DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt2a1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_031759199.1	Gene:	ugt2a1 / 447975	XenbaseID:	XB-GENE-954008	Length:	735	Species:	Xenopus tropicalis

Alignment Length:	554	Identity:	148/554 - (26%)
Similarity:	254/554 - (45%)	Gaps:	67/554 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VHFVFLLLLGVVASTQGANILGLFSSH---------SPSHLIIHMSVAKALVKAGHNVTVV---- 55
            :|::|..||..:          ||..|         ..||.:....:.:.|...||.||.:
Frog   212 IHYLFQDLLFAL----------LFQWHWDEYYSEVLDASHWLNLRLILEELAHKGHEVTALVHSA 266

  Fly    56 SMLKPKVTHKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMY--------RLLTSMDVMIN 112
            :||..       |.:...:|.|...:...:.|.:..|::.....:|        .|...:.|.:.
Frog   267 NMLID-------HNLPSALKAEVFPVAFTKETFLTLQRDFFNFWIYGVHNMSYWELYEHLKVAVA 324

  Fly   113 AQAELLSD---------PRFQRIYETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAID 168
            :..:|..|         ....::...|||:::........:| :|..|.||.:.::..:...:::
Frog   325 SSLKLQRDTCDGVLKNKELMYKLQNQKFDIVVADPVAPCGEL-IAESLGVPFVYSFRFSMGNSLE 388

  Fly   169 KYTGN-PSELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIF-VVFDYKLTRIYNDVF--PEQD 229
            :..|. ||..||||...|..:..|.|.:|..|.:.....:.|| :||.......|:::.  |.:
Frog   389 RLCGQLPSPFSYVPGAMTAFSDKMSFGQRLANTVLYAFQDLIFSLVFQKNWDNYYSEILGRPAK- 452

  Fly   230 MPTLKELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAV 293
               :.|:.....:..:.::...|.| ||::|....:||:... ...|||::|::.: |:.:.|.|
Frog   453 ---VCEIMGKAEIWLIRTYWDFEYP-RPILPNFKFVGGLHCA-PAKPLPEEIEKVVESSGEHGIV 512

  Fly   294 FLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPN 358
            ..|:||.:|:.:  .|...||...||:|.:.|:|::...:......:.|.| :|:||:|:|.||.
Frog   513 VFSMGSMIKNFS--NERTNIIAAALSQLPQKVLWRYSGKKPDALGENTITY-DWIPQNDLLGHPK 574

  Fly   359 TKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEV 423
            ||.||||.|..||.||.|||||:|.:|:|.:||.|...|:..|..:.||...:....|.||:..|
Frog   575 TKAFITHGGTNGIYEAIYHGVPIVGIPLFAEQPDNIVHMKSKGMAIMLDFNKMGTQDLLDAVNTV 639

  Fly   424 LENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALI 488
            :.|..||:...:.|.::.|:|:....|.|||.|:::||:||.:|:..|..:.:.|.:.||:...:
Frog   640 INNPTYKENAMRLSRIHHDQPVKPLDSAVFWIEFVMRHKGAKHLRPASHELTWYQYHCLDVIGFM 704

  Fly   489 VTILVLFVLLTRLVAKIVWNKFGGKAKISQTKKK 522
            ...|.||..:|     |.:..|..|.....||:|
Frog   705 FVCLFLFFYIT-----ITFLTFCYKKCCRTTKEK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	133/497 (27%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	138/507 (27%)
ugt2a1	XP_031759199.1	UDPGT	238..733	CDD:278624	140/516 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000