DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and myo7a

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	XP_004912319.1	Gene:	myo7a / 100491335	XenbaseID:	XB-GENE-494060	Length:	2212	Species:	Xenopus tropicalis

Alignment Length:	2248	Identity:	944/2248 - (41%)
Similarity:	1317/2248 - (58%)	Gaps:	230/2248 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV--LKAMHITSQEDVEDM 72
            |:|||: ...|..||.||.||.:...:..|..|.||...:.|:...:.  :|.||.||...||||
Frog    36 GDYVWL-DLKTGREFDVPVGAVVKLCDSGQIQVLDDEGNEHWISPQNASHIKPMHPTSIHGVEDM 99

  Fly    73 ITLGDLQEYTILRNLQNRYAKQLIY------TYTGSMLVAINPYQILPIYTNREIQLYRNKSLAE 131
            |.||||.|..|||||..||.:.|||      |||||:|||:||||:|||||..:|:||.|:.:.|
Frog   100 IRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTPDQIRLYTNRKIGE 164

  Fly   132 LPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANP 196
            :|||||||:||.:..:||..::||.:||||||||||||||||||:||||||:|||||||::||||
Frog   165 MPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEANP 229

  Fly   197 IMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCML 261
            |:||||||||:||||||||||||:|.|..:|||:||:|:||||||||:..|::||||||||||||
Frog   230 ILEAFGNAKTIRNDNSSRFGKYIDIHFNKKGAIEGAKIEQYLLEKSRVCRQAQDERNYHIFYCML 294

  Fly   262 AGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLL 326
            .|:|..::::|.|.:  .|.|:||..|.|.|..||.|:|::|:||:|||||.|...|.|.|..||
Frog   295 KGMSPEQKKKLSLGQ--ASDYNYLCMGKCTTCDGRDDSKEYANIRSAMKVLMFTDTENWEISRLL 357

  Fly   327 AAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLS 391
            |||||:||||:.|....||...|:..:.:|...|.||.:....|...||.|||...||.|:|.||
Frog   358 AAILHMGNLRYEARMYDNLDACEVVYSTSLTTAATLLEVGPQELMNCLTSRTIITRGETVSTPLS 422

  Fly   392 KEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQV-DQP---MNSIGVLDIFGFENFDNNSFEQL 452
            .|.|::.||||||.:|..:||.||.:||..|.:.: ::|   ..|||:|||||||||..||||||
Frog   423 MEQALDVRDAFVKGIYGRLFVWIVDKINAAIYRPLSNEPKAARRSIGLLDIFGFENFTVNSFEQL 487

  Fly   453 CINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFP 517
            |||:||||||||||.|:||:||:||..|:||||||||.|||..||:|.:||||::||||||||||
Frog   488 CINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFP 552

  Fly   518 KGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQ 582
            ||||.|:|.||:|||...:.|:..|....:.|||.|:||:|.|...||||||||:..||:..||.
Frog   553 KGTDTTMLNKLNVQHKLNTFYIPPKNNYETQFGINHFAGIVYYETKGFLEKNRDTLHGDIIQLVH 617

  Fly   583 RSTNKYLVDIFPHEMPM--DTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNF 645
            .:.||::..||..::.|  :|.|:.|||..:|:.||::||||||...|:|:|||||||||:|..|
Frog   618 SAKNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLF 682

  Fly   646 DKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP-LEQCDCRKLARQICEVA 709
            |:|||||||||||||||.||||||||||:.:..||:|||:|:|.|.| .:|.|.|....:|.|..
Frog   683 DRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQGDLRGTCERIAESV 747

  Fly   710 LPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRY 774
            |..|.|.|.||||:||:|..|..||::|.:.:...::.||:.:|....|....:.|:|.:.:||.
Frog   748 LGKDDDWQIGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKIRKAALLIQRC 812

  Fly   775 WRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKL----- 834
            |||...||.|..||.||.||.|...:::|.|::.:.|.|....||..|||||||.|:.:|
Frog   813 WRGHNCRRNYTAMRIGFLRLQALYRSRKLHTQYHVARMRISYFQARCRGYLVRKAFRHRLWAVYT 877

  Fly   835 --------LERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKAE 891
                    :.||...:||.|...:|    |||: |||    .::||.::|...|:.::|    ||
Frog   878 IQAHARGMIARRLYKRLKGEYHRRL----EAEK-LRL----AEEERFKKEMSAKKAKQE----AE 929

