Protein Alignment Ugt37C2 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001260516.1
• Gene: Ugt37C2 / 53513
• FlyBaseID: FBgn0040262
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 151/543 - (27%)
• Similarity: 273/543 - (50%)
• Gaps: 55/543 - (10%)

  Fly     9 LLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHLIVVP 73
            ||||.|....:...:|.:  ....||.:......:.|...||.|.|:::        ::::.:
Human    17 LLLLSVQPWAESGKVLVV--PTDGSHWLSMREALRDLHARGHQVVVLTL--------EVNMYI-- 69

  Fly    74 MKEEQERIM--------EDQMTE-MAGQKNSLVSTMYRL---------LTSMDVMINAQ-AELL- 118
             |||....:        :|:... :.|...|...|.:.|         :.:|.::|:.. .|||
Human    70 -KEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLH 133

  Fly   119 SDPRFQRIYETKFDLMILGYFINDFQL---GVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYV 180
            ::...:.::.|.||:::    .:.|.|   .:|..|.:|.:....:.|.....|.|..|:..||:
Human   134 NEALIRHLHATSFDVVL----TDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSYI 194

  Fly   181 PLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISMAFV 245
            |.:.|..:..|.||:|.:|.|..|...::..........:.:::|  |...::.:|..:.|:...
Human   195 PRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELF--QREVSVVDLVSHASVWLF 257

  Fly   246 GSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPE 309
            ....:.:.| ||::|.::.||||...: ..||.::.:.:| ::.:.|.|..||||.|  |.:..:
Human   258 RGDFVMDYP-RPIMPNMVFIGGINCAN-GKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEK 318

  Fly   310 IVQIIFKVLSELKENVIWKWEDLENTPGNSSN--ILYKNWLPQDDILAHPNTKLFITHAGKGGIT 372
            ....|...|.::.:.|:|::..  ..|.|.:|  ||.| ||||:|:|.||.|:.||||||..|:.
Human   319 KAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVK-WLPQNDLLGHPMTRAFITHAGSHGVY 380

  Fly   373 EAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFS 437
            |:..:|||||.:|:||||..||..||..|.|:.|::|.:|.:.|.:|||.|:.::.||:.|.:.|
Human   381 ESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLS 445

  Fly   438 TLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVH-MNFIQLNNLDIYALIVTILVLFVLLTRL 501
            :|::|||:......|||.|:::||:|||:|: |:.| :.:.|.::||:...::.:::....:|..
Human   446 SLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK 509

  Fly   502 VAKIVWNK-FGGKAKISQTKKKQ 523
            .....:.| .|.|.::.:..|.:
Human   510 CCAYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	140/483 (29%)
		UDPGT	33..515	CDD:278624	144/509 (28%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	145/522 (28%)
		egt	<262..508	CDD:223071	93/253 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840