DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-65

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_502373.3	Gene:	ugt-65 / 184205	WormBaseID:	WBGene00008583	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	131/540 - (24%)
Similarity:	228/540 - (42%)	Gaps:	92/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTV--VSMLKPKVTHKDIHL 69
            :..||...:.::..:.||.|...:|.||.:..|.:|:.|...||:|::  :|..:.|:..|.:.:
Worm    10 IIFLLAHFLTTSNCSRILFLNMFNSKSHALTMMPLAERLFDDGHDVSMYTISANRLKIPSKKVKI 74

  Fly    70 IVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQA----------ELLSDPRFQ 124
            :        |.:::...|:.|......||   |:..|.::.....|          |...|.:..
Worm    75 L--------ESLVKGSSTDDAAPDTGGVS---RIFWSYEMTPYVGAWCYEIGLYYLEEGRDEQLD 128

  Fly   125 RIYETKFDLMILGYFINDFQLGVAHKLK---------------VPVIINWMSAPVPAIDKYTGNP 174
            .:..|.:||.::.......|..:|.|||               :||..|...        |..||
Worm   129 EVLATPYDLAVVDETYTSLQGSIALKLKEDHSTKIITFATTELMPVASNMRG--------YARNP 185

  Fly   175 SELSYVPLMGTVATQPMGFLKRTENALKSLLFE---FIFV-----VFDYKLTRIYN----DVFPE 227
                        .|.|..||      |.|.::|   |.|:     :|:|.:.:||:    .::.|
Worm   186 ------------VTVPNTFL------LSSEVYEGNRFAFLTRTRRIFEYFIDQIYSGPVASLYSE 232

  Fly   228 QDMPTLKELRKNISMAFVGSHL-ISEGP-----IRPLVPALIEIGGIQVKDKPDPLPKDIDQFIS 286
            .....|.......|..|..|.| :::.|     ::|....||.:|  :.......||.:...|:.
Worm   233 ASGKLLGLTSATKSKTFQNSILTVNDFPDTFSFVQPRGNDLIRVG--EHCYSSANLPSEFRDFVE 295

  Fly   287 NA-KQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKE-NVIWKWEDLENTPGNSSNILYKNWLP 349
            :: .:|.:::::||.:.........|:...:.|:..|: .|||..:.  |..|...::...||.|
Worm   296 DSMSKGTIYVAMGSYLNLEDGPKGTVEAFIEALNYFKDYRVIWSHKG--NVTGAKCHVKSVNWAP 358

  Fly   350 QDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITED 414
            |.::|||..|..||||.|.....|....||||:.||.:||||.||.....:|...||...:||..
Worm   359 QKELLAHEKTVAFITHGGLKSAKEGVCSGVPMLFLPFYGDQPRNAHRFVTNGIAEALYKKAITSL 423

  Fly   415 SLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGA--PNLQSPSVHMNFI 477
            .::..|:::|.:..||..:.:..:.|.|.|:::.....|....:||...:  ...:..|:.||.:
Worm   424 DIQQKLEKLLVDPSYKNNVMKVLSYYLDAPISSLDLGAFHISQVLRRTESQYSKFKRRSIFMNHL 488

  Fly   478 QLNNLDIYALIVTILVLFVL 497
            |..||||:  :|.:::||::
Worm   489 QYLNLDIF--LVILVILFIV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	120/508 (24%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	125/514 (24%)
ugt-65	NP_502373.3	egt	<300..505	CDD:223071	62/208 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010