Protein Alignment Myo28B1 and myo7b

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_002936659.2
• Gene: myo7b / 100491953
• -ID: -
• Length: 2118
• Species: Xenopus tropicalis
• Alignment Length: 2259
• Identity: 856/2259 - (37%)
• Similarity: 1262/2259 - (55%)
• Gaps: 292/2259 - (12%)

  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV--LKAMHITSQEDVE 70
            |:||:||:: .:::|:..||.||.:..:..|:|||.||..|:.|:.|.::  :..||.:....||
 Frog     5 RQGEHVWLE-ASSSSQSKVPIGAVVKNSHGTETLVVDDDGKEHWISARNISSVHPMHPSLAHGVE 68

  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPH 135
            |||.||:|.|..|:.|:..||.:..|||||||:|||:||||.||:|...::::|||:.:.|||||
 Frog    69 DMIRLGELNEAGIVHNIHIRYKENNIYTYTGSILVAVNPYQELPLYDTEQLEMYRNRRIGELPPH 133

  Fly   136 IFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEA 200
            |||:.|..|..:||...:||.||||||||||||||||:||:||:.||:||||||||:||||||||
 Frog   134 IFALGDTCFFNMQRTNTDQCCVISGESGAGKTESTKLMLQFLASASGQHSWIEQQILEANPIMEA 198

  Fly   201 FGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLS 265
            ||||||:||||||||||||||.|:.:..|:||||:|:||||||:..||..|||||||||||.|:.
 Frog   199 FGNAKTIRNDNSSRFGKYIEIHFSNKHVIEGARIEQFLLEKSRVCRQSPGERNYHIFYCMLLGMG 263

  Fly   266 TAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAIL 330
            :.::::|.|  :|||.|.||..|.|....||.|.|.|:.||.|||:|.....|...|..:|||||
 Frog   264 SEQKKQLNL--ESPSDYKYLTMGNCTNCDGRDDHKAFSQIRTAMKILLLSEIEQQEIFKMLAAIL 326

  Fly   331 HLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAA 395
            |||||:|.|....||...::.::.:|..||.||.:..:.|...|:..||.|.||.|:..||...|
 Frog   327 HLGNLKFKAAMCGNLECCDVPESIHLSTVATLLEVDSAQLTNCLSNHTIIVRGESVSKPLSCTQA 391

  Fly   396 IEGRDAFVKSLYDGIFVRIVRRINETI-NKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANE 459
            .:.||||||.:|..:|:.||.:||:.| ....:....|:|:|||||||:||.|||||||||:|||
 Frog   392 SDSRDAFVKGIYGRLFMWIVNKINKAIFTPDSENGRRSVGLLDIFGFEHFDTNSFEQLCINFANE 456

  Fly   460 NLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTL 524
            :||||||.||||:||:||..|.|.|:||:|.|||:.||:|.::|:|::||||||||||:|||.|:
 Frog   457 HLQQFFVRHIFKLEQEEYNAEQIPWEHIDFSDNQRTLDVIALRPLNIISLIDEESKFPQGTDATM 521

  Fly   525 LEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYL 589
            |.||:..|...::|:..|:...:.|||.||||:|.|...|||:||||..|.|:..::..|:|.:|
 Frog   522 LVKLNNVHSKTNVYIASKSVHDTKFGINHYAGIVYYETEGFLDKNRDLLSTDIMLMIHTSSNYFL 586

  Fly   590 VDIFPHE--------------------MPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCI 634
            ..:|..|                    ...||.:..|||..:|:.||:.||:.|....|||||||
 Frog   587 KQVFQMEKITKSSGSVTYRHIINSYSQKTADTNRSLPTLGGQFKQSLEQLMKILESCQPYFIRCI 651

  Fly   635 KPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCD-- 697
            ||||:|:||.||:|||:|||:|||||||.|||:||||||:::..|.:|||:|:|...|..:.:
 Frog   652 KPNEFKKPKMFDRELCIRQLQYSGMMETIRIRKAGYPIRYSFSEFFQRYRVLLPIQSPYRKKENF 716

  Fly   698 ---CRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRR 759
               |..:|:.:    :....|.:.|||||||:|..|..||::|.:.:..|.:.||:.:|....|:
 Frog   717 REGCIDIAKSV----IGKHEDWKVGKTKLFLKDNHDTKLEVERDKAITASAIRIQKVVRGYKDRK 777

  Fly   760 YMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGY 824
            ...|.|||.|.:|..|:....|:.:|.|..||.||.|.|.::.:..::...|...|:||.|||||
 Frog   778 RFLRQREAAIKIQSAWKSYYCRKTFQKMLHGFQRLQAIIRSRPVQMQYKKKREVIIQLQGLSRGY 842

