DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	154/508 - (30%)
Similarity:	256/508 - (50%)	Gaps:	67/508 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHLIIHMSVAKALVKAGHNVTVV---------SMLKP------------KVTHKDIHLI------ 70
            ||.:...::.:.|...||.|||:         |.|.|            :|....::.|
  Rat    34 SHWLNLKTILEELAARGHEVTVLKYPSIIIDQSKLTPLQFENIPVLYETEVAENHLNEIVNLAVN 98

  Fly    71 VVPMKE--EQERIMEDQMTEMAGQKNSLV-STMYRLLTSMDVMINAQAELLSDPRFQRIYETKFD 132
            |:|...  |..|.::|...::.|....|. ||:|.     ..::|            ::.:.|:|
  Rat    99 VIPNLSLWEAARTLQDFFLQLTGNFEDLCRSTLYN-----QTLMN------------KLRDAKYD 146

  Fly   133 LMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGN-PSELSYVPLMGTVATQPMGFLKR 196
            :|:|...|...:| ||..|::|.:.....:...:::||.|. |..|||||::....|..|.|.:|
  Rat   147 VMVLDPVIPCGEL-VAEVLQIPFVNTLRFSMGYSMEKYCGQLPVPLSYVPVVMGELTDHMTFTER 210

  Fly   197 TENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISMA---FVGSHLISEGPIRPL 258
            .:|.:.||.|||....:|:    .:.|.|..:.:.......|.:..|   .:.::...|.| ||.
  Rat   211 VKNMMLSLFFEFWLQQYDF----AFWDQFYSKTLGRPTTFCKTVGKAEIWLIRTYWDIEFP-RPY 270

  Fly   259 VPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELK 322
            :|....:||:..| ...||||::::|: |:.:.|.|..||||.:|:.|  .|...:|...|:::.
  Rat   271 LPNFEFVGGLHCK-PAKPLPKELEEFVQSSGEHGVVVFSLGSMIKNLT--EEKANLIASALAQIP 332

  Fly   323 ENVIWKWEDLE-NTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPI 386
            :.|:|::...: .|.|.::.||  ||:||:|:|.||.|:.||||.|..||.||.|||||||.:|:
  Rat   333 QKVLWRYSGKKPATLGPNTRIL--NWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPM 395

  Fly   387 FGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSV 451
            |||||.|.|.||..|..:.:.:.::|...|..||:.|:....||:...:.|.::.|:|:......
  Rat   396 FGDQPYNIAHMEAKGAAVKVAINTMTSADLLSALRAVINEPSYKENAMRLSRVHHDQPVKPLDRA 460

  Fly   452 VFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAK 504
            |||.|:::||:||.:|:..:..:::.|.::||:   |..:||..|.||.::.|
  Rat   461 VFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDV---IGFLLVCVVTLTFVITK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	143/469 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	154/508 (30%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	154/508 (30%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	92/245 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740