DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and Myo9a

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_599162.2 Gene:Myo9a / 171296 RGDID:621395 Length:2626 Species:Rattus norvegicus


Alignment Length:2522 Identity:605/2522 - (23%)
Similarity:960/2522 - (38%) Gaps:797/2522 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            |:|.:|:.:|.||.|.|:|.||:||:..:.||||.||:|:||||::.||||..:.:::|.|..|.
  Rat   145 QKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLG 209

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQIIE 193
            :|.|||:|::|.|:..:.:.|:|||:|||||||:|||:||..::.:|.|:|  |..|.:||.|:.
  Rat   210 KLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILG 274

  Fly   194 ANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFY 258
            |.|::||||||||..|:|||||||:|::.:...|.:.||.:::|||||||:|:|..:|||||:||
  Rat   275 AGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFY 339

  Fly   259 CMLAGLSTAERERLKLQEQSPSQYHYL------------------AQGGCFTLPGRGDAKDFADI 305
            .:|||.|  |.|||....:.|.:||:|                  ::..|||:.|.....||..:
  Rat   340 YLLAGAS--EEERLAFHLKQPEEYHFLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERL 402

  Fly   306 RAAMKVLSFKPEEVWSILSLLAAILHLGNLRFT----ATEVANLATAEIDDTPNLQRVAQLLGIP 366
            :.||:::.|.|:....|.|||:|||||||:.:.    ..:..::...|:     |..|::||.:.
  Rat   403 QLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYRDDSIDICNPEV-----LPIVSELLEVK 462

  Fly   367 ISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETI----NKQVD 427
            ...|..||..|.....||.:........|:..|::..||||..:|..||.|||..:    :.:.|
  Rat   463 EEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEKD 527

  Fly   428 QPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDN 492
            ....|||||||||||:::||||||.|||:|||.||.:|..||||:||:||:.|.|:|.:|::.||
  Rat   528 TKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDN 592

  Fly   493 QQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGV 557
            ...::||..||..|:.|:||||.||:.|:||||:|...||...| |::........|.|:||||.
  Rat   593 TCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENS-YIEFPAVMEPAFIIKHYAGK 656

  Fly   558 VMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYL--------------------------------- 589
            |.|....|.|||.|....|:..|::.|.|.::                                 
  Rat   657 VKYGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAVVAFREAGKR 721

  Fly   590 -------------------VDIFP------HEMPM------------------------------ 599
                               :|.|.      |:..:                              
  Rat   722 HIQRKSGHDDTTPCTILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNT 786

  Fly   600 -------DT-------------------------------------------------------- 601
                   ||                                                        
  Rat   787 LNEKNQHDTFDIAWNVRTGIRQSRLPTNNTSLLDKDGIFANSASSKLLERAHGILTRNKNFRSKP 851

  Fly   602 ---------------------------------AKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRC 633
                                             .||.|::..:|:.||..||.||.||.|||::|
  Rat   852 VLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQVSLSKLMETLDQAEPYFVKC 916

  Fly   634 IKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDC 698
            |:.|..|.|..|...|.:|||||:||:||.|||::||..:::::.||..:.:|:|......:.:.
  Rat   917 IRSNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPQHIIPSKFNI 981

  Fly   699 RKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKR 763
            :...|:|   .:..| :.|.|||.:||::.:...|:....|.:|:.|:.:||..|.:|.|:....
  Rat   982 QDFFRKI---NINPD-NYQVGKTMVFLKEHERQHLQDLLHQEVLRRIILLQRWFRVLLSRQQFLH 1042

  Fly   764 YREAIITVQRY--------------------------------WRGRLQRRKYQVMRQGF----- 791
            .|:|.:.:||:                                ||..|:|::|..:|...     
  Rat  1043 LRQASVIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQASWRAHLERQRYLELRAAAVIIQQ 1107

  Fly   792 ---------HRLGACIAAQ----QLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQL 843
                     ||...||.::    :.:.|:...|.:.|.||::.||:..|:.::....||.|:.:|
  Rat  1108 RWRELCRRRHRAATCIQSRWRGYRQSKKYKEQRNKIILLQSIYRGFRARQRYKALKEERLKETKL 1172

  Fly   844 KKEELLKLAKMK----------------------------------EAEELLRLQQLKEQKEREQ 874
            :.    .||::|                                  |:..:.|...:...||...
  Rat  1173 EH----GLAQIKTCGPLEIQGSDPSEWEDRSFANRVKAIEECKSVIESNRISRESSMDFSKESPD 1233