  Fly   825 LVRKDFQKK-------------LLERRKQNQLKKEELLKLAKMKEAEELLRLQQ-LKEQKEREQR 875
            |:||...|:             :|.|::..::|:.|.......:|||:...:|: |..|:|:|..
 Frog   843 LLRKKIAKRKNAVLVLQTYTRGMLARKEYRRMKRNEYPSQQDWEEAEKRKEMQKALLLQQEKENL 907

  Fly   876 EQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAP 940
            |..|                                           |....||        |..
 Frog   908 EMVE-------------------------------------------QVFGFLP--------AMD 921

  Fly   941 LPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVP 1005
            :.|.|.|            ..||:::           |..|||
 Frog   922 MDTSPFS------------DEIDLDT-----------LLYEPD---------------------- 941

  Fly  1006 NNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVV 1070
               ...::::.|:|||||.|.||..|.||.|::.||.||...|.:||.|:|..||||||:||:
 Frog   942 ---KEEEYTFPKFAATYFQGSATDTHIRKALQQPLLYHEDKNDVLASLAVWKIILRFMGELPE-- 1001

  Fly  1071 SSPTLHVFDNENLMSDLASLL-----------NTSDSYK---PRL-------------FVRQSQ- 1107
              |.|:   ..|..|:.:|:|           |.:...|   |::             ..|.|:
 Frog  1002 --PALY---TPNSSSERSSVLTQIYDTLTRKNNITAGIKDNVPKVNKKGKGKEISSMKLKRASKL 1061

  Fly  1108 -RRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRS 1171
             .::.:.|::||:...| ....::.|.|:|||||||.|:||::..:||||..||||||..|.:::
 Frog  1062 AGQVSRQLSNGEEIMLE-ESSIIDKPMSNLEKIHFIAGNGILRPEIRDEIYCQICKQLSGNNNKT 1125

  Fly  1172 SYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATP-SLQRLERTLVNGPRCQPPSLFEL 1235
            |.:|||:||:|||.|||||.:|..:|::|::  |:|:.... .::||.|||.||.|.:|||..||
 Frog  1126 SVARGWILLALCLGCFPPSDKFLRYLQNFIR--TSQIAYNAICIKRLNRTLQNGVRSEPPSWLEL 1188

  Fly  1236 HAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGA 1300
            .||:|.....:.:.||.|....:|.|:|:.|||....:.|.:.|.|||||.:.:|:..|:..||.
 Frog  1189 QAIKGVGSFSVPVTLMTGHSMNIQTDSATNAREMCKVIAQKLQLKDTFGFSVYISVYNKVWSLGF 1253

  Fly  1301 GQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGE 1358
            |.||::|.||:|||       ::..:||:|..|||:|..|:|.|.|..:|:|||.|::.||..||
 Frog  1254 GSEHLMDGISQCEQLAKEQGEQERHSPWRLNFRKEIFTPWHDSSTDSVSTELIYCQVIRGLCFGE 1318

  Fly  1359 YRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGE---RAIENWSRLIAATYE 1420
            |||..|:::|.:.....:::|  ||:|   ..:....|..|.:.|.:   :.:.:|..|:.....
 Frog  1319 YRCDKEQELAELMLKHHYIKY--GEVL---TDQHVESVMQDCVPPKQLETKQMSHWLSLLKERQA 1378

  Fly  1421 KSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLF 1485
            .:.||||:...|      :.||....::.|.||:..|:.||..:..||.:..:..::.||...:.
 Frog  1379 VAQYVKEKHPAL------QVKEAFVEYSRLQWPLLFSKFFEASKFTGPSISRNHFIVAINWKEIN 1437

  Fly  1486 LIDETEQVLASCCFSEVLKVHVESDDKLH-----VMTFQHVNFVLQCSSAQDANEVINYMLDNLR 1545
            .:||.|:.|....|.|::.:..:..:|..     :.|.:...|||....:.:...::.|.||.|:
 Frog  1438 FLDEKEKRLLQLSFPELIGIRTKRAEKTFGQCCILNTLRGEEFVLTSQHSDEIAHLLLYFLDELK 1502

  Fly  1546 QRSSYGVALD-------------PVVEGDLEDCLVLNPGDLIEF----EAGVTGAQLMAGNAQDC 1593
            .||.|.|||.             ...:.|..|.|....||::..    |..:....:.|.|.:
 Frog  1503 ARSHYAVALQDSSHTVKESLSSTKKAQTDEPDLLSFRSGDVLLLDRSPELQLRANWIFAKNER-- 1565

  Fly  1594 YRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDIL------REGRF----------QEPPKPTPRA 1642
                 .|:.|.....::.::.||:.||.::..::      |:..|          ||..||
 Frog  1566 -----TGKTGAVSLSSIHIIPTLSTPSSEILRLIVMSPEERKSEFYNALVEDFEKQEEVKP---- 1621

