DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	165/554 - (29%)
Similarity:	277/554 - (50%)	Gaps:	77/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHL---- 69
            ||||..:...:|..:| :|.... ||.:....|.:.|...||...|   |.|:||   :|:
  Rat    16 LLLLCALPWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVV---LAPEVT---VHMKGED 72

  Fly    70 ------IVVP-MKEEQERIMEDQMTEMAG------QKNSLVSTMYRLLTSM----DVMINAQAEL 117
                  ...| .|||.:|       |:.|      :....|.|.:..:.|:    |:..|:.|.|
  Rat    73 FFTLQTYAFPYTKEEYQR-------EILGNAKKGFEPQHFVKTFFETMASIKKFFDLYANSCAAL 130

  Fly   118 LSDPR-FQRIYETKFDLMILGYFIND--FQLG--VAHKLKVPVIINWMSAPVPAIDKYTGNPSEL 177
            |.:.. .|::..:.||::     :.|  |..|  :|..|::|.:....|.|.....:.|..|...
  Rat   131 LHNKTLIQQLNSSSFDVV-----LTDPVFPCGALLAKYLQIPAVFFLRSVPCGIDYEATQCPKPS 190

  Fly   178 SYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISM 242
            ||:|.:.|:.:..|.||:|.:|.|..|..::|          .:..:.|.:.:.: :.|::.:|:
  Rat   191 SYIPNLLTMLSDHMTFLQRVKNMLYPLTLKYI----------CHLSITPYESLAS-ELLQREMSL 244

  Fly   243 AFVGSH---------LISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSL 297
            ..|.||         .:.:.| ||::|.::.||||....| .||.::.:.:: ::.:.|.|..||
  Rat   245 VEVLSHASVWLFRGDFVFDYP-RPIMPNMVFIGGINCVIK-KPLSQEFEAYVNASGEHGIVVFSL 307

  Fly   298 GSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGN-SSNILYKNWLPQDDILAHPNTKL 361
            ||.|  |.:..:....|.:.|..:.:.|:|::..  ..|.| :.|.:...||||:|:|.||..:.
  Rat   308 GSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLLGHPKARA 368

  Fly   362 FITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLEN 426
            ||||:|..||.|...:|||||.:|:||||..||..||..|.|:.|::|.:|.|.|.:|||.|:.|
  Rat   369 FITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINN 433

  Fly   427 QKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVH-MNFIQLNNLDIYALIVT 490
            :.||:.|.:.|:|::|||:......|||.||::||:|||:|: |:.| :.:.|.::||:...::.
  Rat   434 KSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLA 497

  Fly   491 ILVLFVLLTRLVAKIVWNK-FGGKAKISQTKKKQ 523
            |::..|.:..........| ||||.::.::.|.:
  Rat   498 IVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	151/494 (31%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	157/520 (30%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	159/533 (30%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	94/252 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810