19 (21%)
		Atrophin-1	<820..>946	CDD:460830	13/56 (23%)
		MyTH4	1031..1239	CDD:470587
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
hum-1	NP_492393.1	MYSc	9..690	CDD:214580	255/683 (37%)
		Myosin_TH1	717..920	CDD:461801	26/112 (23%)
		SH3	1051..1100	CDD:473055