DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-35

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001023694.1	Gene:	ugt-35 / 3565443	WormBaseID:	WBGene00044286	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	142/560 - (25%)
Similarity:	241/560 - (43%)	Gaps:	77/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHK------ 65
            :|.|:..:..:::..|.|......:.||......:|..|.:.|||||   .|.|.:..|
Worm     8 LFFLISILFQNSKSVNFLVYCPLFAHSHHTFLAKIADTLSEEGHNVT---FLAPIIVQKYENFKY 69

  Fly    66 ---DIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPRFQRIY 127
               ...:|.:...||.:::.|...:....:..:...:::.::.|:.         |....|.:||
Worm    70 LKHTTDIIYIQPDEELKKLGEIMGSAGFSKYWTEEPSVFSMIPSIK---------LFQKMFHKIY 125

  Fly   128 ET--------------KFDLMILGYFINDFQ-LGVAHKLKVPVIINWMSAP-VPAIDKYTGNPSE 176
            |.              |||.||  |.:..|. :.:...|.:..:....|.. ...:.|..|.|:.
Worm   126 ENLRADLSILDSLKDRKFDAMI--YEVLAFNAIAIQQYLGIKTLYPTFSVTHGMVLSKSIGEPAS 188

  Fly   177 LSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRI-YNDVFPEQDMPTLKELRKNI 240
                |...:.|..|.|.....:..|.:.:..||:.||......| |:..:.|.|   |||.....
Worm   189 ----PATLSSALSPYGEKMNFQERLMNTVCAFIYQVFMKPPKMISYSHPYYEID---LKEAESKA 246

  Fly   241 SMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQF--ISNAKQGAVFLSLGSNVKS 303
            |..|:.|:...:.| ||::...:.||||.|........:..|::  |.|.:...|.:|.||.:.|
Worm   247 SFVFLNSNPYLDFP-RPMLTKTVLIGGISVNTSQIREERLSDEYHNILNIRVKTVLISFGSIMLS 310

  Fly   304 STVRPEIVQIIFKVLSELKENV--IWKWEDLE-NTPGNSSNILYKNWLPQDDILAHPNTKLFITH 365
            :.:......||.||:.|. .||  |||:|..| :...|..|:.:..|:||..:||......||||
Worm   311 TDMPDRYKSIIVKVIEEF-PNVTFIWKYESDELDFANNLKNLHFFKWIPQTALLADSRLSAFITH 374

  Fly   366 AGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITE-DSLRDALKEVLENQKY 429
            ||.|.|.|..|.|.|.:.:|||.||..||.::.:....::|:...:.. :.||.:|.::|::..:
Worm   375 AGLGSINELSYMGKPAILVPIFADQLRNAKMLVRHNGSISLEKQDLGNFEKLRVSLAKILKDNSF 439

  Fly   430 KQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQ--GA-----PNLQSPSVHMNFIQLNNLDIY-- 485
            ::.....:....::|::.:       |.:::|.  ||     |:|...|..|:|..||.:||:
Worm   440 QENAEILARQLNNQPISPR-------ELLIKHATFGAEFGELPSLDPYSRQMSFFSLNMIDIFLF 497

  Fly   486 -ALIVTILVLFVL-LTRLVAKIVWNKFGGKA-KISQTKKK 522
             .:.:.|||.|:. ..||:..::..|   || :.||..:|
Worm   498 LGVFLAILVYFLFTFLRLLLNLLLKK---KAVEKSQENRK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	122/498 (24%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	135/525 (26%)
ugt-35	NP_001023694.1	Glycosyltransferase_GTB_type	2..464	CDD:299143	118/485 (24%)
ugt-35	NP_001023694.1	UDPGT	34..506	CDD:278624	127/501 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810