DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	141/529 - (26%)
Similarity:	249/529 - (47%)	Gaps:	87/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHLIIHMSVAKALVKAGHNVTVVS-----MLKPKVTHKDIHLI-----VVPMKEEQERIMED--- 84
            ||.:....:...||:.||.|||:.     .|.||   |...|:     .....:|.|:....
  Rat    34 SHWMNLKIILDELVQRGHEVTVLRPSSSVFLDPK---KASGLVYETFPTTSNNDEVEKFFTQWVN 95

  Fly    85 ----------------QMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPRFQ-RIYETKFD 132
                            .:.:|.||.:             |:.:....|::|:.... ::.|::||
  Rat    96 TWTYDVPKYTCLRYYPSLNKMFGQFS-------------DLWLQLCREVVSNKHLMAKLKESQFD 147

  Fly   133 LMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYT-GNPSELSYVPLMGTVATQPMGFLKR 196
             ::|...:......:|..|::|.:.:........|:||: |.|...||||::.:..:..|.|::|
  Rat   148 -VVLSDAVGPCGELIAEILQLPFVYSLRFGIGYGIEKYSAGQPFPPSYVPIILSGLSGQMTFMER 211

  Fly   197 TENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDM-----------PTLKELRKNISMAFVGSHLI 250
            .||.|..|.|:|.|            :.||.:|.           .|:.:..|...:..:.|:..
  Rat   212 VENMLCLLYFDFWF------------ESFPAKDWDPFFSEILGRPTTMVDTMKKAEIWLIRSYWD 264

  Fly   251 SEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRPEIVQII 314
            .|.| ||.:|.:..:||:..: ...||||:::.|. |:.:.|.|..||||.:::.|  .|....|
  Rat   265 LEFP-RPSLPNIEFVGGLHCQ-PAKPLPKEMEDFAQSSGEHGVVVFSLGSMIRNIT--QERANTI 325

  Fly   315 FKVLSELKENVIWKWEDLE-NTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHG 378
            ...|:::.:.|.|::|..: :|.|.::.:.  .|:||:|:|.||.||.|:||.|..||.|:.:||
  Rat   326 ASALAQIPQKVFWRFEGKKPDTLGPNTRVF--KWIPQNDLLGHPKTKAFVTHGGANGIYESIHHG 388

  Fly   379 VPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDR 443
            :|||.:|:|.:|..|.|.|...|..::||..:::...|.:|||.|:....||:.:...|.::.|:
  Rat   389 IPMVGIPLFAEQRDNVAHMVAKGAAVSLDFHTMSSSDLLNALKAVINKPSYKKKVMWLSAIHHDQ 453

  Fly   444 PMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLT--------R 500
            |:......|||.|:::||:||.:|:..:.::.:.|.::||:...::..::..|||.        |
  Rat   454 PLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLAWYQYHSLDVIGFLLACVLAIVLLAVKCCLFLYR 518

  Fly   501 LVAKIVWNK 509
            ...|:..||
  Rat   519 FFVKVAKNK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	130/477 (27%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	141/529 (27%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	139/527 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810