DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt8

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	534	Identity:	146/534 - (27%)
Similarity:	255/534 - (47%)	Gaps:	61/534 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVFLLLLGVVAS--TQGANILGLFSSHSPSHLIIHMSVAKALVKAGHN-VTVVSMLK--PKVTHK 65
            ||...||..:|:  :..|.|:.:......|||.|..::|.||...||: |.:||..:  |...|.
Zfish     5 FVLATLLWCLATSLSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHDTVFLVSEGREIPPSNHY 69

  Fly    66 DIHLIVVPMKEEQERIMEDQMTE--MAGQKNSLVSTMYRLLTSMDVM----INAQAELLSDPRFQ 124
            .:        :....|......:  :..:..::.|.....|...|::    .|..|.:.|....:
Zfish    70 RL--------QRYPGIFNSTSADDFLQSKVRNIFSGRLTALELFDILDHYSQNCDAVVGSTSVME 126

  Fly   125 RIYETKFDLMIL------GYFINDFQLGVAHKLKVPVII----NWMSAPVPAIDKYTGNPSELSY 179
            ::....|||:::      |:.|       ||.|.|...:    .|..|.|       |.|:.|||
Zfish   127 QLKREHFDLLLVDPNEMCGFVI-------AHILGVQYAVFSTGLWYPAEV-------GAPAPLSY 177

  Fly   180 VPLMGTVATQPMGFLKRTENALKSLLFEF---IFVVFDY-KLTRIYNDVFPEQDMPTLKELRKNI 240
            ||...::.|..|...:|..|....|:..|   ..|:..| ::.|.||    .|...::.:|.:|.
Zfish   178 VPEFNSLLTDHMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRKYN----IQPSVSMHDLVQNS 238

  Fly   241 SMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNA-KQGAVFLSLGSNVKSS 304
            .:..:.:.:..|.| ||.:|.::.:|||..| .|.|||::.:.::.:. :.|.|.:|.|:.||
Zfish   239 RLWMLCTDMALEFP-RPTLPHVVYVGGILTK-PPSPLPQEFETWVKDTDEDGFVVVSFGAGVK-- 299

  Fly   305 TVRPEIVQIIFKVLSELKENVIWKWEDL-ENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGK 368
            .:..:|.|.:...||.|.:.|||::..: .:..||::.::  :|:||:|:|...||:.|::|.|.
Zfish   300 YLSDDIAQKLAGALSRLPQRVIWRFSGVPPSNLGNNTKLV--DWMPQNDLLGQTNTRAFLSHGGL 362

  Fly   369 GGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAI 433
            ..|.||.|||||:|.:|:|||.......::..|.|:.|:...::|:.|..|:..|:.:::|::..
Zfish   363 NSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERA 427

  Fly   434 GQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALI-VTILVLFVL 497
            ...|.:::|:|.......|:|..|||||:||.:|:|....:...|...||:..:| |.:|:....
Zfish   428 QLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDVAMVIGVCLLLTGYC 492

  Fly   498 LTRLVAKIVWNKFG 511
            |.|:| |.:..:.|
Zfish   493 LYRIV-KFIQFRLG 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	133/487 (27%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	139/505 (28%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	140/510 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740