  Fly   875 REQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTL-QARNSLPPPPTTLIVA 938
            ::|:..|.|....|:.:...|..........:::....|:|:.:...| ||..||     .|:..
  Rat  1234 KQQERGRSQSGTDLQGDVIVRQRPKSLEDLHQKKVGRAKRESRRMRELEQAIFSL-----ELLKV 1293

  Fly   939 APLPTRPASAVTRINT--IPE---SP-GTIDVESSKQMVDDVFRFLNDE--------PDAALRKL 989
            ..|.....|...|.:|  :||   || ||.|.|||:..::.:....|.:        .|..|:  
  Rat  1294 RSLGGMSPSEERRWSTELMPEGLQSPQGTPDSESSQGSLELLTCDENQKSKPESLILDDGELK-- 1356

  Fly   990 NNISSGDTIRLPK--SVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLK-----KSLLKHEHPI 1047
              |||..|...||  |..|.:..|.    :.::|:.|.||::..|.  ||     :.|:....||
  Rat  1357 --ISSPSTFTNPKFDSQNNALSASS----ETSSTFSGKGASSDSEH--LKNGTAEEKLVYSSQPI 1413

  Fly  1048 -------DEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQ 1105
                   |...|.:  |....::.....:.:|..|......|.:.:..:.|.|:       ....
  Rat  1414 TCKSQLRDSFVSSS--LPTFFYIPHQEPLKTSSQLDTSIQRNKLPERETTLKTT-------LTLD 1469

  Fly  1106 SQRRIPKPLASGEKEAQEFYQHWLNVPTS-----HLEKIHFIIGHGIIKNSLRD---------EI 1156
            ..|...|...||:...       ||..:|     .|||::       |:...|.         |:
  Rat  1470 INREARKCQFSGQVTP-------LNPDSSCTVLKKLEKLN-------IEKEKRQKQLQQQNEKEM 1520

  Fly  1157 LAQICKQL-YLNPSRSSY---SRGWLLLSLCLSCFPPSKE-----FEPHLRSFMKQGTAQLQATP 1212
            :.||.:|. .|...|.::   .:.....||....|..|::     ...|:::...:|.|.:..:|
  Rat  1521 MEQIRQQTDILEKERKAFKTIEQSRTEASLLAPSFYQSRQKVERPSSLHIQNTPSKGEAGVLGSP 1585

  Fly  1213 S-LQRLERTLVN-GPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQ 1275
            | |...:...:: .|:.:|.:||                    .:|:.....:.|.:|...  .:
  Rat  1586 SALATKDSPSIHLPPKDRPVTLF--------------------FERKGSPCQSRTVKELTK--TE 1628

  Fly  1276 GMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQRQLDAPWKLYIRKEMFATWYDPSMDP 1340
            .||........|..:.|.:       :||.....|  ...:.|.|.:....:.:|.|    ..|.
  Rat  1629 RMGTQHDAACRLSNNRNTE-------REHFKSTHS--YSHRSDDPSREGSSRPIFFT----PKDN 1680

  Fly  1341 KATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPG--EILR--LKPSEITAFVPSDLL 1401
            ..|.|::.        |..:...:.:.|....||     |||  |:.|  .|.....|...||.|
  Rat  1681 VITPLVHS--------GNPQVHKQDEPAWKSKLA-----GPGQREVARPAHKKKARMARTRSDFL 1732

  Fly  1402 APGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPM------RHSRLF 1460
            ..|..|            :.....:|:..|.::|                 |:      .||.| 
  Rat  1733 TRGTFA------------DGEGDTEEDDYDDIIE-----------------PLLSLDQASHSEL- 1767

  Fly  1461 EVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVL 1525
                  ||          ::|.|.....::|  :.|..||.     |:...:||....|  ..:.
  Rat  1768 ------GP----------VSSLGQASHSDSE--MTSQRFSS-----VDEQARLHKAMSQ--GEIT 1807

  Fly  1526 QCSSAQDANEVINYMLDNLRQRSSY------------GVALDPVVEGDL------EDCLVLNP-- 1570
            :.:..|.:::     ||...||:..            ...:.|..:.::      .|...::|  
  Rat  1808 KLAGRQKSSD-----LDIRPQRAKMRFWAKGKQGEKKTTRVKPAPQSEVSSLFAGSDVTPVHPFS 1867

  Fly  1571 GDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKP-SEKLQDILREGRFQE 1634
            .:|.::..                                      |.| |.:|....|: .|:|
  Rat  1868 DELTQYHP--------------------------------------TPPLSPELPGSCRK-EFKE 1893

