DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt301D1

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	159/533 - (29%)
Similarity:	272/533 - (51%)	Gaps:	29/533 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDI-HL 69
            ::.:.|:|::....|:.||.:....:|||.:........|::.||:||.|:....|..|::: .:
  Fly    10 WMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEI 74

  Fly    70 IVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPRFQRIYETK---F 131
            |:.|..:..:...::.:..|     ..||....|.....:.:........||:.:::.|:|   :
  Fly    75 IISPSFDIPKHFPKENIFSM-----QFVSDFNNLELWWTIGLMTTEHAFKDPKVKKLIESKDDHY 134

  Fly   132 DLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGTVATQPMGFLKR 196
            ||:|:..|.::..|....:...||:..........||...|..:..|.:|.:....|..|.|.:|
  Fly   135 DLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQR 199

  Fly   197 TENALKSL----LFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISMAFVGSHLISEGPIRP 257
            ..||..||    :..::::....||...|.....|..:|.:.:|.:|||:..:.:|...:.| ||
  Fly   200 AYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLP-RP 263

  Fly   258 LVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELK 322
            .:|.||::||..:: ||..||.|:..|:.||..|.::.|:||.|||:.:..|...:|.|...:||
  Fly   264 SMPGLIDVGGAHIQ-KPKQLPTDLQNFLDNATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLK 327

  Fly   323 ENVIWKWED--LENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALP 385
            :.||||:|:  :.:.|   ||::.|.|:||:|||||||.||||||.|..|..|..|.||||:.:|
  Fly   328 QQVIWKFENDSIGDLP---SNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVP 389

  Fly   386 IFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQS 450
            ::|||..|.....:.||..:|....:|.|.|...::.::.:.:||::..:.|..:||.|:.....
  Fly   390 LYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDE 454

  Fly   451 VVFWTEYILRHQGAPNLQSPSVHMNFIQLNN---LDIYALIVTILVLFVLLT-RLVAKI--VWNK 509
            ..||.|||:||:||.:|:|   |..||.|:.   ||:...::....|.:.|. |::.::  .|.|
  Fly   455 ATFWIEYIIRHRGARHLKS---HGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWRMIRRVHKWWLK 516

  Fly   510 FGGKAKISQTKKK 522
            .....|:::.||:
  Fly   517 GESSNKLNEGKKR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	143/470 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	150/497 (30%)
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	149/483 (31%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	143/458 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.910