Protein Alignment Myo28B1 and MYO3B

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_011508956.1
• Gene: MYO3B / 140469
• HGNCID: 15576
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 1140
• Identity: 352/1140 - (30%)
• Similarity: 540/1140 - (47%)
• Gaps: 239/1140 - (20%)

  Fly    30 ARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVE------DMITLGDLQEYTILRNLQ 88
            |::::.:|.|..|...|:::.     ...:..|:   ||.|      |::.|..|.|.||:..||
Human   317 AKVLQDQKHQNPVAKTRHERM-----HTRRPYHV---EDAEKYCLEDDLVNLEVLDEDTIIHQLQ 373

  Fly    89 NRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKEN 153
            .|||..|||||.|.:|:|:||:|.|.||:.:..:||.....|..||||||.:|.|:|.:..|.::
Human   374 KRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKD 438

  Fly   154 QCVVISGESGAGKTESTKLILQYLAAISGK--HSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFG 216
            ||:|||||||:|||||..||:|:|..: ||  :..:.::|::.|.::|||||:.|..||||||||
Human   439 QCIVISGESGSGKTESAHLIVQHLTFL-GKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFG 502

  Fly   217 KYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAER-ERLKLQEQSPS 280
            ||:|:.|||.|.:.||||.:|||||||::.|:..|:|:||||.:.|||...:: ...:|.|:.|.
Human   503 KYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPP 567

  Fly   281 QY---------HYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLR 336
            :|         |.:.....:       .:.|..|:...:::.|..:||.|:..:||.||::||:.
Human   568 RYIADETGRVMHDITSKESY-------RRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIE 625

  Fly   337 FTATEVANLATAEIDDTPN---LQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEG 398
            |.|  :::....:..:.||   ||..|.:|.|....|..|||...:...||.:..:.:.:.|.:.
Human   626 FAA--ISSQHQTDKSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADV 688

  Fly   399 RDAFVKSLYDGIFVRIVRRINETINKQVDQPMNS------IGVLDIFGFENFDNNSFEQLCINYA 457
            |||..|:||..:|..||.|||..:  |.|:.:.|      :|:|||||||||..|||||||||.|
Human   689 RDAMSKALYGRLFSWIVNRINTLL--QPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCINIA 751

  Fly   458 NENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQ 522
            ||.:|.:|..|:|.:||.|||||.|:...:|::||:.:||:...||:.|::|:||||:||:.|||
Human   752 NEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ 816

  Fly   523 TLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNK 587
            ||::|.  :...|..|..........|||:||||.|:|:..|.||||||:...|:..:::.|.||
Human   817 TLVDKF--EDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENK 879

  Fly   588 YLVDIF-------------------------PH----EMPMDTAK-----------KQPTLCVKF 612
            .|..:|                         ||    :..:||.:           |:.|:...|
Human   880 LLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYF 944

  Fly   613 RNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYR 677
            |.||..|:..:....|:|:||||||:.:|...|.:|..:.|||.:|::||..|||.||..|..:.
Human   945 RYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFE 1009

  Fly   678 AFVERYRLLV-----PPVGPLEQCDCRKLARQICEVALPADSDRQY---GKTKLFLRDEDDASLE 734
            .||:||..|.     .|:...|.|           ||:...|...:   ||||:||:     ...
Human  1010 EFVKRYYYLAFTAHQTPLASKESC-----------VAILEKSRLDHWVLGKTKVFLK-----YYH 1058

  Fly   735 LQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIA 799
            :::..|:|:.::                   ..::.:|.|.:|.|..|:|:.:|:...: ||
Human  1059 VEQLNLLLREVI-------------------GRVVVLQAYTKGWLGARRYKRVREKREK-GA--- 1100

  Fly   800 AQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQ-----------NQLKKEELLKLAK 853
                           |.:|:..|||..|:.| ||:..||.:           ||.........|.
Human  1101 ---------------IAIQSAWRGYDARRKF-KKISNRRNESAAHNQAGDTSNQSSGPHSPVAAG 1149

  Fly   854 MKEAEELLRLQQLKE------------QKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQK 906
            .:.:.|   :|...|            ::...|.|....|.|......| ...:|......:|.:
Human  1150 TRGSAE---VQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPA-VTEKNGSHSCDIQTR 1210

  Fly   907 RRTKPVKQE------------------------APKAPTLQA--RNSLPPPPTTLI---VAAPLP 942
            .|.:..:||                        :||...:.|  .|......|.|:   :..|.|
Human  1211 AREEHPRQEKQEWAIARGRICRAILGRHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAP 1275

  Fly   943 TRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNN 1007
            .:...::.   ..|:.||:.:..:.|...          |....::            ||.:.:.
Human  1276 DQQGLSLW---GAPQKPGSENGLAQKHRT----------PRRRCQQ------------PKMLSSP 1315

  Fly  1008 IDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLK 1042
            .||..::.|.....|.|.      :|||.|...:|
Human  1316 EDTMYYNQLNGTLEYQGS------KRKPRKLGQIK 1344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	275/713 (39%)
		IQ	765..785	CDD:197470	5/19 (26%)
		Atrophin-1	<820..>946	CDD:460830	33/177 (19%)
		MyTH4	1031..1239	CDD:470587	5/12 (42%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808
		MYSc_Myo3	366..1055	CDD:276830	275/713 (39%)