  Fly  1635 PPKPTPRANYSRRRQHNISQLAESHFREPLDS-----DKAPLSKFSPEPLKAPLLKAVVKVPPLF 1694
            ..:|:|:|  .|:|...||.:|       |||     |...:.. |...||:             
  Rat  1894 NKEPSPKA--KRKRGVKISSVA-------LDSMHWQNDSVQIIA-SANDLKS------------- 1935

  Fly  1695 QQALVMHHHILKYMGDIARSNLPVNT--DLIFQPALQH-----------PLLCD--------ELY 1738
                 |...:||.|.|:...:...:|  |::|:.||:.           .|..|        :||
  Rat  1936 -----MDEFLLKKMNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSSYSSALAMDDGKSIRYKDLY 1995

  Fly  1739 CQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLV---MRELIILLRMRADALADACLK--RLK 1798
            . |.:|:.:. :...|:|.|:...:...:....|.:   |.|...|     |:.|...||  |.|
  Rat  1996 A-LFEQILEK-TMRFEQRDWNESPVRVWVNTFKVFLDEYMNEFKTL-----DSTAPKVLKTERKK 2053

  Fly  1799 RSLAQGQRKKAPHLIEVEG-----------------------IQQR------CLHIYH------- 1827
            |      |||...|:|...                       |..|      |.:..|       
  Rat  2054 R------RKKETDLVEEHNGHMFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKT 2112

  Fly  1828 -----KIYFPDDTVEAFEIE-----SHTRGAELIAD-IAQRLELKSPVGYSIFLKTGDRVYAMPE 1881
                 |.|.|:.:...|.:|     |..|...|:.: :...:|:.......|:.|:|.       
  Rat  2113 TAKCSKKYDPELSSRQFGVELSRLTSEDRAVPLVVEKLINYIEMHGLYTEGIYRKSGS------- 2170

  Fly  1882 EEFVFDFITQLIYWLRQ--QRTIRSISDGQYQLHFMR---KLWLNNHPGEDLNGDMIFSY----- 1936
                    |..|..|||  .....|::...|.:|.:.   |.||.:.|...:..::...:     
  Rat  2171 --------TNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMG 2227

  Fly  1937 PQELHKYLKGYYPIDCEQASRLAILVYSADHDVSLQRLPEVLTRL-------------------- 1981
            .||..:.::|.|.: .:|.||        .|..:|:||...|.|:                    
  Rat  2228 LQERKETIRGVYSV-IDQLSR--------THLSTLERLIFHLVRIALQEDTNRMSANALAIVFAP 2283

  Fly  1982 ----IPEDLIPLQTVAEWRQQILPKVHRDHLTEDHAKILFLQELSHFACFGSTFFVVKQQN---- 2038
                .|:...|||:|                 :|.:|.....||          .||:|.|    
  Rat  2284 CILRCPDTTDPLQSV-----------------QDISKTTTCVEL----------IVVEQMNKYKA 2321

  Fly  2039 --DDALPETLLIAIN--STGFHMLDPTTKEILRSYEYSQLGIWS-SGKNHFH 2085
              .|.  .:|..|.|  .|...::..:.|.:|.:..:..:...| |||...|
  Rat  2322 RLKDI--SSLEFAENKAKTRLSLIRRSMKPVLIAVRFMSITRSSVSGKGRLH 2371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 291/882 (33%)
MYSc_Myo7 81..726 CDD:276832 282/856 (33%)
IQ 765..785 CDD:197470 8/51 (16%)
DUF4355 827..>887 CDD:290964 15/93 (16%)
MyTH4 1031..1239 CDD:295320 46/244 (19%)
B41 1248..1429 CDD:214604 34/184 (18%)
FERM_N 1248..>1288 CDD:286467 5/39 (13%)
FERM_B-lobe 1342..1429 CDD:271216 19/90 (21%)
PH-like 1454..1547 CDD:302622 18/98 (18%)
MyTH4 1674..1819 CDD:214535 38/193 (20%)
B41 1827..2032 CDD:214604 47/256 (18%)
FERM_N 1829..>1877 CDD:286467 11/53 (21%)
FERM_M 1936..2032 CDD:278785 22/124 (18%)
FERM_C2_MyoVII 2028..2121 CDD:270020 16/67 (24%)
Myo9aNP_599162.2 Actin-binding. /evidence=ECO:0000250 908..919 7/10 (70%)
Neck or regulatory domain. /evidence=ECO:0000250 1022..1163 28/140 (20%)
Tail. /evidence=ECO:0000250 1164..2589 284/1491 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1276 10/54 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1397 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1562..1602 7/39 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1618..1673 11/65 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1689..1726 10/41 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1765..1784 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1872..1907 12/75 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2365..2385 4/7 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2449..2527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2552..2614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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