DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-6

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001369960.1	Gene:	ugt-6 / 179755	WormBaseID:	WBGene00013904	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	135/564 - (23%)
Similarity:	236/564 - (41%)	Gaps:	91/564 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVT--HKDIHL 69
            :||.:..:..:......|.:...:..||:.....:|..|.:||::||   ..:|.|.  :.|..|
Worm     6 LFLFISTLFGNAYSYKFLVISPVYGFSHMKYMAELANHLARAGNDVT---YFQPFVVDEYHDHTL 67

  Fly    70 IVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSD----PRFQRI---- 126
            |    ||:..:|......|:..|.......|.....|.....:|.|.:|..    |.|:.:
Worm    68 I----KEKSIKIWNYYHDELGRQHIPSQGCMRDAWHSSWYQSDAGAAILLSKYLFPAFEHMCRKM 128

  Fly   127 -------YETK---FDLMILGYFINDF-QLGVAHKLKVPVII-----NWMSAPVPAIDKYTGNPS 175
                   |:.|   ||:::...|  || .|.:|..|::|.||     |.::|..|.:    |.||
Worm   129 FEDTELHYDLKSRQFDVVLSEAF--DFCGLYLASYLEMPSIISTFTGNRLNALAPVL----GEPS 187

  Fly   176 ELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELR-KN 239
            .|.|:|    ..|...|.        :|.:|:        :|..:::.::.......|.|:: :.
Worm   188 FLHYLP----APTSQYGH--------ESTIFD--------RLNDVWHKIWSSYGFAQLFEMQYQQ 232

  Fly   240 ISMAFVGS-------------HLISEGP----IRPLVPALIEIGGIQVKD---KPDPLPKDIDQF 284
            :|....|.             |..:..|    :.|.:|.::.||||.|..   ..:....::.:.
Worm   233 VSKLTNGKVKHWKDIIHDVTYHFSNSNPYLDFVIPTIPKVVPIGGITVDHDYWSTNGNHSELLEH 297

  Fly   285 ISNAKQGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKENV--IWKWE---DLENTPGNSSNILY 344
            :.||::..||:|.||.|:|..:..|..:.:.||.|: ..|:  :||:|   |.|......:|:..
Worm   298 VLNARKHNVFISFGSMVRSVDMPKEFKKSMMKVFSD-HPNITFLWKYELPNDQEFLRILPTNVHV 361

  Fly   345 KNWLPQDDILAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLL 409
            ..|..|..:|:.....||:||.|.|...|......|.:.:|:|.||||||.::|:.|.......|
Worm   362 AKWFSQSALLSDQRVNLFVTHGGLGSTMELARAAKPAIVIPLFADQPGNAKMIERHGSVEIFSKL 426

  Fly   410 SI-TEDSLRDALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVH 473
            .| ....|...::::|..:.|:|...:.:...|.:|:|....:|...|...|....|||...:..
Worm   427 DIPNSKKLSSLIQKMLNTKYYQQNANRLADTLRFQPITPTDLMVKHAENAARFGKMPNLVPHAKD 491

  Fly   474 MNFIQLNNLD-IYALIVTILVLFVLLTRLVAKIVWNKFGGKAKI 516
            |.|.:..|:| |:.:.:.:.:||.::..:.:|:   |...|.|:
Worm   492 MGFFEYYNIDIIFIVFLLVWLLFSVVAHVFSKL---KLSLKIKV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	122/512 (24%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	131/535 (24%)
ugt-6	NP_001369960.1	GT1_Gtf-like	20..456	CDD:340817	113/469 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810