Protein Alignment Ugt37C2 and UGT1A1

DIOPT Version :9

• Sequence 1: NP_001260516.1
• Gene: Ugt37C2 / 53513
• FlyBaseID: FBgn0040262
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 150/542 - (27%)
• Similarity: 273/542 - (50%)
• Gaps: 50/542 - (9%)

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSP---SHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIH 68
            :.|.:||.|.|..|..:|      .|   ||.:..:...:.|.:.||.:.|::        .|..
Human    15 LLLCVLGPVVSHAGKILL------IPVDGSHWLSMLGAIQQLQQRGHEIVVLA--------PDAS 65

  Fly    69 LIV----------VPMKEEQERIMED------QMTEMAGQKNSLVSTMYRLLTSMDVMINAQAEL 117
            |.:          .|:..::|.:.|.      .:.|.......::.|..::.....::::..:.|
Human    66 LYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHL 130

  Fly   118 LSDPRFQ-RIYETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVP 181
            |.:.... .:.|:.||:|:...|:....: ||..|.:|.:....:.|.....:.|..|:..||||
Human   131 LHNKELMASLAESSFDVMLTDPFLPCSPI-VAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVP 194

  Fly   182 LMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISMAFVG 246
            ...:..:..|.||:|.:|.|.:....|:..|. |.........|.:::: |:::|..:.|:....
Human   195 RPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVV-YSPYATLASEFLQREV-TVQDLLSSASVWLFR 257

  Fly   247 SHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPEI 310
            |..:.:.| ||::|.::.:|||....: :||.::.:.:| ::.:.|.|..||||.|  |.:..:.
Human   258 SDFVKDYP-RPIMPNMVFVGGINCLHQ-NPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKK 318

  Fly   311 VQIIFKVLSELKENVIWKWEDLENTPGNSSN--ILYKNWLPQDDILAHPNTKLFITHAGKGGITE 373
            ...|...|.::.:.|:|::..  ..|.|.:|  ||.| ||||:|:|.||.|:.||||||..|:.|
Human   319 AMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVK-WLPQNDLLGHPMTRAFITHAGSHGVYE 380

  Fly   374 AQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFST 438
            :..:|||||.:|:||||..||..||..|.|:.|::|.:|.:.|.:|||.|:.::.||:.|.:.|:
Human   381 SICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSS 445

  Fly   439 LYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVH-MNFIQLNNLDIYALIVTILVLFVLLTRLV 502
            |::|||:......|||.|:::||:|||:|: |:.| :.:.|.::||:...::.:::....:|...
Human   446 LHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKC 509

  Fly   503 AKIVWNK-FGGKAKISQTKKKQ 523
            ....:.| .|.|.::.:..|.:
Human   510 CAYGYRKCLGKKGRVKKAHKSK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	139/482 (29%)
		UDPGT	33..515	CDD:278624	141/503 (28%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	144/520 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740