DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	513	Identity:	142/513 - (27%)
Similarity:	256/513 - (49%)	Gaps:	70/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHLIIHMSVAKALVKAGHNVTVVS-----MLKPKVTHKDIHLIVVPM-KEEQERIMEDQMTEMAG 91
            ||.:....:.|||...||::.|:.     .:|.|..:  .:.|.:|. |...|..::|.::::..
Zfish    38 SHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEKSDY--YNSITIPQSKGMDEEFVDDMISKVIN 100

  Fly    92 Q---KNSLVST-------------MYRLLTSMDVMINAQAELLSDPRFQRIYETKFDLMI----- 135
            .   |:|.:||             |.:::..:...|....|:|     :.:.|.::|||:
Zfish   101 HERGKSSWLSTVKLFFDSVIDNYEMTKMVCDITTSIFESEEIL-----KTLQEKQYDLMLTDPVW 160

  Fly   136 -LGYFINDFQLGVAHKLKVPVIIN--WMSAPVPAID-KYTGNPSELSYVPLMGTVATQPMGFLKR 196
             :|..:       |||||:|::.|  |.:    .:| .:...||.:||:|:.|:..|..|.|.:|
Zfish   161 GMGIIL-------AHKLKLPMVYNVRWTT----TVDGHFNIAPSPMSYIPITGSGNTDRMSFFQR 214

  Fly   197 TENALKSLLFEFIFVVFDYKLTRI----YNDVFPEQDMPTLK--ELRKNISMAFVGSHLISEGPI 255
                :|:::|.|   ..|.|.:|.    |..:..:...|.:.  :|.:...:..:....:.|.|
Zfish   215 ----VKNIIFYF---TNDIKYSRFSLPQYQAICDKYFDPPVDFYQLLQGADIWLMRVDFVFEFP- 271

  Fly   256 RPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLS 319
            ||.:|.:|..||.|. ....|||.|::.|: |:...|.:.:|||:.:  |.:..::...|....:
Zfish   272 RPTMPNIIYTGGFQC-TPAKPLPHDLEDFMQSSGDHGVIVMSLGTFI--SALPEDVTAEIAAAFA 333

  Fly   320 ELKENVIWKWEDLE-NTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVA 383
            .|.:.|||::...: :|.||  |.|..:|:||.|:|.||.||:|:.|.|..|:.||.|||||:|.
Zfish   334 RLPQKVIWRYTGKKPSTLGN--NTLLVDWMPQKDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVG 396

  Fly   384 LPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAK 448
            :|.|.||..|...::..|....:.|..:.|:||..|:|||:.|..|:..:.:.|.|:.|:|:...
Zfish   397 IPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPL 461

  Fly   449 QSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAKIV 506
            .|.:||.|:::||:||.:|::.|..|.:...:::|:...::.::::|:.....|.:.|
Zfish   462 DSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVAVTLIAVVLIFIFSIFYVVRYV 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	135/472 (29%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	142/513 (28%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	142/513 (28%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	83/245 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740