Protein Alignment Myo28B1 and myo9aa

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_068078215.1
• Gene: myo9aa / 100006612
• ZFINID: ZDB-GENE-080424-5
• Length: 2584
• Species: Danio rerio
• Alignment Length: 2463
• Identity: 585/2463 - (23%)
• Similarity: 911/2463 - (36%)
• Gaps: 831/2463 - (33%)

  Fly    47 NKQFWVPAGDVLKAMHITS------QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLV 105
            |.|.|:...:..:.|....      .:|.:|:..|.||.|.|:|.||::|:.::.||||.||:|:
Zfish   121 NLQMWLQVTEERRRMVERGFLPQPLPKDFDDLCNLPDLNEKTLLDNLRSRFKQEKIYTYVGSILI 185

  Fly   106 AINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTEST 170
            .|||::.||||..:.:::|.|..|.:|.|||:|::|.|:..:.:.::|||:|||||||:|||:||
Zfish   186 VINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQSRQNQCIVISGESGSGKTQST 250

  Fly   171 KLILQYLAAIS--GKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGAR 233
            ..::.:|.|:|  |..|.:||.|:.|.|::||||||||..|:|||||||:|::.:...|.::||.
Zfish   251 NFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQESGTVRGAY 315

  Fly   234 IQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQ----------- 287
            :::|||||||:|:|..:|||||:||.:|||  |:|.||.....:.|.:||||.|
Zfish   316 VEKYLLEKSRLVYQEHNERNYHVFYYLLAG--TSEEERTAFHLKKPEEYHYLNQMTKKPHRPHWG 378

  Fly   288 -------GGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANL 345
                   ..|||:.|.....||..::.||:::.|.|.....|.|||:|||||||:|: ..::...
Zfish   379 NYYENEPQDCFTVEGEDLKHDFERLQLAMEMVGFLPTTRKQIFSLLSAILHLGNIRY-KKKIYRD 442

  Fly   346 ATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGI 410
            .:.:|.:...|..|::||.:....|..|||.|.....||.:........|...||:..||||..:
Zfish   443 DSIDICNPEVLPVVSELLEVKEEMLFEALTTRKTVTVGEKLIVPYKLAEAGTVRDSMAKSLYSAL 507

  Fly   411 FVRIVRRINETINKQVD----QPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFK 471
            |..||.|||..:..|.|    ..:.|||||||||||:::||||||.|||:|||.||.:|..||||
Zfish   508 FDWIVFRINHALLNQRDLEESAKILSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFK 572

  Fly   472 MEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRS 536
            :||:||:.|.|.|.:|::.||...:.||..||..|:.|:|||..||:.|:||||:|...||...|
Zfish   573 LEQEEYRAEGITWHNIDYIDNTSCITLISKKPTALLHLLDEECNFPQATNQTLLDKFKRQHEGNS 637

  Fly   537 IYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYL------------ 589
             |::........|.|:||||.|.|....|.|||.|....|:..|::.|.|.::
Zfish   638 -YIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLKSSKNAFICGLIGIDPVATF 701

  Fly   590 --------------------------------------VDIF----------------------- 593
                                                  ||.|
Zfish   702 RWAVLRAYFRAMVAFRDAGKRHVEKRSGHDAAAPAVKSVDSFSFLHHPVHQRSLEILQRCKEEKY 766

  Fly   594 -------------PHEMPMDT-------------------------------------------- 601
                         ||..|..|
Zfish   767 IQHACFSGSPPLSPHWSPSSTPPAHCTHSFFDDSGLTIGLLDGGVNRRNPRTPLSDLQGSNAINQ 831

  Fly   602 ----------------------------------------------------------------- 601
                                                                             
Zfish   832 REGWNGRPGRQNRLSSFGSFSEEEGIFINSTSSKLLERAHGILMRNKNYKMKPSLPKHLLDVKSL 896

  Fly   602 ---------------------AKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNF 645
                                 .||.|::..:|:.||:.||.||.|:.|||::||:.|..|.|..|
Zfish   897 KYLSNLTLQDRITKSLLHLHKKKKPPSISAQFQASLNKLMETLGQSQPYFVKCIRSNSEKLPLRF 961

  Fly   646 DKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVAL 710
            :..|.:|||||:||:||.|||::||.|::.::.|...:.:|:|...  .|.....:.:.:.:|.|
Zfish   962 NDSLVLRQLRYTGMLETVRIRQSGYSIKYTFQDFARHFHVLLPEGS--NQASQEAIRQYLQQVDL 1024

  Fly   711 PADSDRQYGKTKLFLRDEDDASLELQRSQ-----LMLKSIVTIQRGIRRVLFRRYMKRYRE---- 766
            ..:. .|.|:|.:|||:     :|.||.|     .:|..||.:||..|.:|.|:...|.|:
Zfish  1025 TPEG-FQVGRTMVFLRE-----IERQRLQDLLHKEVLSRIVYLQRRFRALLERKNFLRVRQAACQ 1083

