DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt-10

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_504313.2	Gene:	ugt-10 / 188619	WormBaseID:	WBGene00020594	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	152/568 - (26%)
Similarity:	247/568 - (43%)	Gaps:	93/568 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTV-------VSMLKPKVTHK 65
            |||:|.|.....|.|||........||:.....:|..:...||||||       :...:..:.:|
Worm     7 FLLILCVFPIILGKNILIFNPIFGFSHVKFVSKLADIIADHGHNVTVFQPFHIALKNTEGLIKNK 71

  Fly    66 DIHLI-VVP------MKEEQE--------RIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQA 115
            :|..| ..|      :|.|.:        .:|.:.:........:|.||..|..|
Worm    72 NIKFINYYPDHYDELLKTETQTFPMFWDSHLMNNPVVSAVMMAKALSSTFERTAT---------- 126

  Fly   116 ELLSDPR-FQRIYETKFDLMILGYFINDFQLG---VAHKLKVPVIINWMSAPVPAIDKYTGNPSE 176
            :|:.|.. ...:...|||:||    ...|:|.   |||.:.||.|..|.:......:|..|.||.
Worm   127 QLVKDQNVLNNLKSKKFDVMI----SETFELTGMYVAHLINVPCIPIWSAVRFLVFNKAFGQPST 187

  Fly   177 LSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNIS 241
            |.|:||.|:......||                   || :|..:|.|.|.:..|..|.:.:.||.
Worm   188 LGYIPLEGSKMAPDFGF-------------------FD-RLNDVYRDFFGQIGMDRLGQYQNNII 232

  Fly   242 MAFVG------SHLISEGPI-----RPLV-------PALIEIGGIQV---KDK-PDPLPKDIDQF 284
            ...||      ..|:|:.||     .|.:       ||::.||||.:   |.| .|.||::.::.
Worm   233 EKAVGHSVPYWKDLVSQSPIYITNSNPYLDFAVATTPAIVHIGGITIDLEKIKHADELPEEYEKI 297

  Fly   285 ISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKE-NVIWKWE--DLENTPGNSSNILYKN 346
            :.. ::..|.:|.||.::|..:.......:.|:...|.: ..|||:|  |:|.......|:..|.
Worm   298 LQE-RESTVLISFGSVIRSYEMPDNFKAGLIKMFESLPDVTFIWKYERDDVEFQKRLPKNVHLKK 361

  Fly   347 WLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSI 411
            |:||..:||....|||:||.|.|...|..|.|.|.:::|||||||.||.::.:.|..:|.|...:
Worm   362 WVPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALSVPIFGDQPENADMLARHGGAIAYDKFDL 426

  Fly   412 TE-DSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQS--PSVH 473
            .. :.|...::|::.|.|:.:.......:...:|:..|.:::...|:.:..   ||.:|  |:::
Worm   427 ANGEKLTKTVREMVTNPKFSKNAEALRDVLLKQPIDPKMNLMKHLEFAMEF---PNHRSQVPAIN 488

  Fly   474 -MNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVWNKFGGKAKISQTK 520
             :.:|....||:.|.:..::|.|:.|.....|||:.:.|...|.::|:
Worm   489 KLGWIAHYYLDVIAFLTLVVVGFLYLIFRFTKIVFVRIGILNKKAKTE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	136/510 (27%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	141/536 (26%)
ugt-10	NP_504313.2	egt	1..463	CDD:223071	133/490 (27%)
ugt-10	NP_504313.2	UDPGT	31..535	CDD:278624	142/541 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810