DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt-46

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_508112.1	Gene:	ugt-46 / 180404	WormBaseID:	WBGene00015141	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	138/548 - (25%)
Similarity:	246/548 - (44%)	Gaps:	50/548 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VHFVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIH 68
            :..:|:||...|.:.....||....:.|.||||.:..:|..|.:|||:|||:     ::....|.
Worm     1 MRLIFVLLATFVNAAFSYKILVFSPATSKSHLISNGRLADELARAGHDVTVL-----ELDFLGIS 60

  Fly    69 LIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTS-------------MDVMINAQAELLS- 119
            .....:|..::||: |...|....||.|......::..             .:|..:..||.|.
Worm    61 QTTNSVKVAKKRII-DGFQESTNFKNVLHGFSETVMEEPSFTDEIKGWWAYQNVYNDLCAEFLKM 124

  Fly   120 DPRFQRIYETKFDLMILGYFINDFQL---GVAHKLKVP--VIINWMSAPVPAIDKYTGNPSELSY 179
            |..|..:...|||    |:|.....|   |.||.|::|  .:|:......|..| :||.|...|.
Worm   125 DDIFNELKNAKFD----GFFAEQINLCGFGYAHALEIPRHFLISSCPFAAPVYD-FTGLPMPTST 184

  Fly   180 VPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISMAF 244
            |.....::..|. :.:|..|...::|.:..|.:.:.:|...:...|.|. .|:|..:..::.:.|
Worm   185 VAFAADLSISPT-YTERARNLFVAVLTKLEFTLLNNRLQAHFQHKFGEH-FPSLYSVTSDVDVIF 247

  Fly   245 VGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPE 309
            |.:..|.:.....| ..::.:||:.|.|....:.......:|..|:|.::.|||:...::.:..:
Worm   248 VATDEIIDISTTTL-QNIVHVGGLGVDDDVAEMDNVFASEMSKGKEGVIYFSLGTIANTTKIDSK 311

  Fly   310 IVQIIFKVLSELKE-NVIWKWE--DLENT--PGNSSNILYKNWLPQDDILAHPNTKLFITHAGKG 369
            :::.:..::.:..: :.:.:.:  ||...  ..:.||....:||||..||.||..||||||:|..
Worm   312 VMRTVLDIVKKFPDYHFVIRADKYDLSTREYAKSVSNAFVSDWLPQPAILHHPRLKLFITHSGYN 376

  Fly   370 GITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGL---ALDLLSITEDSLRDALKEVLENQKYKQ 431
            .|.||...|||::.:|...||..|:..:||.|:|:   ...||:..|: :..|:.|::.|:||..
Worm   377 SIVEAARAGVPLINIPFMFDQNLNSRAVEKKGWGIRRHKKQLLTEPEE-IEKAISEIIHNKKYSL 440

  Fly   432 AIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFV 496
            ...:...|.:.:|:::.|.::..||:.:::.|...::..|.........|||:      |:.:|.
Worm   441 KAQRIRDLIKSKPLSSSQLLIKTTEWAIKNHGLDEIKFESRGQTTWTYYNLDV------IIPVFW 499

  Fly   497 LLTRLVAKIV--WNKFGGKAKISQTKKK 522
            |...||...:  |.||.....:.:.|.|
Worm   500 LSISLVIPTIFGWYKFSCFGHVEEKKGK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	124/489 (25%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	129/510 (25%)
ugt-46	NP_508112.1	UDPGT	19..527	CDD:278624	133/528 (25%)
ugt-46	NP_508112.1	egt	<213..503	CDD:223071	74/298 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I2192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I2693
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860