DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-57

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_509182.1	Gene:	ugt-57 / 180969	WormBaseID:	WBGene00017154	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	598	Identity:	138/598 - (23%)
Similarity:	245/598 - (40%)	Gaps:	127/598 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSML----KPKVTHKDI 67
            :.:||||:.......|||......:.....|...:|:.|....|||..:..:    :|::....:
Worm     3 ILILLLGLTQIVTSLNILVFLLGTNQFERNIFEFLAQQLALRHHNVISIKPVLIPEEPRLVKPKL 67

  Fly    68 HLIVVPMKEEQERIMEDQMTE--MAGQKNSLVSTMYRLLTSMDVMI-------NAQA-ELLSDPR 122
            ||:       :|:::::.:.:  ....::::.:..:|.....|..:       ||.. :||:...
Worm    68 HLV-------REKVIKNVLNKDLFKPLEDAVPNAAWRSTYDFDNYLEPYYKAHNASCYKLLNSNL 125

  Fly   123 FQRIYETKFDLMILGYFINDFQLGVAHKLKVPVI------------------INWMSAP------ 163
            ...:.:...||.|: |..|.....:.|.:.||.|                  |:.::.|
Worm   126 VDSLKKESLDLAIV-YSGNPCLNALTHLVAVPTIYFDTEGLTDETLIAAGAPIDLLTPPSHCFIA 189

  Fly   164 ----VPAIDKY-------------TGNPSELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFV 211
                .|.::.|             .|.|:..|.|.....:..:|:..:.||:..:|.....|
Worm   190 ESKGYPILNLYKNSVCYFQEMIAQLGLPAVSSLVSSRHRLLDEPITNIFRTDYTIKKRFKNF--- 251

  Fly   212 VFDYKLTRIYNDVFPEQDMPTLKELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDP 276
                               |.:..|::..:..||.:..:.|.| |.|...:|.:||:.: |.|.|
Worm   252 -------------------PNVNTLKQQSAAYFVNTDPLLEPP-RALPLNVIPVGGLHI-DHPKP 295

  Fly   277 LPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWE----------D 331
            |....:..|::||:|.:.:|.|:...||.:.....:.|.|.|:.|.:..|: |.          |
Worm   296 LFSPWNTTIASAKEGLIIVSFGTQADSSKMSEYHAKAILKALTNLNDYRIY-WRIGPNMHLDGID 359

  Fly   332 LENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAAL 396
            :|..|   .:|....::||:|:|||.:.|||:|:.|...:.||..||||:|.:|::|....|...
Worm   360 IEKIP---KHINLTTFIPQNDLLAHKSCKLFVTNGGMSSVMEAVAHGVPIVGVPLYGSNRYNLQK 421

  Fly   397 MEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRDR---PMTAKQSVVFWTEYI 458
            :...|.|:.:|...:.|.||..|:|:|||:.|||....:.|..::.|   |..|...|:   ::|
Worm   422 VSNKGLGIVIDKDDLNEISLYGAMKKVLESAKYKNTAKEMSKEFKSRTTSPFAAALHVI---DHI 483

  Fly   459 LRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILV----LFVLLTRLVAKIVWN----------- 508
            .||.....:| |:....:   ..:|.|.|::.||:    |.:..|..:.....|
Worm   484 GRHHSFAYMQ-PAFQPIY---TRVDFYLLLLIILLPVIPLHLFFTFCIKSSAMNVQDNKVLEAER 544

  Fly   509 KFGGKAKISQTKK 521
            ||..| |:.:|||
Worm   545 KFLPK-KVPETKK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	121/527 (23%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	127/564 (23%)
ugt-57	NP_509182.1	GT1_Gtf-like	<168..477	CDD:340817	85/336 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910