DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt50B3

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	150/558 - (26%)
Similarity:	265/558 - (47%)	Gaps:	82/558 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHLIV 71
            :||::..  ..|..|:||......:.||.|....:||.|:..|||:|.:|..
  Fly     7 LFLIIWS--CGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGF------------- 56

  Fly    72 VPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQA-------------------EL 117
             |.....|.::|   ...||    ||..::. .|:.|::.:..|                   .:
  Fly    57 -PADFNIEGLLE---VTPAG----LVEYIHN-YTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAM 112

  Fly   118 LSDPRFQRIYETKFDLMIL-GYFINDFQLGVAHKLKVP-VIINWMSAPVPAIDKYTGNPSELSYV 180
            |.|...:.:.:..|||.|| |.|...| ||:.:..|:| :.||.:.....:|.. .|||...:..
  Fly   113 LRDSETKELTKKSFDLAILDGAFPECF-LGLMYDFKIPFMYINTVGFYTGSIST-AGNPVSYAIT 175

  Fly   181 PLMGTVATQPMGFLKRTENAL----KSLLFEFI-----FVVFDYKLTRIYNDVFPEQDMPTLKEL 236
            |...:..|..|...:|..|..    ::|:..::     .|:.::..|:|          |...|:
  Fly   176 PNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQI----------PHPYEM 230

  Fly   237 RKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSN 300
            .:|:|......|.:...| |...|.:.|:..|..: ....||:::::|| ::...|.:::|:||:
  Fly   231 SRNVSFILQNGHAVLSYP-RAFNPNVAEVACIHCR-PARKLPRNLEEFIGASGASGFIYVSMGSS 293

  Fly   301 VKSSTVRPEIVQIIFKVLSELKENVIWKWE----DLENTPGNSSNILYKNWLPQDDILAHPNTKL 361
            ||::.:...:..::.|..:.|..:|:||:|    |:::.   :||:....||||.|||.||..:.
  Fly   294 VKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDI---TSNVKLSRWLPQQDILGHPKLRA 355

  Fly   362 FITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLEN 426
            |:||.|...:.|..|||||:|.:|:|.|...|:|..|..||.:.|||.:::.:.|..|:.:|:.|
  Fly   356 FVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHN 420

  Fly   427 QKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTI 491
            .:|:.:......|:.|:..||..:.::||||:|||.||.:||:||.:|.:.|...||:.|:.:.:
  Fly   421 PRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLIL 485

  Fly   492 LVLFVLLTRLV------AKIVWNKFGGKAKISQTKKKQ 523
            |.:.:|..|.:      .:.:::.......|::||.|:
  Fly   486 LYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	134/494 (27%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	140/522 (27%)
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	115/444 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	95/321 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.820