Protein Alignment Ugt37C2 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_001260516.1
• Gene: Ugt37C2 / 53513
• FlyBaseID: FBgn0040262
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 151/514 - (29%)
• Similarity: 267/514 - (51%)
• Gaps: 44/514 - (8%)

  Fly    33 SHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHLIVVPMK--------EEQERIMEDQMTEM 89
            ||.....||.:.|:..||.|.||   .|:|:.:....:...:|        |:|:|   :.|...
Human    36 SHWFTMQSVVEKLILRGHEVVVV---MPEVSWQLGRSLNCTVKTYSTSYTLEDQDR---EFMVFA 94

  Fly    90 AGQKNSLVSTMYRLLTS-----MDVMINAQAELLSDPRF-QRIYETKFDLMILGYFINDFQ---L 145
            ..:..:.:.:.:.||||     .|:..:....|.:|.:. :.:.|:.||.:    |::.|.   |
Human    95 DARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAV----FLDPFDACGL 155

  Fly   146 GVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIF 210
            .||....:|.::.........:::....|:.|||||.:....:..|.|.:|..|.:.. |.|.:|
Human   156 IVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMH-LEEHLF 219

  Fly   211 VVFDYK-LTRIYNDVFPEQDMPTLKELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKP 274
            ..:.:| :..|.:::.  |...|..:|..:.|:..:.:..:.|.| :|::|.:|.||||.. .:.
Human   220 CPYFFKNVLEIASEIL--QTPVTAYDLYSHTSIWLLRTDFVLEYP-KPVMPNMIFIGGINC-HQG 280

  Fly   275 DPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGN 338
            .|:|.:.:.:| ::.:.|.|..||||.|  |.:..:....|...|.::.:.|:|::..  ..|.|
Human   281 KPVPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG--TRPSN 341

  Fly   339 SSN--ILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSG 401
            .:|  ||.| ||||:|:|.||.|:.||||||..|:.|:..:|||||.:|:||||..||..||..|
Human   342 LANNTILVK-WLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKG 405

  Fly   402 YGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPN 466
            .|:.|::|.:|.:.|.:|||.|:.::.||:.|.:.|:|::|||:......|||.|:::||:|||:
Human   406 AGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPH 470

  Fly   467 LQSPSVH-MNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVWNK-FGGKAKISQTKKKQ 523
            |: |:.| :.:.|.::||:...::.:::....:|.......:.| .|.|.::.:..|.:
Human   471 LR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	140/454 (31%)
		UDPGT	33..515	CDD:278624	150/504 (30%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	150/505 (30%)
		egt	<264..504	CDD:223071	92/246 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740