DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-8

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_504315.1	Gene:	ugt-8 / 186768	WormBaseID:	WBGene00019234	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	135/545 - (24%)
Similarity:	234/545 - (42%)	Gaps:	66/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTV-------VSMLKPKVTHKD 66
            |.:|.|:.|....|||........||:.....:|..:...|||||:       :...:..:.:|.
Worm     7 LSILLVLGSVSCKNILIFNPIFGLSHVKFISKMANIIADHGHNVTLFQPFHIALKNTEGLIKNKY 71

  Fly    67 IHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAE-----LLSDP-RFQR 125
            |.:|........|.:..:..|..|...:.|::........:...|..:.|     ||.|. ....
Worm    72 IEIINYYPDHYDELLKTETATFPAFWDSHLMNNPVLSAFMIPKAIAGEFERTATQLLKDKVALDD 136

  Fly   126 IYETKFDLMILGYFINDFQLG---VAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGTVA 187
            :....||::|    ...|:|.   :||.|.||.|..|.:......:...|.||.|.|       :
Worm   137 LKSRNFDVII----SETFELTGMYIAHMLNVPCIPVWSAVRFTIFNNIFGQPSSLGY-------S 190

  Fly   188 TQPM-------GFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPE---QDMPTLKELRKNISM 242
            .||.       ||:.|..:..::    |.|.:....:.:..||...:   :.:|..|:|.|...:
Worm   191 QQPFSKLAPEAGFIDRLNDVYRN----FFFTITMDGMGQYQNDFIEKAVGRPLPYWKDLIKEAPV 251

  Fly   243 AFVGSHLISEGPIRPLVPALIEIGG----IQVKDKPDPLPKDIDQF--ISNAKQGAVFLSLGSNV 301
            .|..|:...:..: |....::.|||    ::.....||||   |::  |...::..|.:|.||.:
Worm   252 YFTNSNEYLDFAV-PTTATIVHIGGFTMDLEKMKHVDPLP---DKYAKILEERESTVLISFGSVI 312

  Fly   302 KSSTVRPEIVQIIFKVLSELKE-NVIWKWE--DLENTPGNSSNILYKNWLPQDDILAHPNTKLFI 363
            :|..:.......|.|:...|.: ..|||:|  |:|.......|:..|.|:||..:||....|||:
Worm   313 RSYQMPDNFKAGIIKMFESLPDVTFIWKYERDDVEFQKKLPKNVHLKKWVPQHSLLADNRVKLFV 377

  Fly   364 THAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITE-DSLRDALKEVLENQ 427
            ||.|.|...|..|.|.|.:.:|||||||.||.::.:.|..::.|...:.: :.|...:::::.|.
Worm   378 THGGLGSTMEVAYTGKPALMVPIFGDQPENANMLARHGGAISYDKFELADGEKLAITIRDMVRNP 442

  Fly   428 KYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQS--PSVH-MNFIQLNNLDI----- 484
            ||.:...:...:...:|:..|.:::...|:.:..   |||:|  |::: |..|....||:
Worm   443 KYNKNAQELLKVLSHQPIDPKLNLMKHLEFAMEF---PNLRSQVPAINQMGLIAHYYLDVIFFLS 504

  Fly   485 YALIVTILVLFVLLTRLVAKIVWNK 509
            ...|:|:.:.|.:::.|..:||.:|
Worm   505 LIFILTVYLTFKIISLLPIRIVKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	120/493 (24%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	128/521 (25%)
ugt-8	NP_504315.1	UDPGT	30..516	CDD:278624	123/507 (24%)
ugt-8	NP_504315.1	egt	<284..462	CDD:223071	54/180 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810