DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	530	Identity:	151/530 - (28%)
Similarity:	263/530 - (49%)	Gaps:	78/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKP------KVTHKDIHL 69
            ||.|::.|.|..:| :|.... ||.:....:.:.|.:.|||||||   :|      |........
Zfish    12 LLCVLSGTYGGKVL-VFPLDG-SHWVNMKVLIEELHRKGHNVTVV---RPSNSWYIKEESPFYSS 71

  Fly    70 IVVP----MKEEQERIMEDQMTE-------MAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPR- 122
            |.:|    ..||...::.:::.|       :..:.......|.:..|..:.|:.....:|.|.:
Zfish    72 ITIPNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMDRMLEDEKV 136

  Fly   123 FQRIYETKFDLMILGYFINDFQLG----VAHKLKVPVIIN--WMSAPVPAIDKYTGNPSELSYVP 181
            ...|.:.|||:::.     |..:|    :|:|..:|::.|  |   .:.....:...||.|||:|
Zfish   137 MNSIQDAKFDVVLA-----DPAVGGGPILAYKFNIPLVFNVRW---TIQGEGHFAIAPSPLSYIP 193

  Fly   182 LMGTVATQPMGFLKRTENAL--------KSLLFEFIFVVFDYK-----LTRIYNDVFPEQDMPTL 233
            :.|...|..|.||:|.:|.|        ..::.|.|:..|.:|     :|  |..:|.:.|   :
Zfish   194 VPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFGPNVT--YFSLFQDAD---I 253

  Fly   234 KELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSL 297
            ..:|.:.:..|.          ||.:|.::.:.|.|.| ...|||.|:::|: |:.:.|.:.:||
Zfish   254 WLMRNDFTFEFP----------RPTMPNIVYMSGFQCK-PAKPLPNDLEKFVESSGEHGVIVMSL 307

  Fly   298 GSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLEN-TPGNSSNILYKNWLPQDDILAHPNTKL 361
            |:.:  :.:..::...|....:||.:.|||::..... |.||  |.|...||||:|:|.||..|:
Zfish   308 GTLI--AQLPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGN--NTLLVEWLPQNDLLGHPQIKV 368

  Fly   362 FITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLEN 426
            |:.|.|..||.||.|||||::.||:..|||.|...||..|....:|:.::.:....:||||||.|
Zfish   369 FVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYN 433

  Fly   427 QKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTI 491
            ..|::.:.:.|.|:.|:|:......:||.|:::|::|||:|::.|..|::|:.:::|:   |:|:
Zfish   434 PSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDV---ILTL 495

  Fly   492 LV---LFVLL 498
            :|   :|.|:
Zfish   496 MVTGFVFALM 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	141/494 (29%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	144/508 (28%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	146/520 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740