Protein Alignment Ugt37C2 and UGT2B10

DIOPT Version :9

• Sequence 1: NP_001260516.1
• Gene: Ugt37C2 / 53513
• FlyBaseID: FBgn0040262
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 150/531 - (28%)
• Similarity: 271/531 - (51%)
• Gaps: 66/531 - (12%)

  Fly    27 FSSHSPSHLII----------HMSVAKALVKAGHNVTVV-------------SMLKPKV-----T 63
            |||.|...:::          ..::.|.||:.||.|||:             |.||.:|     |
Human    17 FSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSASILFDPNDSSTLKLEVYPTSLT 81

  Fly    64 HKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPR-FQRIY 127
            ..:...|::.:.:....|.:|.......|:..:      |....|::.|...:::|:.: .:::.
Human    82 KTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEI------LWAINDIIRNFCKDVVSNKKLMKKLQ 140

  Fly   128 ETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGN---PSELSYVPLMGTVATQ 189
            |::||::....::...:| :|....:|.:.:...:|..:.::::|.   |.  ||||::.:..:.
Human   141 ESRFDIVFADAYLPCGEL-LAELFNIPFVYSHSFSPGYSFERHSGGFIFPP--SYVPVVMSKLSD 202

  Fly   190 PMGFLKRTENALKSLLFEFIFVVFDY-KLTRIYNDVFPEQDMPTLKELRKNISMAFVGSHLISEG 253
            .|.|::|.:|.|..|.|:|.|.:|:. |..:.|::|....  .||.|..:...:..:.:....:.
Human   203 QMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLGRP--TTLSETMRKADIWLMRNSWNFKF 265

  Fly   254 PIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKV 317
            | .|.:|.:..:||:..| ...||||::::|: |:.:.|.|..||||.|.:.|  .|...:|...
Human   266 P-HPFLPNVDFVGGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNMT--EERANVIATA 326

  Fly   318 LSELKENVIWKWEDLENTPGNSSNI------LYKNWLPQDDILAHPNTKLFITHAGKGGITEAQY 376
            |:::.:.|:|:::      ||..:.      ||| |:||:|:|.||.|:.||||.|..||.||.|
Human   327 LAKIPQKVLWRFD------GNKPDALGLNTRLYK-WIPQNDLLGHPKTRAFITHGGANGIYEAIY 384

  Fly   377 HGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYR 441
            ||:|||.:|:|.|||.|.|.|:..|..:.:|..:::...|.:|||.|:.:..||:.|.:.|.:..
Human   385 HGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQH 449

  Fly   442 DRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDI--YALIVTILVLFVLLTRLVAK 504
            |:|:......|||.|:::||:||.:|:..:.::.:.|.::||:  :.|.....|||: :|:....
Human   450 DQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATVLFI-ITKCCLF 513

  Fly   505 IVWNKFGGKAK 515
            ..| ||..|.|
Human   514 CFW-KFARKGK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	136/479 (28%)
		UDPGT	33..515	CDD:278624	145/523 (28%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	146/525 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.690