DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	176/542 - (32%)
Similarity:	276/542 - (50%)	Gaps:	48/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGVHFVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSML---KPKV 62
            |:.:...||||. :.||.|.|.||.:|....||..|..:...|.|...||.||.|:..   ||.|
  Fly     1 MLALRIGFLLLT-LPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVV 64

  Fly    63 THKDIHLIVVPMKEEQERIMEDQMTEMAG-----QKNSLVSTMYRLLTSMDVMINAQ-AELLSDP 121
            ..:|:.:..| ....:|.|     .|::|     |:|:.::..:..:|.. |:.|.: .|.|..|
  Fly    65 NFRDVFIPDV-FNNYKELI-----NELSGPMNLWQENNFINKFFVSVTRC-VLTNKEVTETLLPP 122

  Fly   122 RFQRIYETKFDLMILGYFINDFQLGVAHKLKVPVI------INWMSAPVPAIDKYTGNPSELSYV 180
            .     :..|||:|:....:|...|.|.....|:|      .:|      .||...||.|.|||.
  Fly   123 G-----KDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDW------NIDALVGNESPLSYT 176

  Fly   181 PLMGTVATQPMGFLKRTENALKS----LLFEFIFVVFDYKLTRIYNDVFPEQDMPT-LKELRKNI 240
            ||.....|..|.||:|..|.:.:    |.:.|:.:....|:   |...|||..... |.:|.:|.
  Fly   177 PLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKM---YAKYFPEASKRVQLTDLNRNF 238

  Fly   241 SMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSS 304
            |:..:..|.....| ||.||.:||:||:.:..||.|||||:::|| .:.:.|.::.||||||.|.
  Fly   239 SLVLLNQHFSLSFP-RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSK 302

  Fly   305 TVRPEIVQIIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKG 369
            .:..:...:|.|..:.|.:.|:||:|| :..||..||:....|.||.||||||..||||||.|..
  Fly   303 DLPADRKDLILKTFASLPQRVLWKFED-DKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLL 366

  Fly   370 GITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIG 434
            ...|:.:||.|::.||.|.||..|.....::|:||.||..::|:..|::.::.:|:..::.|...
  Fly   367 STIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIAR 431

  Fly   435 QFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIV-TILVLFVLL 498
            |.|..|||:||:...:.::||||:|||:||.:::.....:.|...::||:..::: ..|:|..::
  Fly   432 QMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAII 496

  Fly   499 TRLVAKIVWNKFGGKAKISQTK 520
            ..::.|:  ..||...|..::|
  Fly   497 VGVLGKL--TDFGNAKKKLKSK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	166/486 (34%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	161/503 (32%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	165/481 (34%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	141/434 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445683
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.840