DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ATG26

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_013290.1	Gene:	ATG26 / 850886	SGDID:	S000004179	Length:	1198	Species:	Saccharomyces cerevisiae

Alignment Length:	465	Identity:	114/465 - (24%)
Similarity:	177/465 - (38%)	Gaps:	126/465 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHLIVVPMKEEQERIMEDQMTEM 89
            ||.:..|...:..::::.|.|:|.||.|.:       :||.:....|     |...|   |..|:
Yeast   743 GLLTIGSRGDVQPYIALGKGLIKEGHQVVI-------ITHSEFRDFV-----ESHGI---QFEEI 792

  Fly    90 AGQKNSLVSTMYRLLTSMDVMINAQA--------ELLSDPRFQRIYETKFDLMI------LGYFI 140
            ||....|:|.|.. ..||:|.:..:|        :.|....::.....|||::|      :|..|
Yeast   793 AGNPVELMSLMVE-NESMNVKMLREASSKFRGWIDALLQTSWEVCNRRKFDILIESPSAMVGIHI 856

  Fly   141 NDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGTVATQPMGFL----KR--TEN 199
            .:                  :..:|....:|        :|...|.| .|..|:    ||  ..|
Yeast   857 TE------------------ALQIPYFRAFT--------MPWTRTRA-YPHAFIVPDQKRGGNYN 894

  Fly   200 ALKSLLFEFIF------VVFDYKL-------TRIYNDVFPEQDMPTLKELRKNISMAFVGSHLIS 251
            .|..:|||.:|      .|..:::       |.::  :..:.::|.|..:...|   |..|...|
Yeast   895 YLTHVLFENVFWKGISGQVNKWRVETLGLGKTNLF--LLQQNNVPFLYNVSPTI---FPPSIDFS 954

  Fly   252 EGPIRPLVPALIEIGGIQVKD-----KPDPLPKDIDQFISNAK---QGAVFLSLG----SNVKSS 304
            |         .:.:.|....|     ||   |.::.:|||.|:   :..|::..|    ||.|..
Yeast   955 E---------WVRVTGYWFLDDKSTFKP---PAELQEFISEARSKGKKLVYIGFGSIVVSNAKEM 1007

  Fly   305 T-------VRPEIVQIIFKVLSE-LKENVIWKWE-DLENTPGNSSNILYKNWL-PQDDILAHPNT 359
            |       :..::..|:.|..|| |.:....|.| ||.....|..|:.: :|| ||.|...|
Yeast  1008 TEALVEAVMEADVYCILNKGWSERLGDKAAKKTEVDLPRNILNIGNVPH-DWLFPQVDAAVH--- 1068

  Fly   360 KLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVL 424
                 |.|.|....:...|:|.|..|.||||...|..:|..|.|:||..|:  ..:|.||||...
Yeast  1069 -----HGGSGTTGASLRAGLPTVIKPFFGDQFFYAGRVEDIGVGIALKKLN--AQTLADALKVAT 1126

  Fly   425 ENQKYKQAIG 434
            .|:..|...|
Yeast  1127 TNKIMKDRAG 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	114/465 (25%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	111/457 (24%)
ATG26	NP_013290.1	GRAM	194..>239	CDD:214725
		PH-GRAM1_AGT26	219..335	CDD:275402
		PH-GRAM2_AGT26	581..673	CDD:275403
		YjiC	739..1168	CDD:224732	114/465 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950