  Fly   892 AAARNALAMAAVQQKRRTKPVKQEAPKAPTL-----QARNSLPPPPTTLI--------VAAPLPT 943
            ...:..||..|.:...|....|:||.:...|     :|||. |...:.::        ..:.||.
Frog   930 KKHQERLAQLAREDAEREVREKEEARRKKELLEKMEKARNE-PVNDSDMVDKMFGFLGTTSSLPG 993

  Fly   944 RPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNI 1008
            :...|.|....:....|.::.|               :.|.|              ||.......
Frog   994 QEGQAPTGFEDLERPQGEMEEE---------------DLDGA--------------LPLPEEEEE 1029

  Fly  1009 DTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSP 1073
            |.|::.:.|:|||||.|..|..:.|:|||:.||.||...|::|:.|:|:||||||||||:    |
Frog  1030 DLSEYKFAKFAATYFQGTTTNTYIRRPLKQPLLYHEDEGDQLAALAVWITILRFMGDLPE----P 1090

  Fly  1074 TLHVFDNEN-----LMSDLASLLNTSDSYKPRLFVRQSQ-------------------------- 1107
            ..|...:..     :|:.:...|. ..:||..|...|.:
Frog  1091 KYHTAMSNGSEKIPVMTKIYETLG-KKTYKRELQALQGEGESTQIDGYKKNSVRHKLVSLTLKKK 1154

  Fly  1108 ----RRIPKPLASGEKEAQ-----EFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQ 1163
                ..:.|.|..||...|     |      :.|||:|||:|||||:||::.:|||||..||.||
Frog  1155 SKITEEVTKRLHDGESTLQGNSMLE------DRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQ 1213

  Fly  1164 LYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQ 1228
            |..|||:||::|||:|:|||:.||.||::|..:||:|:..|... .|....:||.||..||.|.|
Frog  1214 LTQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISGGPPG-YAPYCEERLRRTFANGTRTQ 1277

  Fly  1229 PPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNG 1293
            |||..||.|.:.:.|:.|.:..|||..:.|..|:|:||:|..|.|...:.|.|.|||.|.::|..
Frog  1278 PPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNSLADKISLKDRFGFSLYIALFD 1342

  Fly  1294 KLMPLGAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQIL 1351
            |:..||:|.:||:||:|:|||       ::.:|||:|:.|||:|..|:||:.|..||.|||:||:
Frog  1343 KVSSLGSGSDHVMDAVSQCEQYAKEQGAQERNAPWRLFFRKEIFTPWHDPTEDNVATNLIYQQIV 1407

  Fly  1352 NGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIA 1416
            .|:|.|||||..|:|:|.:.:...:|:||...|:....:.|.:::|...:.|.:. :|.|::.|.
Frog  1408 RGVKFGEYRCDKEEDLAELASQQYYVDYGSELIMERLLNLIPSYIPDREITPSKN-VEKWAQFII 1471

  Fly  1417 ATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINS 1481
            |.::|..|.::..:      .::.||::..||...||:..||.:|..:..||.|..:::::.:|.
Frog  1472 AAHKKGIYAQKRSD------SQKVKENVVDFARFKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNW 1530

  Fly  1482 AGLFLIDETEQVLASCCFSEVLKVHVESDDKLH-----VMTFQHVNFVLQCSSAQDANEVINYML 1541
            .|::.:||.||||....|.|:..|......|:.     :.|.:...:....::|:|..:::...|
Frog  1531 TGVYFVDEQEQVLLELSFPEITAVSSSRGGKMQGQSFTMATIKGDEYTFTSNNAEDIRDLVVTFL 1595

  Fly  1542 DNLRQRSSYGVAL--DPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQW-- 1602
            :.||:||.|.|||  :|...|:....|....||||..:.. ||..:|            |..|
Frog  1596 EGLRKRSKYVVALQDNPNPVGEDSGFLSFQKGDLILLDHD-TGETIM------------NSGWAH 1647

  Fly  1603 ---------GQFLAGNVRVLATLTKPS-----------EKLQDILREGRFQEPPKPTPRANYSRR 1647
                     |.|....|.|:.|:||||           ::.||::|..:.      .|.....:.
Frog  1648 GYNERTKHKGDFPTEIVYVMPTVTKPSGEVVALVTMTPDQKQDVVRAVQL------NPSEQEEKM 1706

  Fly  1648 RQHNISQLAESHFREP-----------LDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMH 1701
            :.:.:.:.:..:||.|           .:..|..|..::.||:|..|||.|:....:.|:|.:..
Frog  1707 KPYTLEEFSYDYFRPPPKHTLSRVMITKNRGKDKLWSYTREPIKQALLKKVLMSDEMSQEACMAF 1771

