DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt49B2

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	171/551 - (31%)
Similarity:	278/551 - (50%)	Gaps:	66/551 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVS-------------- 56
            |:.||.:.::.:..||.||..|.....||.::..::.:.|||.||.||.::
  Fly     4 FMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYR 68

  Fly    57 -MLKPKV-THKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLS 119
             :|.||. |..||..:   ||.:....|.|            :|.:..:..:..:.|.:....|:
  Fly    69 EILLPKYDTWADISAM---MKTKSALDMID------------MSKLTHMRLAQHIGIKSTDFALA 118

  Fly   120 DPRFQR-IY----ETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSY 179
            .|..|. ||    :.||||:::..|.|:..|.:.:..::|.|.....|......:..|..:.|||
  Fly   119 HPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSY 183

  Fly   180 VPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQD-------------MP 231
            ||.:....|..|...:|.||.:.|...:.:..|          ..:|:||             :|
  Fly   184 VPNVFLSCTDRMSLWERLENVVISTAEDVVREV----------SYYPQQDAVIRKHFSSLLPRVP 238

  Fly   232 TLKELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLS 296
            |:|:|.:|||:..:.|::....| ||:...:|.:||:.:. .|.|||:.|..::.||:.||::.|
  Fly   239 TVKQLEQNISVILLNSYMPLTSP-RPMSQNMISVGGLHIL-PPKPLPEHIKNYLDNAEHGAIYFS 301

  Fly   297 LGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKL 361
            |||.|:|:.:..|.:||...|.:.||:.|:||:|| :..|....|:..:.||||.|||||||.|:
  Fly   302 LGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFED-DQLPNLPDNVKVEKWLPQADILAHPNVKV 365

  Fly   362 FITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLEN 426
            ||.|.|..|:.||.||.||::.:|.:.||..|....:.:||.:.||..:|::|.|:.||..:|::
  Fly   366 FIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKD 430

  Fly   427 QKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTI 491
            .||:..:.:.|.::||||:.|..:.::|..|::.|:|||:|.:..||:.:.|...||:.|:|:.|
  Fly   431 PKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAI 495

  Fly   492 LVLFVLLTRLVAKIVWNKFGGKAKISQTKKK 522
             .|..|||.......:..|.|   |...||:
  Fly   496 -TLLPLLTLYAVSRNYKSFRG---IRAQKKE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	153/494 (31%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	160/515 (31%)
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	164/526 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	154/494 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454740
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.790