DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	145/523 - (27%)
Similarity:	253/523 - (48%)	Gaps:	68/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDI----HLIVVPMKEEQE 79
            |.|||||:|.....|...:...:.:.|...|||||:::   |.....||    |:.|..:.|..:
  Fly    22 QAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLIT---PIGMPNDIEGVRHIRVAQLNERIK 83

  Fly    80 RIME-DQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPRFQRIYETK---FDLMI----- 135
            .::| ||:.:.      :::.......:...:.||..::||||..||:...|   |||:|
  Fly    84 EMLESDQVLDF------MINKWTESALTAKALFNASNDILSDPGVQRMLHDKSESFDLIIMEPSS 142

  Fly   136 ------LGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGTVATQPMGFL 194
                  |..|.|...:|::     .:.|||.:.      :..|||:...|.|:      .|:||
  Fly   143 LDALYGLVEFYNATLMGLS-----SIRINWHTY------ELAGNPAPSIYEPI------SPVGF- 189

  Fly   195 KRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQ----------DMPTLKELRKNISMAFVGSHL 249
             ..|.:|.|.::.:|.:: :.||.. |..:.|.|          ....:.|||...|:..:.||
  Fly   190 -SLETSLFSRVYNWIHIM-EEKLVN-YLILRPAQLHLFQKFFGYSAQKMNELRSRFSLMLINSH- 250

  Fly   250 ISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQII 314
            .|.|.:|...|.:||:||:.:.:.|:|..:::.:|:..|..|.::.|:|:::....:...|.:::
  Fly   251 YSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDILIKFLPENIQELL 315

  Fly   315 FKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGV 379
            .:..:.|.|::||| .:|...|..|.|:......||..||.|||.:||||:.|...:.||...||
  Fly   316 LQTFATLNESIIWK-SELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGV 379

  Fly   380 PMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRP 444
            ||:.||:|.||.||...::.||....:|:.|:.:|:|.:.:|.:|.|..|.....:.|..::|||
  Fly   380 PMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRP 444

  Fly   445 MTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYAL--IVTILVLFVLLTRLVAKIVW 507
            |:...:.|:||||.||::....::     :|..::..::.|.:  |:...:.|.|:...:..:|:
  Fly   445 MSPLDTAVWWTEYALRNRNITRMR-----LNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLVY 504

  Fly   508 NKF 510
            ..|
  Fly   505 TLF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	138/476 (29%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	138/509 (27%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	138/471 (29%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	137/504 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445692
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850