  Fly  1643 NYSRRRQHNISQLAESHFREPLDSDKAPLSK--------------FSPEPLKAPLLKAVVKVPPL 1693
                   :.:.:.:..|||.|   |...||:              :|.|||:.|||:.|.::..|
 Frog  1622 -------YTLEEFSLHHFRNP---DPESLSRAVLQRSRGKTHLWAYSREPLRQPLLRKVCEISDL 1676

  Fly  1694 FQQALVMHHHILKYMGDI--ARSNLPVN-TDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESEK 1755
            ...|......|:|||||.  .:::.||. ||.||...::...|.||:|||::||::.|..|.|..
 Frog  1677 RDYACTAFTAIMKYMGDYPSKQTHSPVELTDQIFSGPIKEEALRDEIYCQILKQMTGNSKSYSVN 1741

  Fly  1756 RGWDLLYLATGLVAPSVLVMRELIILLRMR-ADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQ 1819
            .||.||:|.|||..|:.|::..:...:..| .:.||.|.|:|:.|....|.||:.|||:|||.||
 Frog  1742 SGWQLLWLCTGLFPPTKLLLVHVKKFIENRQKEPLAKASLRRILRVQQYGARKQPPHLVEVEAIQ 1806

  Fly  1820 QRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMPEEEF 1884
            |....||||:|||:...|.||:.::|:..||..:|:.:|:|.|..|:|:|||.||:|.:..|:::
 Frog  1807 QMSTKIYHKVYFPNGKEETFEVGTNTKVRELCQNISSKLQLTSWEGFSLFLKIGDKVISQNEQDY 1871

  Fly  1885 VFDFITQLIYWLRQQR-TIRSISDGQYQLHFMRKLWLNNHPGEDLNGDMIFSYPQELHKYLKGYY 1948
            .:|.:.||..::|:.| |..:.:...:||:||||||:|..||:|:..|.||.|.||:.||::||.
 Frog  1872 FYDSLRQLNDFIRKTRPTAGTPAFASFQLYFMRKLWINVQPGKDIKADCIFHYHQEVPKYMRGYN 1936

  Fly  1949 PIDCEQASRLAILVYSADHD---VSLQRLPEVLTRLIPEDLIPLQTVAEWRQQILPKVHR-DHLT 2009
            ....|.|..||.|:|...::   ..|..|.:.:..|:||.|:.|.|..||::.|:...:: :..|
 Frog  1937 LCSVEDAVNLAGLMYKVQYNNDRTHLATLNKNVRDLVPEYLLRLSTPEEWKKNIIAAYNKHEAKT 2001

  Fly  2010 EDHAKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQL 2074
            .|.||:.||:::..:..|||.||.|||.::.:.|:.:|||||..|..:..|.|||:|.::.::::
 Frog  2002 VDEAKVAFLRQICRWPTFGSAFFEVKQSSEPSYPDIVLIAINKHGVSLFHPKTKELLITHPFNKI 2066

  Fly  2075 GIWSSGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYVKY-FNEHE 2122
            ..|:||..:|.:..|:::..:|:||.|:.||||||||.||:.| .::|:
 Frog  2067 SRWNSGNTYFQMTTGSLVRDNKILCETSLGYKMDDLLTSYIHYIMSKHQ 2115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	348/670 (52%)
		IQ	765..785	CDD:197470	7/19 (37%)
		Atrophin-1	<820..>946	CDD:460830	28/139 (20%)
		MyTH4	1031..1239	CDD:470587	92/237 (39%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	36/97 (37%)
		B41	1248..1429	CDD:214604	67/190 (35%)
		PH-like	1454..1547	CDD:473070	22/97 (23%)
		MyTH4	1674..1819	CDD:214535	59/148 (40%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	38/94 (40%)
		B41	1827..2032	CDD:214604	78/209 (37%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	39/93 (42%)
myo7b	XP_002936659.2	MYSc_Myo7	79..744	CDD:276832	348/670 (52%)
		IQ	759..779	CDD:197470	5/19 (26%)
		IQCD	776..805	CDD:467745	10/28 (36%)
		CBD_MYO6-like	<844..>872	CDD:409646	5/27 (19%)
		MyTH4	964..1192	CDD:214535	92/237 (39%)
		B41	1199..1412	CDD:214604	74/223 (33%)
		FERM1_F1_Myosin-VII	1199..1294	CDD:340612	36/94 (38%)
		FERM_C1_MyoVII	1406..1504	CDD:270019	22/97 (23%)
		SH3	1505..1570	CDD:473055	14/71 (20%)
		MyTH4	1657..1806	CDD:214535	59/148 (40%)
		FERM2_F1_Myosin-VII	1811..1907	CDD:340613	38/95 (40%)
		B41	1814..2024	CDD:214604	78/209 (37%)
		FERM_C2_MyoVII	2020..2112	CDD:270020	39/91 (43%)