DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt-21

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001293944.1	Gene:	ugt-21 / 183141	WormBaseID:	WBGene00007885	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	130/552 - (23%)
Similarity:	248/552 - (44%)	Gaps:	67/552 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVV-----SMLKPKVTHKDI-H 68
            :|..:::......||...:....||:.:..:.|..|..||:||||:     :.|:.|.:.|.. :
Worm     9 ILTSIISCVSSYKILLYSNLFGHSHVKVLAAAADILTDAGNNVTVLMPVFDNNLRNKTSLKSTKN 73

  Fly    69 LIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAE----LLSDP-RFQRIYE 128
            .|.|......|.:|.|....:|............::.:...|..|.||    ::|:| ..:::..
Worm    74 TIFVEAGPNVEELMSDMRQFLANAWKEDTGNPITMMKAAQDMGTAFAEQCTKVISEPGLLEKLKA 138

  Fly   129 TKFDLMILGYFIN-DFQLGVAHKLKVPVIINWMSAPVPAIDKYT---GNPSELSYVPLMGTVATQ 189
            ..:||.|...|.. .:.|..|..::..|.|    ......|..|   |.|...||||...:....
Worm   139 ENYDLAITEPFDTCGYALFEAINIRAHVAI----LTANRFDHVTDVIGQPIASSYVPGTQSETGD 199

  Fly   190 PMGFLKRTENALKSLLFEFIFVVF---DYK-------LTRIYNDVFPEQDMPTLKELRKNISMAF 244
            .|...:|..|..:.|:..:.|.:.   |::       :||.:..:.||              .:|
Worm   200 RMTMGERLGNYFQFLVGSYFFSLIGDRDFEAAKSVVPITRSWRAILPE--------------ASF 250

  Fly   245 VGSHLISEGPI----RPLVPALIEIGGIQVKDKPDPLPKDIDQF--ISNAKQGAVFLSLGSNVKS 303
            :   |.::.|:    .|....::.|||:.||.:...|..| :::  |...::..||:|.|||.||
Worm   251 I---LTNQIPLLDFPAPTFDKIVPIGGLSVKTEKKNLKLD-EKWSKILGIRKNNVFISFGSNAKS 311

  Fly   304 STVRPEIVQIIFKVLSELKENV-IWKWEDLENTPGNS-SNILYKNWLPQDDILAHPNTKLFITHA 366
            ..:..|....:..|...:.:.. |||:|:..:...|. .|:...:||||:::||.|...:|:||.
Worm   312 VDMPDEFKNSLADVFKSMPDTTFIWKYENTSDPIVNHLDNVHLGDWLPQNELLADPRLSVFVTHG 376

  Fly   367 GKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDS-LRDALKEVLENQKYK 430
            |.|.:||....|.|.|.:|:|.||..||.::::.|..:.::..::.:.. :::.|::|:::.||.
Worm   377 GLGSVTELAMMGTPAVMIPLFADQGRNAQMLKRHGGAVVIEKNNLADTHFMKETLEKVIKDPKYL 441

  Fly   431 QAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTI---- 491
            :...:.:.:..::|...|::::.:.|:..|....|:|.:...|.::|:...|||.|::..|
Worm   442 ENSKRLAEMLTNQPTNPKETLIKYVEFAARFGKLPSLDNYGRHQSYIEYFFLDIIAILAVISLFS 506

  Fly   492 -LVLFVLLTRLVAKIVWNKFGGKAKISQTKKK 522
             .:.:::|..::.||.:      :|.|:.|.|
Worm   507 LYISYIILRAVIRKIFF------SKCSEVKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	115/490 (23%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	123/520 (24%)
ugt-21	NP_001293944.1	UDPGT	32..526	CDD:278624	123/521 (24%)
ugt-21	NP_001293944.1	egt	<263..504	CDD:223071	66/241 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810