  Fly  1702 HHILKYMGDIARSNL-PVN--TDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYL 1763
            ..|||||||.....: .||  ||.||:.||:...|.||:|||::|||:||....||::||:||:|
Frog  1772 IAILKYMGDYPSKRMRSVNELTDQIFEGALKGEPLKDEIYCQVLKQLTDNHIKYSEEKGWELLWL 1836

  Fly  1764 ATGLVAPSVLVMRELIILLRMRAD-ALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYH 1827
            .|||..||.:::..:...::.|.. |||..|:.||:|:|..|.||..|||:|||.||.:...|:|
Frog  1837 ITGLFPPSNVLLPHIQRFIQSRKQHALATDCMHRLQRALRNGSRKYPPHLVEVEAIQHKTTQIFH 1901

  Fly  1828 KIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQL 1892
            |:||||||.||||:||.|:..:...|||.||.|||..|:|:|:|..|:|.::||.:|.|||:..|
Frog  1902 KVYFPDDTDEAFEVESSTKAKDFCQDIANRLLLKSAEGFSLFVKISDKVISVPEGDFFFDFVRHL 1966

  Fly  1893 IYWLRQQRTIRSISDG-----QYQLHFMRKLWLNNHPGEDLNGDMIFSYPQELHKYLKGYYPIDC 1952
            ..|:::.|..:   ||     .||:.||:|||....||:|...|.||.|.|||.|||:||:....
Frog  1967 TDWIKKARPSK---DGIVPSLTYQVFFMKKLWTTTVPGKDSMADSIFHYYQELPKYLRGYHKCTR 2028

  Fly  1953 EQASRLAILVYSA---DHDVSLQRLPEVLTRLIPEDLIPLQTVAEWRQQILPKVHRDHL--TEDH 2012
            |...:||.|:|..   |.......:|::|..|:|:|||......||::.|:...:: |.  |.:.
Frog  2029 EDVLQLAALIYRVKFEDDKSYFPNIPKMLKELVPQDLIRQLNPDEWKRSIIAYFNK-HAGKTREE 2092

  Fly  2013 AKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIW 2077
            :|:.||:.:..:..|||.||.|||..:...||.||||||..|..::||.||:||.::.::::..|
Frog  2093 SKVAFLKLIYKWPTFGSAFFEVKQTTEPHFPEILLIAINKHGVSLIDPKTKDILATHPFTKISNW 2157

  Fly  2078 SSGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYV 2115
            |||..:|||..||::..|||||.|:.||||||||.||:
Frog  2158 SSGNTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYI 2195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	404/687 (59%)
		MYSc_Myo7	81..726	CDD:276832	386/657 (59%)
		IQ	765..785	CDD:197470	9/19 (47%)
		DUF4355	827..>887	CDD:290964	21/72 (29%)
		MyTH4	1031..1239	CDD:295320	95/247 (38%)
		B41	1248..1429	CDD:214604	72/187 (39%)
		FERM_N	1248..>1288	CDD:286467	16/39 (41%)
		FERM_B-lobe	1342..1429	CDD:271216	30/86 (35%)
		PH-like	1454..1547	CDD:302622	24/97 (25%)
		MyTH4	1674..1819	CDD:214535	65/148 (44%)
		B41	1827..2032	CDD:214604	86/214 (40%)
		FERM_N	1829..>1877	CDD:286467	26/47 (55%)
		FERM_M	1936..2032	CDD:278785	33/100 (33%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	47/88 (53%)
myo7a	XP_004912319.1	MYSc	89..776	CDD:214580	404/688 (59%)
		MYSc_Myo7	108..764	CDD:276832	386/657 (59%)
		IQ	801..822	CDD:197470	9/20 (45%)
		CCDC66	<883..970	CDD:291889	29/99 (29%)
		MyTH4	1052..1288	CDD:214535	95/247 (38%)
		B41	1294..1509	CDD:214604	81/221 (37%)
		FERM_N	1297..>1336	CDD:286467	16/38 (42%)
		FERM_B-lobe	1398..1498	CDD:271216	33/106 (31%)
		FERM_C1_MyoVII	1503..1601	CDD:270019	24/97 (25%)
		SH3	1602..1666	CDD:302595	20/76 (26%)
		MyTH4	1744..1893	CDD:214535	65/148 (44%)
		B41	1900..2112	CDD:214604	86/215 (40%)
		FERM_M	2010..2112	CDD:278785	34/102 (33%)
		FERM_C2_MyoVII	2108..2203	CDD:270020	47/88 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D21221at33208
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13140
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110