  Fly   767 --------------------------AIITVQRYWRGRLQRRKYQVMRQGFHRLGACI------- 798
                                      |::.:|..|||..:||:..:.|:      |.:
Zfish  1084 IQNWWRSCQSLQRDSQLEYDMRVQEGAVVCIQSAWRGFRERRRLLLWRE------ASVLIQRTWR 1142

  Fly   799 ------AAQQLTTKFTMVRCR---------TIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEEL 848
                  ||.|:.|.:...|.|         ||:|||:.||||.|:.|::...:|.|...|...:.
Zfish  1143 LYRQRRAALQIQTAWRRHRARELFLRQRDATIRLQAVGRGYLARQRFRELQKQRLKITHLPNGKA 1207

  Fly   849 LKLAKMKEAEEL-LRLQQLKEQKEREQREQQEKRLQEE-------QRLKAEAAARNALAMAAVQQ 905
            ..|.:..:.|:: |....|::..|.:.|.:|......|       :.::.|.....|.|..:.:.
Zfish  1208 SLLTEEDKLEDMGLDASMLEDSFEEQDRSKQALSSAVEASGAGVLEEMEVEMMEGMAPAQPSPEV 1272

  Fly   906 KRRTKPVKQEAPKAPTL------------QARNSLPPPPTTLIVAAPLPTRPAS----AVTRINT 954
            ..|.:|...|.|...|.            ||:.||    ..|.|.:...|.|:.    ::..::.
Zfish  1273 TIRERPRTLEDPNQRTRAKRESRRMRELEQAKFSL----ELLKVRSTGGTSPSDERRWSMELVSE 1333

  Fly   955 IPESP-GTIDVESSKQM-----VDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVP--NNI--- 1008
            |..:| ||.|.:|||..     :||.|:  :..|.|....|.:         |.|||  :|:
Zfish  1334 IAHTPQGTPDSQSSKGSFELLNIDDYFK--DKAPCAEPEDLGS---------PSSVPDQHNVLPS 1387

  Fly  1009 DTSDFSYLKYAATYFGGGATAQHERKP--LKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVS 1071
            |||....|          :....:.||  ::.||.....|..|.:|..|..| ...:...||.:|
Zfish  1388 DTSTPDIL----------SKPDDQSKPPRMQYSLPTFYTPPSESSSLVIKST-TNSVTPCPDGLS 1441

  Fly  1072 SPTLHVFDNEN------LMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLN 1130
            .|:....::..      :.....:|||.:| .|| |.|:.|..:..:|.:..:......|.
Zfish  1442 KPSKDKKESTRRPMVVVISMQKETLLNEAD-VKP-LEVKDSAAQTSEPPSPAQPSTDSSYV---- 1500

  Fly  1131 VPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEP 1195
                 |||:..:       |..::|              |..:.|.           ...||...
Zfish  1501 -----LEKLEKL-------NEEKEE--------------RQKHQRQ-----------QNEKEMME 1528

  Fly  1196 HLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQV 1260
            .:|          |.|..|:...|.||...|                             .:|:.
Zfish  1529 QIR----------QQTHILEEQRRNLVQNER-----------------------------EKLEK 1554

  Fly  1261 DAASTAR--EAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQRQLD-APWK 1322
            ..|.|.|  |...|...| |.||            :..|:...:.   |..|:...|:.| ||
Zfish  1555 QRAETLRRIEQSRQESSG-GRTD------------RPAPIAQPEP---DLTSQRPAREKDGAP-- 1601

  Fly  1323 LYIRKEMFATWYDPSMDPKATQLIYK----QILNGLKCGEYRCRSEK-------DIAMVCALACF 1376
            |.:|..           ||..|.:.:    ::....:..|.|.|..|       :|:|
Zfish  1602 LILRDR-----------PKDAQNLAEGWAPKLTLESRGDEARSRINKKPSNQNVNISM------- 1648

  Fly  1377 VEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRL--IAATYEKSSYVKEEQNDLLLEAQKR 1439
             ...||.|.         |.|...:|        :|:|  ..|..||:   ...||::.|...|.
Zfish  1649 -SERPGNIF---------FSPKTKIA--------YSKLNKDLANQEKT---PGAQNEVSLLGYKS 1692

  Fly  1440 AKEDICLFAHLSWPMRHSRLFEVVRK-------EGPKLQSDELMLGINSAGLFL--IDETEQVLA 1495
            .|.::....|....|..:|...:.|.       |..:.:.||..|   .||..|  .|..|..:.
Zfish  1693 TKTEVGRPGHKKARMARTRSDFLTRSSSTQGEGESEEEEYDETPL---YAGTPLPKQDSEESAVE 1754

