DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and MYO3B

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	XP_011508956.1	Gene:	MYO3B / 140469	HGNCID:	15576	Length:	1386	Species:	Homo sapiens

Alignment Length:	1140	Identity:	352/1140 - (30%)
Similarity:	540/1140 - (47%)	Gaps:	239/1140 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVE------DMITLGDLQEYTILRNLQ 88
            |::::.:|.|..|...|:::.     ...:..|:   ||.|      |::.|..|.|.||:..||
Human   317 AKVLQDQKHQNPVAKTRHERM-----HTRRPYHV---EDAEKYCLEDDLVNLEVLDEDTIIHQLQ 373

  Fly    89 NRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKEN 153
            .|||..|||||.|.:|:|:||:|.|.||:.:..:||.....|..||||||.:|.|:|.:..|.::
Human   374 KRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKD 438

  Fly   154 QCVVISGESGAGKTESTKLILQYLAAISGK--HSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFG 216
            ||:|||||||:|||||..||:|:|..: ||  :..:.::|::.|.::|||||:.|..||||||||
Human   439 QCIVISGESGSGKTESAHLIVQHLTFL-GKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFG 502

  Fly   217 KYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAER-ERLKLQEQSPS 280
            ||:|:.|||.|.:.||||.:|||||||::.|:..|:|:||||.:.|||...:: ...:|.|:.|.
Human   503 KYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPP 567

  Fly   281 QY---------HYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLR 336
            :|         |.:.....:       .:.|..|:...:::.|..:||.|:..:||.||::||:.
Human   568 RYIADETGRVMHDITSKESY-------RRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIE 625

  Fly   337 FTATEVANLATAEIDDTPN---LQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEG 398
            |.|  :::....:..:.||   ||..|.:|.|....|..|||...:...||.:..:.:.:.|.:.
Human   626 FAA--ISSQHQTDKSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADV 688

  Fly   399 RDAFVKSLYDGIFVRIVRRINETINKQVDQPMNS------IGVLDIFGFENFDNNSFEQLCINYA 457
            |||..|:||..:|..||.|||..:  |.|:.:.|      :|:|||||||||..|||||||||.|
Human   689 RDAMSKALYGRLFSWIVNRINTLL--QPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCINIA 751

  Fly   458 NENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQ 522
            ||.:|.:|..|:|.:||.|||||.|:...:|::||:.:||:...||:.|::|:||||:||:.|||
Human   752 NEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ 816

  Fly   523 TLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNK 587
            ||::|.  :...|..|..........|||:||||.|:|:..|.||||||:...|:..:::.|.||
Human   817 TLVDKF--EDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENK 879

  Fly   588 YLVDIF-------------------------PH----EMPMDTAK-----------KQPTLCVKF 612
            .|..:|                         ||    :..:||.:           |:.|:...|
Human   880 LLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYF 944

  Fly   613 RNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYR 677
            |.||..|:..:....|:|:||||||:.:|...|.:|..:.|||.:|::||..|||.||..|..:.
Human   945 RYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFE 1009

  Fly   678 AFVERYRLLV-----PPVGPLEQCDCRKLARQICEVALPADSDRQY---GKTKLFLRDEDDASLE 734
            .||:||..|.     .|:...|.|           ||:...|...:   ||||:||:     ...
Human  1010 EFVKRYYYLAFTAHQTPLASKESC-----------VAILEKSRLDHWVLGKTKVFLK-----YYH 1058

  Fly   735 LQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIA 799
            :::..|:|:.::                   ..::.:|.|.:|.|..|:|:.:|:...: ||
Human  1059 VEQLNLLLREVI-------------------GRVVVLQAYTKGWLGARRYKRVREKREK-GA--- 1100

  Fly   800 AQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQ-----------NQLKKEELLKLAK 853
                           |.:|:..|||..|:.| ||:..||.:           ||.........|.
Human  1101 ---------------IAIQSAWRGYDARRKF-KKISNRRNESAAHNQAGDTSNQSSGPHSPVAAG 1149

  Fly   854 MKEAEELLRLQQLKE------------QKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQK 906
            .:.:.|   :|...|            ::...|.|....|.|......| ...:|......:|.:
Human  1150 TRGSAE---VQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPA-VTEKNGSHSCDIQTR 1210

  Fly   907 RRTKPVKQE------------------------APKAPTLQA--RNSLPPPPTTLI---VAAPLP 942
            .|.:..:||                        :||...:.|  .|......|.|:   :..|.|
Human  1211 AREEHPRQEKQEWAIARGRICRAILGRHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAP 1275

  Fly   943 TRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNN 1007
            .:...::.   ..|:.||:.:..:.|...          |....::            ||.:.:.
Human  1276 DQQGLSLW---GAPQKPGSENGLAQKHRT----------PRRRCQQ------------PKMLSSP 1315

  Fly  1008 IDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLK 1042
            .||..::.|.....|.|.      :|||.|...:|
Human  1316 EDTMYYNQLNGTLEYQGS------KRKPRKLGQIK 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	284/749 (38%)
		MYSc_Myo7	81..726	CDD:276832	275/713 (39%)
		IQ	765..785	CDD:197470	5/19 (26%)
		DUF4355	827..>887	CDD:290964	16/82 (20%)
		MyTH4	1031..1239	CDD:295320	5/12 (42%)
		B41	1248..1429	CDD:214604
		FERM_N	1248..>1288	CDD:286467
		FERM_B-lobe	1342..1429	CDD:271216
		PH-like	1454..1547	CDD:302622
		MyTH4	1674..1819	CDD:214535
		B41	1827..2032	CDD:214604
		FERM_N	1829..>1877	CDD:286467
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808
		S_TKc	36..302	CDD:214567
		MYSc	355..1062	CDD:214580	280/736 (38%)
		MYSc_Myo3	366..1055	CDD:276830	275/713 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810