DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	522	Identity:	153/522 - (29%)
Similarity:	255/522 - (48%)	Gaps:	58/522 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTV-VSMLKPKVTHKDIHLIVV 72
            |:|:.:.:.|...|:|.|...:  ||.....:|...|:...|.||| |....|.:..
Zfish    11 LVLIFIFSFTHAGNVLVLPGEY--SHWQNMRNVVDELLNRNHTVTVLVCSASPTINF-------- 65

  Fly    73 PMKEEQER----IMEDQMT--EMAGQKNSLVS---------------TMYRLLTSMDVMINAQAE 116
               .:|||    :.|..::  |:.|....|:.               .:..||..:.||..|..:
Zfish    66 ---TQQERFQYLVFEVPLSAQELDGASEELIHIWTQHPSPNRLQTALQIIELLGRVRVMHRAMCD 127

  Fly   117 --LLSDPRFQRIYETKFDLMILGYFIND--FQLG--VAHKLKVPVIINWMSAPVPAIDKYTGN-P 174
              |.:|....::...|||::     .||  |...  :|..|.:|::::...:|...:::..|. |
Zfish   128 SMLRNDALIAQLSALKFDVL-----FNDPMFMCADLLAEMLGLPLVLSVRISPGFCLERMCGQMP 187

  Fly   175 SELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDY-KLTRIYNDVFPEQDMPTLKELRK 238
            :..|:||:..||.|..|.|::|.:|.:.:::|...|.:..: .|...|.||..:.  .|:.|...
Zfish   188 APPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVAWISLDSYYTDVLGKP--TTMCETMG 250

  Fly   239 NISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVK 302
            ...:..:.::...|.| ||..|....:||:..| ...||.|::::|: |:...|.|..||||.:|
Zfish   251 KADIWLIRTYWDFEYP-RPFPPNFKFVGGLHCK-PAKPLSKEMEEFVQSSGDHGVVVFSLGSMIK 313

  Fly   303 SSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGN-SSNILYKNWLPQDDILAHPNTKLFITHA 366
            :.|  .|....|...|.::.:.|:|::..  .||.. :.|....:|:||:|:|.||.||.||||.
Zfish   314 NLT--SERANTIAAALGQIPQKVVWRYSG--KTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHG 374

  Fly   367 GKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQ 431
            |..|:.||.|||||||.||:|.|||.|...|:..|..:.||:.::....|.||||.||.|..||:
Zfish   375 GTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKE 439

  Fly   432 AIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFV 496
            :|.:.|.::.|:||......|:|.|:::|::||.:|:..:..:::.|.:.||:.|.:::|..|..
Zfish   440 SIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAALIT 504

  Fly   497 LL 498
            .|
Zfish   505 FL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	145/489 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	147/498 (30%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	150/510 (29%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	86/236 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810