  Fly  1496 SCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEG 1560
            :|        |.:|:             :|..::.:..|.
Zfish  1755 AC--------HSDSE-------------MLTTAAEEQKNR------------------------- 1773

  Fly  1561 DLEDCLVLNPGDLIEF--------EAGVTGAQLMAGNAQD-----------CYRGCVNGQWGQFL 1606
                |..|..|:|.:.        :..|.|.....|.|::           |....:.|.:.:
Zfish  1774 ----CKTLPSGELGKHDTRKNSHGDGRVRGKMRFWGKAKNAEKKSSRERLLCGSDTLEGDYTE-- 1832

  Fly  1607 AGNVRVLATLTKPS--EKLQ-----DILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPL 1664
                   |||....  |:|.     |:..:..|:|..:|:|:.  .|||...||.:|    .||:
Zfish  1833 -------ATLLMEEGVERLSPPHSPDLTLQREFKENKEPSPKV--KRRRSVKISSVA----LEPV 1884

  Fly  1665 D------------SDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLP 1717
            .            ||...::.|        |:|.:..:                   |.......
Zfish  1885 QWQNDALQILTCTSDYKSMNDF--------LMKKITDL-------------------DTEDGKKD 1922

  Fly  1718 VNTDLIFQPALQH-----------PLLCD--------ELYCQLMKQLSDNPSSESEKRGWDLLYL 1763
            ...|::|:.||:.           .|..|        :||. |.:|:.:. :...|:|.|.
Zfish  1923 TMVDVVFKKALKEFRVNIFNSYSTALAMDDGKSIRYKDLYA-LFEQILEK-NMRQEQRDWS---- 1981

  Fly  1764 ATGLVAPSVLVMRELIILLR--MRADALADACLKRLKRSLAQGQRKKAPHLIEVEG--------- 1817
                .:|..:.:....:.|.  |......|:.|.:..:...:.:|||...::|...
Zfish  1982 ----ESPVKVWVNTFKVFLDEFMTEHKPLDSSLGKAPKPDRKKRRKKDTDVVEEHNGHIFKSTQY 2042

  Fly  1818 --------------------IQQRCLHIYH------------KIYFPDDTVEAFEIE-----SHT 1845
                                :.:.|.:..|            |.|.|:.:...|.:|     :..
Zfish  2043 SIPTYCEYCSSLIWMMDKACVCKLCRYACHRKCCQKMTTKCSKKYDPELSSRQFGVELSRLTNDE 2107

  Fly  1846 RGAELIAD-IAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQ--QRTIRSISD 1907
            |...|:.: :...:|:.......|:.|:|.               |..|..|:|  ...:..::.
Zfish  2108 RTVPLVVEKLVNYIEMHGLYTEGIYRKSGS---------------TNKIKELKQGLDTDVNGVNL 2157

  Fly  1908 GQYQLHFMR---KLWLNNHPGEDLNGDMIFSYPQEL---------HKYLKGYYPIDCEQASRLAI 1960
            ..|.::.:.   |.||.:.|    |..|.|...:|.         .:.::|.|.: .:|.||
Zfish  2158 DDYNINVIASVFKQWLRDLP----NPLMTFELYEEFLRAMGLQDKKEVIRGVYSV-IDQLSR--- 2214

  Fly  1961 LVYSADHDVSLQRLPEVLTRL------------------------IPEDLIPLQTVAE 1994
                 .|..:|:||...|.|:                        .|:.:.||::|.:
Zfish  2215 -----THLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRCPDTIDPLRSVQD 2267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	283/884 (32%)
		IQ	765..785	CDD:197470	8/49 (16%)
		Atrophin-1	<820..>946	CDD:460830	32/145 (22%)
		MyTH4	1031..1239	CDD:470587	41/215 (19%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	19/93 (20%)
		B41	1248..1429	CDD:214604	39/196 (20%)
		PH-like	1454..1547	CDD:473070	17/101 (17%)
		MyTH4	1674..1819	CDD:214535	26/194 (13%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	18/116 (16%)
		B41	1827..2032	CDD:214604	40/224 (18%)
		FERM_C2_MyoVII	2028..2121	CDD:270020
myo9aa	XP_068078215.1	RA_Myosin-IXa	16..111	CDD:340736
		MYSc_Myo9	161..1039	CDD:276836	283/884 (32%)
		IQ	1145..1166	CDD:197470	6/20 (30%)
		Activator_LAG-3	<1464..1574	CDD:151935	35/192 (18%)
		C1_Myosin-IXa	2030..2087	CDD:410433	4/56 (7%)
		RhoGAP	2096..2281	CDD:470621	36/200 (18%)