Protein Alignment Ugt37C2 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_652629.1
• Gene: Ugt37C2 / 53513
• FlyBaseID: FBgn0040262
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 155/517 - (29%)
• Similarity: 266/517 - (51%)
• Gaps: 60/517 - (11%)

  Fly    33 SHLIIHMSVAKALVKAGHNVTVV----SMLKPKVTHKDIHLIVVP---MKEEQERIMEDQMTEMA 90
            ||.:...::.|.||:.||.|||:    |:|........:.|.|.|   .|.|.|.|:..|:...:
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWS 98

  Fly    91 G-QKNSL---VSTMYRLLTSM-DVMINAQAELLSDPR-FQRIYETKFDLMILGYFINDFQLG--V 147
            . ||:|.   .|....:|... |:..|...:::|:.: .:::.|::||::....|   |..|  :
Human    99 DIQKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAF---FPCGELL 160

  Fly   148 AHKLKVPVIINWMSAPVPAIDKYTGN---PSELSYVPLMGTVATQPMGFLKRTENALKSLLFEFI 209
            |..|.:|.:.:....|...|::::|.   |.  ||:|::.:..:..|.|::|.:|.:..|.|:|.
Human   161 AALLNIPFVYSLCFTPGYTIERHSGGLIFPP--SYIPVVMSKLSDQMTFMERVKNMIYVLYFDFW 223

  Fly   210 FVVFDY-KLTRIYNDVF--PEQDMPTLKE----LRKNISMAFVGSHLISEGPIRPLVPALIEIGG 267
            |.:.|. |..:.|::|.  |.....|:.:    |.:| |.:|...|        |.:|.:..:||
Human   224 FQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRN-SWSFQFPH--------PFLPNIDFVGG 279

  Fly   268 IQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWED 331
            :..| ...||||::::|: |:.:.|.|..||||.:.:.|.  |...:|...|:::.:.|:|:::
Human   280 LHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTA--ERANVIATALAKIPQKVLWRFD- 340

  Fly   332 LENTPGNSSNI------LYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQ 390
                 ||..:.      ||| |:||:|:|..|.|:.||||.|..||.||.|||:|||.:|:|.||
Human   341 -----GNKPDALGLNTRLYK-WIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQ 399

  Fly   391 PGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWT 455
            |.|.|.|:..|..:.||..:::...|.:|||.|:.:..||:.:.:.|.:..|:|:......|||.
Human   400 PDNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWI 464

  Fly   456 EYILRHQGAPNLQSPSVHMNFIQLNNLDI--YALIVTILVLFVLLTRLVAKIVWNKFGGKAK 515
            |:::.|:||.:|:..:..:.:.|.::||:  :.|.....|:|| :|:......| ||..|.|
Human   465 EFVMCHKGAKHLRVAARDLTWFQYHSLDVIGFLLACVATVIFV-VTKFCLFCFW-KFARKGK 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_652629.1	Glycosyltransferase_GTB-type	33..515	CDD:471961	154/515 (30%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	155/517 (30%)