DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt49C1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	164/552 - (29%)
Similarity:	282/552 - (51%)	Gaps:	77/552 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLGVVAS----TQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVV---SMLKPKVTHKD 66
            |||.|.:.|    .:|:.||.:::....||.::|.::.:.||::||.||:|   |:.|.::....
  Fly     9 LLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNY 73

  Fly    67 IHLIVVPMKEEQERIMED-------QMTEMAGQKNSLVSTMYRLLTSMDVM-INAQAELLSDPRF 123
            ..:::.|:.:....:..:       ::|.|         |.|..|..:::: :......|..|:.
  Fly    74 TEILIEPVYDFWHDVKLNFGAQHLFELTRM---------TNYDFLKMLEIIGLKTTEHALRQPKV 129

  Fly   124 QRIY-----ETKFDLMILGYFINDFQLGVAHKLKVPVII-------NWMSAPVPAIDKYTGNPSE 176
            :.:.     |..|||::...|..:..|.:||..|:||:.       |.||..:..|..:
  Fly   130 RSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPW------ 188

  Fly   177 LSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQD------------ 229
             |:||......|..|.||:|.:|:..|         |...:.|:.| .||:.|
  Fly   189 -SFVPHGFMPFTDRMSFLERVKNSYAS---------FYEDMDRLLN-YFPKMDAVAREFFGPVLT 242

  Fly   230 -MPTLKELRKNISMAFVGSHLISEGPI---RPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQ 290
             :|.:|.:.:.||:..:.||    .|:   ||.|.|::.:||:.:. .|.|||.|:...:..|.:
  Fly   243 EVPKVKHMERQISVMLLNSH----APLTTARPTVDAMVPVGGMHIY-PPKPLPADMQALLDGATE 302

  Fly   291 GAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILA 355
            ||:|.||||||:|..:..|::::..:|...||:.|:||:|| |:......|::.:.||||.||||
  Fly   303 GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFED-ESISQLPDNVMVRKWLPQADILA 366

  Fly   356 HPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDAL 420
            |.:.|:||||.|..|..|..::.|||:.:|.:.||..|.......||.::|...||||:.||.:|
  Fly   367 HRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSL 431

  Fly   421 KEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIY 485
            .:::.|..||:.:.:.|.::||||:..::|.|:|.||::||:||.:::|..:.:|:.|...||:.
  Fly   432 DQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVI 496

  Fly   486 ALIVTILVLFVLLTRLVAKIVW--NKFGGKAK 515
            |.:..|.:..|:...|..:::.  ||...|||
  Fly   497 AFVAIIALAGVMALSLAIRLLMGSNKKHRKAK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	150/500 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	154/522 (30%)
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	152/513 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	147/492 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454741
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.840