DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	166/541 - (30%)
Similarity:	275/541 - (50%)	Gaps:	58/541 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLGVVASTQGANILG--LFSSHSPSHLIIHMSVAKALVKAGHNVTVVS-----MLKPKVTHKD 66
            ||||.:....|..| .|  |......||.:...::...||:.||.|||:.     :|.||.: .|
  Rat     9 LLLLQISCCFQSGN-CGKVLVWPMEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKS-PD 71

  Fly    67 IHLIVVP---MKEEQE----RIMEDQMTEMAGQKNSLVS------------TMYRLLTSMDVMIN 112
            :.....|   .|:|.|    ::::....|:  |:::.:|            :.|.|....|.:.|
  Rat    72 LKFETFPTSVSKDELENYFIKLVDVWTYEL--QRDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSN 134

  Fly   113 AQAELLSDPRFQRIYETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGN---P 174
            .|.       ..::.|:|||:::........:| :|..|.:|.:.:...:|...|:|.:|.   |
  Rat   135 KQL-------MAKLQESKFDVLLSDPVAACGEL-IAEVLHIPFLYSLRFSPGYKIEKSSGRFILP 191

  Fly   175 SELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFD-YKLTRIYNDVFPEQDMPTLKELRK 238
            .  ||||::.:....||.|:.|.:|.:.:|.|:|.|.:|: .|....|:::....  .||.|...
  Rat   192 P--SYVPVILSGMGGPMTFIDRVKNMICTLYFDFWFHMFNAKKWDPFYSEILGRP--TTLAETMG 252

  Fly   239 NISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVK 302
            ...|..:.|:...|.| .|.:|.:..|||:|.: .|.|||||::.|: |:.:.|.|..||||.|.
  Rat   253 KAEMWLIRSYWDLEFP-HPTLPNVDYIGGLQCR-PPKPLPKDMEDFVQSSGEHGVVVFSLGSMVS 315

  Fly   303 SSTVRPEIVQIIFKVLSELKENVIWKWEDLENTP---GNSSNILYKNWLPQDDILAHPNTKLFIT 364
            |.|  .|....|...|:::.:.|:||::.  .||   |.::.: || ||||:|:|.||.||.|:|
  Rat   316 SMT--EEKANAIAWALAQIPQKVLWKFDG--KTPATLGPNTRV-YK-WLPQNDLLGHPKTKAFVT 374

  Fly   365 HAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKY 429
            |.|..|:.||.|||:|||.:|:||:|..|.|.|...|..:.|::.::::..|.:||||::.|..|
  Rat   375 HGGANGVYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFY 439

  Fly   430 KQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVL 494
            |:.....||::.|:||......|||.|:::||:||.:|:....::.:.|.::||:...::|...:
  Rat   440 KKNAVWLSTIHHDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAV 504

  Fly   495 FVLLTRLVAKIVWNKFGGKAK 515
            ..:||......::..|..|.|
  Rat   505 IAVLTVKSFLFIYRLFVKKEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	156/491 (32%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	157/513 (31%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	160/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740