DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt37E1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	262/532 - (49%)
Similarity:	363/532 - (68%)	Gaps:	12/532 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IGVHFVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKV-THK 65
            ||....|||.. :..|:.||||||:|.:|||||:|:||:|.|||...|||:|||:.:|||: ||:
  Fly     7 IGFLIAFLLST-MTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHE 70

  Fly    66 DIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPRFQRIYET- 129
            :|.:|:.|..||::|.:::.|.|::.:|.|...||.:.:......:..|.|.::.|..:.|||.
  Fly    71 NITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIYENP 135

  Fly   130 --KFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMG---TVATQ 189
              ||||:.||...|.:|||:|.|||.||||:|:..|:|.:|...||.::.||||.:.   ....:
  Fly   136 KIKFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGNVNDPSYVPTVNVALNAGQK 200

  Fly   190 PMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFP-EQDMPTLKELRKNISMAFVGSHLISEG 253
            .|.|..|..|..|..:......|.|||:.:.|...|. |.:.|...|:::.:|:.|...|..|||
  Fly   201 TMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFPNYHEMKRRVSLLFYNYHSASEG 265

  Fly   254 PIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVL 318
            ||||.||..|||||||||::.|||||::.:|:..|.:||:|.|||:||.::|.||:.|.|::|||
  Fly   266 PIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGTNVNTNTFRPDTVDILYKVL 330

  Fly   319 SELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVA 383
            |:|.:.||||||||:|.|||:|||.:.|||||||||||||||||||||||||:.|||||||||||
  Fly   331 SKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVA 395

  Fly   384 LPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAK 448
            |||||||.|||.:|.|||:|..||:|::||..|...::|||.|..|::.||:|||||||||:||:
  Fly   396 LPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTAR 460

  Fly   449 QSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVWN---KF 510
            |||::||||:||||||.:||||.:|..|:..||||:|.:::.:.:|.::..:.:.:.:.|   .:
  Fly   461 QSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGY 525

  Fly   511 GGKAKISQTKKK 522
            |.:.|....|.|
  Fly   526 GSQRKAVANKLK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	245/472 (52%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	243/492 (49%)
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	242/468 (52%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	212/420 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445647
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	83	1.000	Inparanoid score	I2351
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm50532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	10.000