DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-23

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001076755.1	Gene:	ugt-23 / 181205	WormBaseID:	WBGene00007650	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	147/548 - (26%)
Similarity:	240/548 - (43%)	Gaps:	89/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LFSSHSP------------SHLIIHMSVAKALVKAGHNVTVV-----SMLKPKVTHKD-IHLIVV 72
            ||:..||            ||:....||...||.|||:||||     |..|.:.:.|. ...|::
Worm    12 LFNVSSPYKILVYSNLFGHSHIKFVGSVVDTLVDAGHDVTVVLPVIDSTQKNRTSIKSGAKQIII 76

  Fly    73 PMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLS-------------DPRFQ 124
            ...||        :.|:..|....:|.|:.:..|..:|:.....:|:             .....
Worm    77 DADEE--------VVEIFSQTEKFLSNMWTMEMSNPLMMWMNPRILTQLFGKQCTKVMKLSELLD 133

  Fly   125 RIYETKFDLMILGYFINDFQLGVAHKLKVPVIINWMS-APVPAIDKYTGNPSELSYVPLMGTVAT 188
            ::...||||.|...| :....|:...|::|..::.:| |.:..:....|.|...||||...::.:
Worm   134 QLKSEKFDLAITEAF-DSCGYGIFEYLQIPAHVSILSCARMDHVSDVLGQPIAPSYVPGTQSLYS 197

  Fly   189 QPMGFLKRTENALKSLLFEFIFV-VFDYK---------LTRIYNDVFPEQDMPTLKELRKNISMA 243
            ..|...:|..|.|:.|....:|. :.||:         :.|.:.::.||             |..
Worm   198 DRMTMTQRFLNYLQFLNGNSMFSDIGDYESANAKKLLGVERSWREILPE-------------SSF 249

  Fly   244 FVGSHL-ISEGPIRPLVPALIEIGGIQVKDKPDPLPKD--IDQFISNAKQGAVFLSLGSNVKSST 305
            .:.:|: :.|.| .|....::.||||.|....:.|..:  .|..:|..|:. |.:|.|||:||..
Worm   250 LLTNHIPVLEFP-APTFDKIVPIGGISVNKNKETLKLEHYFDTMVSMRKKN-VIISFGSNIKSMD 312

  Fly   306 VRPEIVQIIFKVLSELKE-----NVIWKWEDLEN---TPGNSSNILYKNWLPQDDILAHPNTKLF 362
            :..|..    |.|:||.:     ..|||:|:|.:   |.| ..||....|:||.::||......|
Worm   313 MPDEYK----KSLAELFQLMPDVTFIWKYENLADKKYTCG-IMNINRVEWIPQTELLADSRVDAF 372

  Fly   363 ITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITE----DSLRDALKEV 423
            |||.|.|.:||....|.|.|.:|||.||..||.::::.|   ..::|..|:    ::||..|::|
Worm   373 ITHGGLGSVTELATMGKPAVVIPIFADQTRNAEMLKRHG---GAEVLHKTDLANPETLRKTLRKV 434

  Fly   424 LENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALI 488
            :::..|:|...:.:.:..::|...|:::|...|:..|....|::.....|.|.|:..||||.|:.
Worm   435 MDDPSYRQNAQRLAEMLNNQPTNPKETLVKHVEFAARFGKLPSMDPYGRHQNIIEYYNLDILAIA 499

  Fly   489 VTILVLFVLLTRLVAKIVWNKFGGKAKI 516
            ..:|.|.|.|......:|.....||.|:
Worm   500 TILLTLVVYLKIFAVGVVVRCCCGKKKV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	131/497 (26%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	142/526 (27%)
ugt-23	NP_001076755.1	UDPGT	20..526	CDD:278624	142/537 (26%)
ugt-23	NP_001076755.1	Glycosyltransferase_GTB_type	40..474	CDD:299143	122/465 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810