DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	174/554 - (31%)
Similarity:	283/554 - (51%)	Gaps:	74/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLGVVASTQ-----GANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVV---SMLKPKV--T 63
            :.||.:||..|     |:.||..|.....||.::..::.:.|||.||.||.:   |:.|.|:  .
  Fly     9 IFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSN 73

  Fly    64 HKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVS----TMYRLLTSMDVM-INAQAELLSDPRF 123
            :|:   ||:|..:....|.|  ||    .||:::.    ..:..|..::|| |:.....|..|..
  Fly    74 YKE---IVIPQYDFWPEIKE--MT----NKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEI 129

  Fly   124 QRIYET-----KFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLM 183
            |.:...     |:||::...|.|:..|.:.|..::|.|..........:.:..|..|..||||..
  Fly   130 QAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHA 194

  Fly   184 GTVATQPMGFLKRTEN----ALKSLLFEFIFVVFDYKLTRIYNDVFPEQD-------------MP 231
            ....|..|...:|..|    |.:.|:.||.:              :|.||             :|
  Fly   195 YMPYTDRMTLWERIGNVAMSAAEDLVREFSY--------------YPGQDAVLKKHFSKLLDRVP 245

  Fly   232 TLKELRKNISMAFVGSHLISEGPI---RPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAV 293
            |:|||.:|||...:.|::    |:   ||:...:|.:||:.:: .|..||:.:.:|:..|..||:
  Fly   246 TIKELERNISAILLNSYM----PLASSRPMAYNMIPVGGLHIQ-PPKALPEHLQKFLDGATHGAI 305

  Fly   294 FLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPN 358
            :.||||.|:|:.:.||.:::..:|...||:.|:||:|| |:.|...:|:..::||||.|||||||
  Fly   306 YFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFED-ESLPNLPANVKVQSWLPQGDILAHPN 369

  Fly   359 TKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEV 423
            .|:||.|.|..|..||.|:|||::.:|::.||..|....:.:.|.|.||...:|.:.||..|.|:
  Fly   370 VKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMEL 434

  Fly   424 LENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALI 488
            :||.||:..|.:.|.::||||:.|..:.::|..|::.|:|||:|.:..||:.:.|...|||..|.
  Fly   435 IENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLG 499

  Fly   489 VTILVLFVLLTRLVAKIVWNKFGGKAKISQTKKK 522
            :.:::|.:::..|:.     :...|.|.:.||||
  Fly   500 LAVILLPIVVLILIC-----RRSSKPKSTPTKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	158/497 (32%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	160/516 (31%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	167/532 (31%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	159/510 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454742
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.790